Cyclometalated Iridium(III) Complex–Cationic Peptide Hybrids Trigger Paraptosis in Cancer Cells via an Intracellular Ca<sup>2+</sup> Overload from the Endoplasmic Reticulum and a Decrease in Mitochondrial Membrane Potential

Cyclometalated Iridium(III) Complex–Cationic Peptide Hybrids Trigger Paraptosis in Cancer Cells via an Intracellular Ca<sup>2+</sup> Overload from the Endoplasmic Reticulum and a Decrease in Mitochondrial Membrane Potential

In our previous paper, we reported that amphiphilic Ir complex–peptide hybrids (IPHs) containing basic peptides such as KK(K)GG (K: lysine, G: glycine) (e.g., ASb-2) exhibited potent anticancer activity against Jurkat cells, with the dead cells showing a strong green emission. Our initial mechanisti...

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Autores principales: Chandrasekar Balachandran, Kenta Yokoi, Kana Naito, Jebiti Haribabu, Yuichi Tamura, Masakazu Umezawa, Koji Tsuchiya, Toshitada Yoshihara, Seiji Tobita, Shin Aoki
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
cyclometalated iridium complex
peptide hybrid
anticancer agents
paraptosis
cytoplasmic vacuolization
Ca<sup>2+</sup>
Organic chemistry
QD241-441
Acceso en línea:https://doaj.org/article/e56603c0095a4cdfba9e31644617f6d3
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