Proton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland

Samir Aziz1, Alex Taylor1, Andrzej McConnachie3, Alex Kacperek2, Ewan Kemp11Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, Scotland, UK; 2Clatterbridge Centre for Oncology, Wirral, England, UK; 3Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland, U...

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Autores principales:	Samir Aziz, Alex Taylor, Andrzej McConnachie, Alex Kacperek, Ewan Kemp
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e562480b1c0b4c09b74a6a0743e1fa73
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spelling	oai:doaj.org-article:e562480b1c0b4c09b74a6a0743e1fa732021-12-02T00:48:00ZProton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland1177-54671177-5483https://doaj.org/article/e562480b1c0b4c09b74a6a0743e1fa732008-08-01T00:00:00Zhttp://www.dovepress.com/proton-beam-radiotherapy-in-the-management-of-uveal-melanoma-clinical--a2028https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Samir Aziz1, Alex Taylor1, Andrzej McConnachie3, Alex Kacperek2, Ewan Kemp11Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, Scotland, UK; 2Clatterbridge Centre for Oncology, Wirral, England, UK; 3Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland, UKAim: To evaluate proton-beam radiotherapy (PBRT) in the management of uveal melanoma in Scotland.Methods: A retrospective review was undertaken on all patients receiving PBRT for uveal melanoma (1994&ndash;2005). Data obtained included: gender, past ocular/medical history, age, presenting complaint(s), diagnosis, laterality, tumor location/ultrasound characteristics, visual acuity (VA) and intraocular pressure. At post-treatment reviews (3, 6, 12, and 24 months), the following data was obtained: VA, intraocular pressure, tumor appearance and ultrasound characteristics. Mean follow up was 38.8 months.Results: Seventy-six patients were included. Mean age was 64 years; male to female ratio was 1.1:1. Ninety-seven percent demonstrated initial treatment response; 87% had successful control of tumor growth. Mean pre-treatment tumor height was 6.2 mm v.s. 4.8 mm post-irradiation (p &lt;&nbsp;0.001). Pre-irradiation VA was &lt;3/60 in 18.5% compared with 74% post-irradiation (p &lt;&nbsp;0.0001). There was a statistically significant association between adverse events (enucleation, metastasis) and greater maximal basal tumor diameter. Eighteen eyes were enucleated. The median survival time was estimated to be 54 months.Conclusion: In our experience, PBRT is a precise, reliable and effective treatment in the management of large, and previously treated uveal melanomas. It prevents enucleation in the majority at short term follow-up.Keywords: proton-beam radiotherapy, uveal melanoma, visual acuity, enucleation, tumor Samir AzizAlex TaylorAndrzej McConnachieAlex KacperekEwan KempDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2009, Iss default, Pp 49-55 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Samir Aziz Alex Taylor Andrzej McConnachie Alex Kacperek Ewan Kemp Proton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland
description	Samir Aziz1, Alex Taylor1, Andrzej McConnachie3, Alex Kacperek2, Ewan Kemp11Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, Scotland, UK; 2Clatterbridge Centre for Oncology, Wirral, England, UK; 3Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland, UKAim: To evaluate proton-beam radiotherapy (PBRT) in the management of uveal melanoma in Scotland.Methods: A retrospective review was undertaken on all patients receiving PBRT for uveal melanoma (1994&ndash;2005). Data obtained included: gender, past ocular/medical history, age, presenting complaint(s), diagnosis, laterality, tumor location/ultrasound characteristics, visual acuity (VA) and intraocular pressure. At post-treatment reviews (3, 6, 12, and 24 months), the following data was obtained: VA, intraocular pressure, tumor appearance and ultrasound characteristics. Mean follow up was 38.8 months.Results: Seventy-six patients were included. Mean age was 64 years; male to female ratio was 1.1:1. Ninety-seven percent demonstrated initial treatment response; 87% had successful control of tumor growth. Mean pre-treatment tumor height was 6.2 mm v.s. 4.8 mm post-irradiation (p &lt;&nbsp;0.001). Pre-irradiation VA was &lt;3/60 in 18.5% compared with 74% post-irradiation (p &lt;&nbsp;0.0001). There was a statistically significant association between adverse events (enucleation, metastasis) and greater maximal basal tumor diameter. Eighteen eyes were enucleated. The median survival time was estimated to be 54 months.Conclusion: In our experience, PBRT is a precise, reliable and effective treatment in the management of large, and previously treated uveal melanomas. It prevents enucleation in the majority at short term follow-up.Keywords: proton-beam radiotherapy, uveal melanoma, visual acuity, enucleation, tumor
format	article
author	Samir Aziz Alex Taylor Andrzej McConnachie Alex Kacperek Ewan Kemp
author_facet	Samir Aziz Alex Taylor Andrzej McConnachie Alex Kacperek Ewan Kemp
author_sort	Samir Aziz
title	Proton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland
title_short	Proton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland
title_full	Proton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland
title_fullStr	Proton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland
title_full_unstemmed	Proton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland
title_sort	proton beam radiotherapy in the management of uveal melanoma: clinical experience in scotland
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/e562480b1c0b4c09b74a6a0743e1fa73
work_keys_str_mv	AT samiraziz protonbeamradiotherapyinthemanagementofuvealmelanomaclinicalexperienceinscotland AT alextaylor protonbeamradiotherapyinthemanagementofuvealmelanomaclinicalexperienceinscotland AT andrzejmcconnachie protonbeamradiotherapyinthemanagementofuvealmelanomaclinicalexperienceinscotland AT alexkacperek protonbeamradiotherapyinthemanagementofuvealmelanomaclinicalexperienceinscotland AT ewankemp protonbeamradiotherapyinthemanagementofuvealmelanomaclinicalexperienceinscotland
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Proton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland

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