Glucose Metabolism in Acute Kidney Injury and Kidney Repair
The kidneys play an indispensable role in glucose homeostasis via glucose reabsorption, production, and utilization. Conversely, aberrant glucose metabolism is involved in the onset, progression, and prognosis of kidney diseases, including acute kidney injury (AKI). In this review, we describe the r...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:e567ae2e7c9e481d8e7720f2e64319742021-12-01T13:13:35ZGlucose Metabolism in Acute Kidney Injury and Kidney Repair2296-858X10.3389/fmed.2021.744122https://doaj.org/article/e567ae2e7c9e481d8e7720f2e64319742021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.744122/fullhttps://doaj.org/toc/2296-858XThe kidneys play an indispensable role in glucose homeostasis via glucose reabsorption, production, and utilization. Conversely, aberrant glucose metabolism is involved in the onset, progression, and prognosis of kidney diseases, including acute kidney injury (AKI). In this review, we describe the regulation of glucose homeostasis and related molecular factors in kidneys under normal physiological conditions. Furthermore, we summarize recent investigations about the relationship between glucose metabolism and different types of AKI. We also analyze the involvement of glucose metabolism in kidney repair after injury, including renal fibrosis. Further research on glucose metabolism in kidney injury and repair may lead to the identification of novel therapeutic targets for the prevention and treatment of kidney diseases.Lu WenLu WenLu WenYing LiSiyao LiSiyao LiSiyao LiXiaoru HuXiaoru HuXiaoru HuQingqing WeiQingqing WeiZheng DongZheng DongZheng DongFrontiers Media S.A.articleglucose metabolismglycolysis (warburg effect)SGLTskidney injury and repairrenal fibrosisMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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DOAJ |
| language |
EN |
| topic |
glucose metabolism glycolysis (warburg effect) SGLTs kidney injury and repair renal fibrosis Medicine (General) R5-920 |
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glucose metabolism glycolysis (warburg effect) SGLTs kidney injury and repair renal fibrosis Medicine (General) R5-920 Lu Wen Lu Wen Lu Wen Ying Li Siyao Li Siyao Li Siyao Li Xiaoru Hu Xiaoru Hu Xiaoru Hu Qingqing Wei Qingqing Wei Zheng Dong Zheng Dong Zheng Dong Glucose Metabolism in Acute Kidney Injury and Kidney Repair |
| description |
The kidneys play an indispensable role in glucose homeostasis via glucose reabsorption, production, and utilization. Conversely, aberrant glucose metabolism is involved in the onset, progression, and prognosis of kidney diseases, including acute kidney injury (AKI). In this review, we describe the regulation of glucose homeostasis and related molecular factors in kidneys under normal physiological conditions. Furthermore, we summarize recent investigations about the relationship between glucose metabolism and different types of AKI. We also analyze the involvement of glucose metabolism in kidney repair after injury, including renal fibrosis. Further research on glucose metabolism in kidney injury and repair may lead to the identification of novel therapeutic targets for the prevention and treatment of kidney diseases. |
| format |
article |
| author |
Lu Wen Lu Wen Lu Wen Ying Li Siyao Li Siyao Li Siyao Li Xiaoru Hu Xiaoru Hu Xiaoru Hu Qingqing Wei Qingqing Wei Zheng Dong Zheng Dong Zheng Dong |
| author_facet |
Lu Wen Lu Wen Lu Wen Ying Li Siyao Li Siyao Li Siyao Li Xiaoru Hu Xiaoru Hu Xiaoru Hu Qingqing Wei Qingqing Wei Zheng Dong Zheng Dong Zheng Dong |
| author_sort |
Lu Wen |
| title |
Glucose Metabolism in Acute Kidney Injury and Kidney Repair |
| title_short |
Glucose Metabolism in Acute Kidney Injury and Kidney Repair |
| title_full |
Glucose Metabolism in Acute Kidney Injury and Kidney Repair |
| title_fullStr |
Glucose Metabolism in Acute Kidney Injury and Kidney Repair |
| title_full_unstemmed |
Glucose Metabolism in Acute Kidney Injury and Kidney Repair |
| title_sort |
glucose metabolism in acute kidney injury and kidney repair |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/e567ae2e7c9e481d8e7720f2e6431974 |
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