Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study

Background: The prognosis of patients with cervical cancer is significantly worsened in case of lymph node involvement. The goal of this study was to determine whether pathologic features in conization specimens can predict the sentinel lymph node (SLN) status in early-stage cervical cancer. Methods...

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Autores principales:	Vincent Balaya, Benedetta Guani, Julie Mereaux, Laurent Magaud, Basile Pache, Hélène Bonsang-Kitzis, Charlotte Ngô, David Desseauve, Patrice Mathevet, Fabrice Lécuru, on behalf of the SENTICOL Group
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cervical cancer sentinel lymph node conization SENTICOL stromal invasion lymphovascular space invasion Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e55e382a13524ea297d3274102c4757e
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spelling	oai:doaj.org-article:e55e382a13524ea297d3274102c4757e2021-11-11T15:31:04ZCan Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study10.3390/cancers132154232072-6694https://doaj.org/article/e55e382a13524ea297d3274102c4757e2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5423https://doaj.org/toc/2072-6694Background: The prognosis of patients with cervical cancer is significantly worsened in case of lymph node involvement. The goal of this study was to determine whether pathologic features in conization specimens can predict the sentinel lymph node (SLN) status in early-stage cervical cancer. Methods: An ancillary analysis of two prospective multicentric database on SLN biopsy for cervical cancer (SENTICOL I and II) was carried out. Patients with IA to IB2 2018 FIGO stage, who underwent preoperative conization before SLN biopsy were included. Results: Between January 2005 and July 2012, 161 patients from 25 French centers fulfilled the inclusion criteria. Macrometastases, micrometastases and Isolated tumor cells (ITCs) were found in 4 (2.5%), 6 (3.7%) and 5 (3.1%) patients respectively. Compared to negative SLN patients, patients with micrometastatic and macrometastatic SLN were more likely to have lymphovascular space invasion (LVSI) (60% vs. 29.5%, <i>p</i> = 0.04) and deep stromal invasion (DSI) ≥ 10 mm (50% vs. 17.8%, <i>p</i> = 0.04). Among the 93 patients with DSI < 10 mm and absence of LVSI on conization specimens, three patients (3.2%) had ITCs and only one (1.1%) had micrometastases. Conclusions: Patients with DSI < 10 mm and no LVSI in conization specimens had lower risk of micro- and macrometastatic SLN. In this subpopulation, full node dissection may be questionable in case of SLN unilateral detection.Vincent BalayaBenedetta GuaniJulie MereauxLaurent MagaudBasile PacheHélène Bonsang-KitzisCharlotte NgôDavid DesseauvePatrice MathevetFabrice Lécuruon behalf of the SENTICOL GroupMDPI AGarticlecervical cancersentinel lymph nodeconizationSENTICOLstromal invasionlymphovascular space invasionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5423, p 5423 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cervical cancer sentinel lymph node conization SENTICOL stromal invasion lymphovascular space invasion Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cervical cancer sentinel lymph node conization SENTICOL stromal invasion lymphovascular space invasion Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Vincent Balaya Benedetta Guani Julie Mereaux Laurent Magaud Basile Pache Hélène Bonsang-Kitzis Charlotte Ngô David Desseauve Patrice Mathevet Fabrice Lécuru on behalf of the SENTICOL Group Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study
description	Background: The prognosis of patients with cervical cancer is significantly worsened in case of lymph node involvement. The goal of this study was to determine whether pathologic features in conization specimens can predict the sentinel lymph node (SLN) status in early-stage cervical cancer. Methods: An ancillary analysis of two prospective multicentric database on SLN biopsy for cervical cancer (SENTICOL I and II) was carried out. Patients with IA to IB2 2018 FIGO stage, who underwent preoperative conization before SLN biopsy were included. Results: Between January 2005 and July 2012, 161 patients from 25 French centers fulfilled the inclusion criteria. Macrometastases, micrometastases and Isolated tumor cells (ITCs) were found in 4 (2.5%), 6 (3.7%) and 5 (3.1%) patients respectively. Compared to negative SLN patients, patients with micrometastatic and macrometastatic SLN were more likely to have lymphovascular space invasion (LVSI) (60% vs. 29.5%, <i>p</i> = 0.04) and deep stromal invasion (DSI) ≥ 10 mm (50% vs. 17.8%, <i>p</i> = 0.04). Among the 93 patients with DSI < 10 mm and absence of LVSI on conization specimens, three patients (3.2%) had ITCs and only one (1.1%) had micrometastases. Conclusions: Patients with DSI < 10 mm and no LVSI in conization specimens had lower risk of micro- and macrometastatic SLN. In this subpopulation, full node dissection may be questionable in case of SLN unilateral detection.
format	article
author	Vincent Balaya Benedetta Guani Julie Mereaux Laurent Magaud Basile Pache Hélène Bonsang-Kitzis Charlotte Ngô David Desseauve Patrice Mathevet Fabrice Lécuru on behalf of the SENTICOL Group
author_facet	Vincent Balaya Benedetta Guani Julie Mereaux Laurent Magaud Basile Pache Hélène Bonsang-Kitzis Charlotte Ngô David Desseauve Patrice Mathevet Fabrice Lécuru on behalf of the SENTICOL Group
author_sort	Vincent Balaya
title	Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study
title_short	Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study
title_full	Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study
title_fullStr	Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study
title_full_unstemmed	Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study
title_sort	can conization specimens predict sentinel lymph node status in early-stage cervical cancer? a senticol group study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e55e382a13524ea297d3274102c4757e
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Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study

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