In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers

Nanoparticle delivery of siRNA has problems with penetration and off target accumulation. Here, the authors report on the development of Y-shaped block catiomers which dynamically wrap around siRNA; demonstrate increased circulation times and delivery into hard to reach brain and pancreas tumour mod...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sumiyo Watanabe, Kotaro Hayashi, Kazuko Toh, Hyun Jin Kim, Xueying Liu, Hiroyuki Chaya, Shigeto Fukushima, Keisuke Katsushima, Yutaka Kondo, Satoshi Uchida, Satomi Ogura, Takahiro Nomoto, Hiroyasu Takemoto, Horacio Cabral, Hiroaki Kinoh, Hiroyoshi Y. Tanaka, Mitsunobu R. Kano, Yu Matsumoto, Hiroshi Fukuhara, Shunya Uchida, Masaomi Nangaku, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e56544229bd24572b3344d7cb418ce63
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e56544229bd24572b3344d7cb418ce63
record_format	dspace
spelling	oai:doaj.org-article:e56544229bd24572b3344d7cb418ce632021-12-02T17:01:58ZIn vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers10.1038/s41467-019-09856-w2041-1723https://doaj.org/article/e56544229bd24572b3344d7cb418ce632019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09856-whttps://doaj.org/toc/2041-1723Nanoparticle delivery of siRNA has problems with penetration and off target accumulation. Here, the authors report on the development of Y-shaped block catiomers which dynamically wrap around siRNA; demonstrate increased circulation times and delivery into hard to reach brain and pancreas tumour models.Sumiyo WatanabeKotaro HayashiKazuko TohHyun Jin KimXueying LiuHiroyuki ChayaShigeto FukushimaKeisuke KatsushimaYutaka KondoSatoshi UchidaSatomi OguraTakahiro NomotoHiroyasu TakemotoHoracio CabralHiroaki KinohHiroyoshi Y. TanakaMitsunobu R. KanoYu MatsumotoHiroshi FukuharaShunya UchidaMasaomi NangakuKensuke OsadaNobuhiro NishiyamaKanjiro MiyataKazunori KataokaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sumiyo Watanabe Kotaro Hayashi Kazuko Toh Hyun Jin Kim Xueying Liu Hiroyuki Chaya Shigeto Fukushima Keisuke Katsushima Yutaka Kondo Satoshi Uchida Satomi Ogura Takahiro Nomoto Hiroyasu Takemoto Horacio Cabral Hiroaki Kinoh Hiroyoshi Y. Tanaka Mitsunobu R. Kano Yu Matsumoto Hiroshi Fukuhara Shunya Uchida Masaomi Nangaku Kensuke Osada Nobuhiro Nishiyama Kanjiro Miyata Kazunori Kataoka In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
description	Nanoparticle delivery of siRNA has problems with penetration and off target accumulation. Here, the authors report on the development of Y-shaped block catiomers which dynamically wrap around siRNA; demonstrate increased circulation times and delivery into hard to reach brain and pancreas tumour models.
format	article
author	Sumiyo Watanabe Kotaro Hayashi Kazuko Toh Hyun Jin Kim Xueying Liu Hiroyuki Chaya Shigeto Fukushima Keisuke Katsushima Yutaka Kondo Satoshi Uchida Satomi Ogura Takahiro Nomoto Hiroyasu Takemoto Horacio Cabral Hiroaki Kinoh Hiroyoshi Y. Tanaka Mitsunobu R. Kano Yu Matsumoto Hiroshi Fukuhara Shunya Uchida Masaomi Nangaku Kensuke Osada Nobuhiro Nishiyama Kanjiro Miyata Kazunori Kataoka
author_facet	Sumiyo Watanabe Kotaro Hayashi Kazuko Toh Hyun Jin Kim Xueying Liu Hiroyuki Chaya Shigeto Fukushima Keisuke Katsushima Yutaka Kondo Satoshi Uchida Satomi Ogura Takahiro Nomoto Hiroyasu Takemoto Horacio Cabral Hiroaki Kinoh Hiroyoshi Y. Tanaka Mitsunobu R. Kano Yu Matsumoto Hiroshi Fukuhara Shunya Uchida Masaomi Nangaku Kensuke Osada Nobuhiro Nishiyama Kanjiro Miyata Kazunori Kataoka
author_sort	Sumiyo Watanabe
title	In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
title_short	In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
title_full	In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
title_fullStr	In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
title_full_unstemmed	In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
title_sort	in vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e56544229bd24572b3344d7cb418ce63
work_keys_str_mv	AT sumiyowatanabe invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT kotarohayashi invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT kazukotoh invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT hyunjinkim invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT xueyingliu invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT hiroyukichaya invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT shigetofukushima invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT keisukekatsushima invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT yutakakondo invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT satoshiuchida invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT satomiogura invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT takahironomoto invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT hiroyasutakemoto invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT horaciocabral invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT hiroakikinoh invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT hiroyoshiytanaka invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT mitsunoburkano invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT yumatsumoto invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT hiroshifukuhara invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT shunyauchida invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT masaominangaku invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT kensukeosada invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT nobuhironishiyama invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT kanjiromiyata invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers AT kazunorikataoka invivorendezvousofsmallnucleicaciddrugswithchargematchedblockcatiomerstotargetcancers
_version_	1718382001631789056

In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers

Ejemplares similares