Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy

Junhui Shi,1 Zhengyan Zhao,2 Zongjun Liu,3 Ruozheng Wu,1 You Wang11School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, People’s Republic of China; 2State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, People&rsq...

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Autores principales:	Shi J, Zhao Z, Liu Z, Wu R, Wang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	drug release ultralow intensity density functional theory near infrared light upconversion nanoparticles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e55e482b541b43008f0b3659d28b069f
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spelling	oai:doaj.org-article:e55e482b541b43008f0b3659d28b069f2021-12-02T08:15:52ZUltralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy1178-2013https://doaj.org/article/e55e482b541b43008f0b3659d28b069f2019-05-01T00:00:00Zhttps://www.dovepress.com/ultralow-intensity-nir-light-triggered-on-demand-drug-release-by-emplo-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Junhui Shi,1 Zhengyan Zhao,2 Zongjun Liu,3 Ruozheng Wu,1 You Wang11School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, People’s Republic of China; 2State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, People’s Republic of China; 3School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, People’s Republic of ChinaBackground: The design of novel nanoparticles with higher therapeutic efficacy and lower side effects, is still difficult but encouraging in cancer therapy. Specifically, for upconversion nanoparticles (UCNP)-based drug release, a high intensity of NIR light (1.4&sim;5.0 W/cm2,) above the maximum permissible exposure (0.33 W/cm2, for 980 nm) is commonly used and severely limits its practical application.Methods: The highly emissive UCNP is first synthesized and then coated with mesoporous silica (MS) shell (UCMS). Next, the surface of UCMS is modified with the thioether (-S-BP) linker, leading to UCMS-S-BP nanoparticles. Finally, after the drug doxorubicin (Dox) is loaded into the pore channels of UCMS, the pore openings are blocked by the β-cyclodextrin (β-CD) gatekeeper through the association with the -S-BP linker (UCMS(Dox)-S-BP@β-CD).Results: Upon 980 nm NIR light irradiation with an ultralow intensity of 0.30 W/cm,2 it is found that the loaded Dox can be released through the cleavage of thioether linkers triggering dissociation of β-CD gatekeepers. The in vitro results exhibited significantly therapeutic efficacy with 85.2% of HeLa cells killed in this study.Conclusions: An ultralow-intensity NIR light triggered on-demand drug release system has been developed by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy to avoid the potential photodamage on healthy neighbor cells.Keywords: drug release, ultralow intensity, density functional theory, near infrared light, upconversion nanoparticlesShi JZhao ZLiu ZWu RWang YDove Medical Pressarticledrug releaseultralow intensitydensity functional theorynear infrared lightupconversion nanoparticlesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 4017-4028 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug release ultralow intensity density functional theory near infrared light upconversion nanoparticles Medicine (General) R5-920
spellingShingle	drug release ultralow intensity density functional theory near infrared light upconversion nanoparticles Medicine (General) R5-920 Shi J Zhao Z Liu Z Wu R Wang Y Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy
description	Junhui Shi,1 Zhengyan Zhao,2 Zongjun Liu,3 Ruozheng Wu,1 You Wang11School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, People’s Republic of China; 2State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, People’s Republic of China; 3School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, People’s Republic of ChinaBackground: The design of novel nanoparticles with higher therapeutic efficacy and lower side effects, is still difficult but encouraging in cancer therapy. Specifically, for upconversion nanoparticles (UCNP)-based drug release, a high intensity of NIR light (1.4&sim;5.0 W/cm2,) above the maximum permissible exposure (0.33 W/cm2, for 980 nm) is commonly used and severely limits its practical application.Methods: The highly emissive UCNP is first synthesized and then coated with mesoporous silica (MS) shell (UCMS). Next, the surface of UCMS is modified with the thioether (-S-BP) linker, leading to UCMS-S-BP nanoparticles. Finally, after the drug doxorubicin (Dox) is loaded into the pore channels of UCMS, the pore openings are blocked by the β-cyclodextrin (β-CD) gatekeeper through the association with the -S-BP linker (UCMS(Dox)-S-BP@β-CD).Results: Upon 980 nm NIR light irradiation with an ultralow intensity of 0.30 W/cm,2 it is found that the loaded Dox can be released through the cleavage of thioether linkers triggering dissociation of β-CD gatekeepers. The in vitro results exhibited significantly therapeutic efficacy with 85.2% of HeLa cells killed in this study.Conclusions: An ultralow-intensity NIR light triggered on-demand drug release system has been developed by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy to avoid the potential photodamage on healthy neighbor cells.Keywords: drug release, ultralow intensity, density functional theory, near infrared light, upconversion nanoparticles
format	article
author	Shi J Zhao Z Liu Z Wu R Wang Y
author_facet	Shi J Zhao Z Liu Z Wu R Wang Y
author_sort	Shi J
title	Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy
title_short	Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy
title_full	Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy
title_fullStr	Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy
title_full_unstemmed	Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy
title_sort	ultralow-intensity nir light triggered on-demand drug release by employing highly emissive ucnp and photocleavable linker with low bond dissociation energy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/e55e482b541b43008f0b3659d28b069f
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Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy

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