Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer

Qi Shen, Ying Wang, Yi ZhangSchool of Pharmacy, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, People&rsquo;s Republic of ChinaAbstract: The effect of eugenol on colchicine transport across an isolated rat intestinal membrane was studied using an in vitro diffusion chamb...

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Autores principales:	Shen Q, Wang Y, Zhang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e566ff6ad16f4a629d7246e2878ab75e
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spelling	oai:doaj.org-article:e566ff6ad16f4a629d7246e2878ab75e2021-12-02T02:10:29ZImprovement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer1176-91141178-2013https://doaj.org/article/e566ff6ad16f4a629d7246e2878ab75e2011-06-01T00:00:00Zhttp://www.dovepress.com/improvement-of-colchicine-oral-bioavailability-by-incorporating-eugeno-a7686https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Qi Shen, Ying Wang, Yi ZhangSchool of Pharmacy, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, People&rsquo;s Republic of ChinaAbstract: The effect of eugenol on colchicine transport across an isolated rat intestinal membrane was studied using an in vitro diffusion chamber system. We found that eugenol increased the absorptive transport of the drug efficiently. The effect of eugenol on intestinal absorption of colchicine in an oral administrative nanoemulsion formulation was also demonstrated in vivo. The colchicine nanoemulsion was prepared with isopropyl myristate, eugenol, Tween80, ethanol and water, and eugenol was used as an oil phase in the formulation; an average particle size of this nanoemulsion was 41.2 &plusmn; 7.2 nm. The permeation of colchicine in the nanoemulsion across the intestinal membrane was significantly different from that of the control group (0.2 mM colchicine). Finally, co-administration of eugenol in colchicine nanoemulsion to enhance the colchicine bioavailability was investigated by an oral administration method. After oral administration of colchicine (8 mg/kg) in the form of either the nanoemulsion or in free colchicine solution, the relative bioavailability of nanoemulsion and eugenol&ndash;nanoemulsion were enhanced by about 1.6- and 2.1-fold, respectively, compared with free colchicine solution. The procedure indicated that the intestinal absorption of colchicine was enhanced significantly by eugenol in the tested nanoemulsion. All the results suggested that eugenol is an efficient component in an oral administrative formulation for improving the intestinal absorption of colchicine.Keywords: intestinal absorption, nanoemulsion, absorption enhancement, eugenolShen QWang YZhang YDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1237-1243 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Shen Q Wang Y Zhang Y Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer
description	Qi Shen, Ying Wang, Yi ZhangSchool of Pharmacy, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, People&rsquo;s Republic of ChinaAbstract: The effect of eugenol on colchicine transport across an isolated rat intestinal membrane was studied using an in vitro diffusion chamber system. We found that eugenol increased the absorptive transport of the drug efficiently. The effect of eugenol on intestinal absorption of colchicine in an oral administrative nanoemulsion formulation was also demonstrated in vivo. The colchicine nanoemulsion was prepared with isopropyl myristate, eugenol, Tween80, ethanol and water, and eugenol was used as an oil phase in the formulation; an average particle size of this nanoemulsion was 41.2 &plusmn; 7.2 nm. The permeation of colchicine in the nanoemulsion across the intestinal membrane was significantly different from that of the control group (0.2 mM colchicine). Finally, co-administration of eugenol in colchicine nanoemulsion to enhance the colchicine bioavailability was investigated by an oral administration method. After oral administration of colchicine (8 mg/kg) in the form of either the nanoemulsion or in free colchicine solution, the relative bioavailability of nanoemulsion and eugenol&ndash;nanoemulsion were enhanced by about 1.6- and 2.1-fold, respectively, compared with free colchicine solution. The procedure indicated that the intestinal absorption of colchicine was enhanced significantly by eugenol in the tested nanoemulsion. All the results suggested that eugenol is an efficient component in an oral administrative formulation for improving the intestinal absorption of colchicine.Keywords: intestinal absorption, nanoemulsion, absorption enhancement, eugenol
format	article
author	Shen Q Wang Y Zhang Y
author_facet	Shen Q Wang Y Zhang Y
author_sort	Shen Q
title	Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer
title_short	Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer
title_full	Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer
title_fullStr	Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer
title_full_unstemmed	Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer
title_sort	improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/e566ff6ad16f4a629d7246e2878ab75e
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Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer

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