Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery

Abstract The purpose of this study is to compare the effect of the different physical factors on low-density lipoproteins (LDL) accumulation from flowing blood to the arterial wall of the left coronary arteries. The three-dimensional (3D) computational model of the left coronary arterial tree is rec...

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Autores principales:	Xueping Chen, Jian Zhuang, Huanlei Huang, Yueheng Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e56048e5764146c1b247409608223bb8
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spelling	oai:doaj.org-article:e56048e5764146c1b247409608223bb82021-12-02T15:54:05ZFluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery10.1038/s41598-021-84155-32045-2322https://doaj.org/article/e56048e5764146c1b247409608223bb82021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84155-3https://doaj.org/toc/2045-2322Abstract The purpose of this study is to compare the effect of the different physical factors on low-density lipoproteins (LDL) accumulation from flowing blood to the arterial wall of the left coronary arteries. The three-dimensional (3D) computational model of the left coronary arterial tree is reconstructed from a patient-specific computed tomography angiography (CTA) image. The endothelium of the coronary artery is represented by a shear stress dependent three-pore model. Fluid–structure interaction ( $$FSI$$ FSI ) based numerical method is used to study the LDL transport from vascular lumen into the arterial wall. The results show that the high elastic property of the arterial wall decreases the complexity of the local flow field in the coronary bifurcation system. The places of high levels of LDL uptake coincide with the regions of low wall shear stress. In addition, hypertension promotes LDL uptake from flowing blood in the arterial wall, while the thickened arterial wall decreases this process. The present computer strategy combining the methods of coronary CTA image 3D reconstruction, $$FSI$$ FSI simulation, and three-pore modeling was illustrated to be effective on the simulation of the distribution and the uptake of LDL. This may have great potential for the early prediction of the local atherosclerosis lesion in the human left coronary artery.Xueping ChenJian ZhuangHuanlei HuangYueheng WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xueping Chen Jian Zhuang Huanlei Huang Yueheng Wu Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery
description	Abstract The purpose of this study is to compare the effect of the different physical factors on low-density lipoproteins (LDL) accumulation from flowing blood to the arterial wall of the left coronary arteries. The three-dimensional (3D) computational model of the left coronary arterial tree is reconstructed from a patient-specific computed tomography angiography (CTA) image. The endothelium of the coronary artery is represented by a shear stress dependent three-pore model. Fluid–structure interaction ( $$FSI$$ FSI ) based numerical method is used to study the LDL transport from vascular lumen into the arterial wall. The results show that the high elastic property of the arterial wall decreases the complexity of the local flow field in the coronary bifurcation system. The places of high levels of LDL uptake coincide with the regions of low wall shear stress. In addition, hypertension promotes LDL uptake from flowing blood in the arterial wall, while the thickened arterial wall decreases this process. The present computer strategy combining the methods of coronary CTA image 3D reconstruction, $$FSI$$ FSI simulation, and three-pore modeling was illustrated to be effective on the simulation of the distribution and the uptake of LDL. This may have great potential for the early prediction of the local atherosclerosis lesion in the human left coronary artery.
format	article
author	Xueping Chen Jian Zhuang Huanlei Huang Yueheng Wu
author_facet	Xueping Chen Jian Zhuang Huanlei Huang Yueheng Wu
author_sort	Xueping Chen
title	Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery
title_short	Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery
title_full	Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery
title_fullStr	Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery
title_full_unstemmed	Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery
title_sort	fluid–structure interactions (fsi) based study of low-density lipoproteins (ldl) uptake in the left coronary artery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e56048e5764146c1b247409608223bb8
work_keys_str_mv	AT xuepingchen fluidstructureinteractionsfsibasedstudyoflowdensitylipoproteinsldluptakeintheleftcoronaryartery AT jianzhuang fluidstructureinteractionsfsibasedstudyoflowdensitylipoproteinsldluptakeintheleftcoronaryartery AT huanleihuang fluidstructureinteractionsfsibasedstudyoflowdensitylipoproteinsldluptakeintheleftcoronaryartery AT yuehengwu fluidstructureinteractionsfsibasedstudyoflowdensitylipoproteinsldluptakeintheleftcoronaryartery
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Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery

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