Case Report: Markedly Long-Term Preservation of Pancreatic β‐Cell Function in a Subject With Elderly Onset of Type 1 Diabetes Mellitus Showing High-Titer Autoimmune Antibodies for Over 4 Years

Type 1 diabetes mellitus (T1DM) is mainly triggered by autoimmune β-cell destruction, usually leading to absolute insulin deficiency. Regarding the speed of β-cell destruction, there are large variations depending on age. In some adult cases, sufficient β-cell function is sometimes retained for a re...

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Autores principales:	Ryo Shigemoto, Takatoshi Anno, Fumiko Kawasaki, Kohei Kaku, Hideaki Kaneto
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	type 1 diabetes mellitus β-cell function autoimmune antibody anti-GAD antibody anti-IA-2 antibody elderly onset Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e56a87368582415391e3bd6c5d7313bf
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spelling	oai:doaj.org-article:e56a87368582415391e3bd6c5d7313bf2021-12-01T02:18:17ZCase Report: Markedly Long-Term Preservation of Pancreatic β‐Cell Function in a Subject With Elderly Onset of Type 1 Diabetes Mellitus Showing High-Titer Autoimmune Antibodies for Over 4 Years1664-322410.3389/fimmu.2021.752423https://doaj.org/article/e56a87368582415391e3bd6c5d7313bf2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.752423/fullhttps://doaj.org/toc/1664-3224Type 1 diabetes mellitus (T1DM) is mainly triggered by autoimmune β-cell destruction, usually leading to absolute insulin deficiency. Regarding the speed of β-cell destruction, there are large variations depending on age. In some adult cases, sufficient β-cell function is sometimes retained for a relatively long period and eventually they become dependent on insulin for survival. It is known that even in subjects with T1DM showing high titers of such antibodies, insulin secretory capacity is preserved under several conditions such as “honeymoon” period and slowly progressive T1DM (SPIDDM). Herein, we reported the acute onset T1DM subject with long-term preservation of β-cell function, although his anti-GAD antibody and anti-IA-2 antibody titers were very high for more than 4 years. This case is very important in that his β-cell function was preserved with dipeptidyl peptidase-4 inhibitor alone. This means that there are large variations in the speed of β-cell destruction in the onset of T1DM.Ryo ShigemotoTakatoshi AnnoFumiko KawasakiKohei KakuHideaki KanetoFrontiers Media S.A.articletype 1 diabetes mellitusβ-cell functionautoimmune antibodyanti-GAD antibodyanti-IA-2 antibodyelderly onsetImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 1 diabetes mellitus β-cell function autoimmune antibody anti-GAD antibody anti-IA-2 antibody elderly onset Immunologic diseases. Allergy RC581-607
spellingShingle	type 1 diabetes mellitus β-cell function autoimmune antibody anti-GAD antibody anti-IA-2 antibody elderly onset Immunologic diseases. Allergy RC581-607 Ryo Shigemoto Takatoshi Anno Fumiko Kawasaki Kohei Kaku Hideaki Kaneto Case Report: Markedly Long-Term Preservation of Pancreatic β‐Cell Function in a Subject With Elderly Onset of Type 1 Diabetes Mellitus Showing High-Titer Autoimmune Antibodies for Over 4 Years
description	Type 1 diabetes mellitus (T1DM) is mainly triggered by autoimmune β-cell destruction, usually leading to absolute insulin deficiency. Regarding the speed of β-cell destruction, there are large variations depending on age. In some adult cases, sufficient β-cell function is sometimes retained for a relatively long period and eventually they become dependent on insulin for survival. It is known that even in subjects with T1DM showing high titers of such antibodies, insulin secretory capacity is preserved under several conditions such as “honeymoon” period and slowly progressive T1DM (SPIDDM). Herein, we reported the acute onset T1DM subject with long-term preservation of β-cell function, although his anti-GAD antibody and anti-IA-2 antibody titers were very high for more than 4 years. This case is very important in that his β-cell function was preserved with dipeptidyl peptidase-4 inhibitor alone. This means that there are large variations in the speed of β-cell destruction in the onset of T1DM.
format	article
author	Ryo Shigemoto Takatoshi Anno Fumiko Kawasaki Kohei Kaku Hideaki Kaneto
author_facet	Ryo Shigemoto Takatoshi Anno Fumiko Kawasaki Kohei Kaku Hideaki Kaneto
author_sort	Ryo Shigemoto
title	Case Report: Markedly Long-Term Preservation of Pancreatic β‐Cell Function in a Subject With Elderly Onset of Type 1 Diabetes Mellitus Showing High-Titer Autoimmune Antibodies for Over 4 Years
title_short	Case Report: Markedly Long-Term Preservation of Pancreatic β‐Cell Function in a Subject With Elderly Onset of Type 1 Diabetes Mellitus Showing High-Titer Autoimmune Antibodies for Over 4 Years
title_full	Case Report: Markedly Long-Term Preservation of Pancreatic β‐Cell Function in a Subject With Elderly Onset of Type 1 Diabetes Mellitus Showing High-Titer Autoimmune Antibodies for Over 4 Years
title_fullStr	Case Report: Markedly Long-Term Preservation of Pancreatic β‐Cell Function in a Subject With Elderly Onset of Type 1 Diabetes Mellitus Showing High-Titer Autoimmune Antibodies for Over 4 Years
title_full_unstemmed	Case Report: Markedly Long-Term Preservation of Pancreatic β‐Cell Function in a Subject With Elderly Onset of Type 1 Diabetes Mellitus Showing High-Titer Autoimmune Antibodies for Over 4 Years
title_sort	case report: markedly long-term preservation of pancreatic β‐cell function in a subject with elderly onset of type 1 diabetes mellitus showing high-titer autoimmune antibodies for over 4 years
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e56a87368582415391e3bd6c5d7313bf
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Case Report: Markedly Long-Term Preservation of Pancreatic β‐Cell Function in a Subject With Elderly Onset of Type 1 Diabetes Mellitus Showing High-Titer Autoimmune Antibodies for Over 4 Years

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