Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study.
<h4>Background</h4>Reported findings are inconsistent whether hypothalamic-pituitary-adrenal (HPA) signaling becomes hyperactive with increasing age, resulting in increasing levels of cortisol. Our previous research strongly suggests that offspring from long-lived families are biological...
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2012
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oai:doaj.org-article:e56897d82e5a489f8bbe46aca4256e8e2021-11-18T07:28:23ZFamilial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study.1932-620310.1371/journal.pone.0031166https://doaj.org/article/e56897d82e5a489f8bbe46aca4256e8e2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22348049/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Reported findings are inconsistent whether hypothalamic-pituitary-adrenal (HPA) signaling becomes hyperactive with increasing age, resulting in increasing levels of cortisol. Our previous research strongly suggests that offspring from long-lived families are biologically younger. In this study we assessed whether these offspring have a lower HPA axis activity, as measured by lower levels of cortisol and higher cortisol feedback sensitivity.<h4>Methods</h4>Salivary cortisol levels were measured at four time points within the first hour upon awakening and at two time points in the evening in a cohort comprising 149 offspring and 154 partners from the Leiden Longevity Study. A dexamethasone suppression test was performed as a measure of cortisol feedback sensitivity. Age, gender and body mass index, smoking and disease history (type 2 diabetes and hypertension) were considered as possible confounding factors.<h4>Results</h4>Salivary cortisol secretion was lower in offspring compared to partners in the morning (Area Under the Curve = 15.6 versus 17.1 nmol/L, respectively; p = 0.048) and in the evening (Area Under the Curve = 3.32 versus 3.82 nmol/L, respectively; p = 0.024). Salivary cortisol levels were not different after dexamethasone (0.5 mg) suppression between offspring and partners (4.82 versus 5.26 nmol/L, respectively; p = 0.28).<h4>Conclusion</h4>Offspring of nonagenarian siblings are marked by a lower HPA axis activity (reflected by lower diurnal salivary cortisol levels), but not by a difference in cortisol feedback sensitivity. Further in-depth studies aimed at characterizing the HPA axis in offspring and partners are needed.Raymond NoordamSteffy W M JansenAbimbola A AkintolaNicole Y L OeiAndrea B MaierHanno PijlP Eline SlagboomRudi G J WestendorpJeroen van der GrondAnton J M de CraenDiana van HeemstLeiden Longevity Study groupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31166 (2012) |
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Medicine R Science Q |
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Medicine R Science Q Raymond Noordam Steffy W M Jansen Abimbola A Akintola Nicole Y L Oei Andrea B Maier Hanno Pijl P Eline Slagboom Rudi G J Westendorp Jeroen van der Grond Anton J M de Craen Diana van Heemst Leiden Longevity Study group Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study. |
| description |
<h4>Background</h4>Reported findings are inconsistent whether hypothalamic-pituitary-adrenal (HPA) signaling becomes hyperactive with increasing age, resulting in increasing levels of cortisol. Our previous research strongly suggests that offspring from long-lived families are biologically younger. In this study we assessed whether these offspring have a lower HPA axis activity, as measured by lower levels of cortisol and higher cortisol feedback sensitivity.<h4>Methods</h4>Salivary cortisol levels were measured at four time points within the first hour upon awakening and at two time points in the evening in a cohort comprising 149 offspring and 154 partners from the Leiden Longevity Study. A dexamethasone suppression test was performed as a measure of cortisol feedback sensitivity. Age, gender and body mass index, smoking and disease history (type 2 diabetes and hypertension) were considered as possible confounding factors.<h4>Results</h4>Salivary cortisol secretion was lower in offspring compared to partners in the morning (Area Under the Curve = 15.6 versus 17.1 nmol/L, respectively; p = 0.048) and in the evening (Area Under the Curve = 3.32 versus 3.82 nmol/L, respectively; p = 0.024). Salivary cortisol levels were not different after dexamethasone (0.5 mg) suppression between offspring and partners (4.82 versus 5.26 nmol/L, respectively; p = 0.28).<h4>Conclusion</h4>Offspring of nonagenarian siblings are marked by a lower HPA axis activity (reflected by lower diurnal salivary cortisol levels), but not by a difference in cortisol feedback sensitivity. Further in-depth studies aimed at characterizing the HPA axis in offspring and partners are needed. |
| format |
article |
| author |
Raymond Noordam Steffy W M Jansen Abimbola A Akintola Nicole Y L Oei Andrea B Maier Hanno Pijl P Eline Slagboom Rudi G J Westendorp Jeroen van der Grond Anton J M de Craen Diana van Heemst Leiden Longevity Study group |
| author_facet |
Raymond Noordam Steffy W M Jansen Abimbola A Akintola Nicole Y L Oei Andrea B Maier Hanno Pijl P Eline Slagboom Rudi G J Westendorp Jeroen van der Grond Anton J M de Craen Diana van Heemst Leiden Longevity Study group |
| author_sort |
Raymond Noordam |
| title |
Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study. |
| title_short |
Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study. |
| title_full |
Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study. |
| title_fullStr |
Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study. |
| title_full_unstemmed |
Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study. |
| title_sort |
familial longevity is marked by lower diurnal salivary cortisol levels: the leiden longevity study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/e56897d82e5a489f8bbe46aca4256e8e |
| work_keys_str_mv |
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