A Systematic Review and Meta-Analysis of Transcranial Direct Current Stimulation to Remediate Age-Related Cognitive Decline in Healthy Older Adults
Aprinda Indahlastari,1,2 Cheshire Hardcastle,1,2 Alejandro Albizu,1,3 Stacey Alvarez-Alvarado,1,2 Emanuel M Boutzoukas,1,2 Nicole D Evangelista,1,2 Hanna K Hausman,1,2 Jessica Kraft,1,3 Kailey Langer,1,2 Adam J Woods1– 3 1Center for Cognitive Aging and Memory, McKnight Brain Institute, Uni...
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Dove Medical Press
2021
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oai:doaj.org-article:e56acc63a13c462597d1ecf52c13bb762021-12-02T15:59:21ZA Systematic Review and Meta-Analysis of Transcranial Direct Current Stimulation to Remediate Age-Related Cognitive Decline in Healthy Older Adults1178-2021https://doaj.org/article/e56acc63a13c462597d1ecf52c13bb762021-03-01T00:00:00Zhttps://www.dovepress.com/a-systematic-review-and-meta-analysis-of-transcranial-direct-current-s-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Aprinda Indahlastari,1,2 Cheshire Hardcastle,1,2 Alejandro Albizu,1,3 Stacey Alvarez-Alvarado,1,2 Emanuel M Boutzoukas,1,2 Nicole D Evangelista,1,2 Hanna K Hausman,1,2 Jessica Kraft,1,3 Kailey Langer,1,2 Adam J Woods1– 3 1Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; 2Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; 3Department of Neuroscience, University of Florida, Gainesville, FL, USACorrespondence: Aprinda IndahlastariDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USATel +1 352-294-5842Email aprinda.indahlas@phhp.ufl.eduBackground: Transcranial direct current stimulation (tDCS) has been proposed as a possible method for remediating age-associated cognitive decline in the older adult population. While tDCS has shown potential for improving cognitive functions in healthy older adults, stimulation outcomes on various cognitive domains have been mixed.Methods: A systematic search was performed in four databases: PubMed, EMBASE, Web of Science, and PsychInfo. Search results were then screened for eligibility based on inclusion/exclusion criteria to only include studies where tDCS was applied to improve cognition in healthy older adults 65 years and above. Eligible studies were reviewed and demographic characteristics, tDCS dose parameters, study procedures, and cognitive outcomes were extracted. Reported effect sizes for active compared to sham group in representative cognitive domain were converted to Hedges’ g.Main Results: A total of thirteen studies involving healthy older adults (n=532, mean age=71.2+ 5.3 years) were included in the meta-analysis. The majority of included studies (94%) targeted the prefrontal cortex with stimulation intensity 1– 2 mA using various electrode placements with anodes near the frontal region. Across all studies, we found Hedges’ g values ranged from − 0.31 to 1.85 as reported group effect sizes of active stimulation compared to sham.Conclusion: While observed outcomes varied, overall findings indicated promising effects of tDCS to remediate cognitive aging and thus deserves further exploration. Future characterization of inter-individual variability in tDCS dose response and applications in larger cohorts are warranted to further validate benefits of tDCS for cognition in healthy older adults.Keywords: tES, tDCS, aging, cognitive declineIndahlastari AHardcastle CAlbizu AAlvarez-Alvarado SBoutzoukas EMEvangelista NDHausman HKKraft JLanger KWoods AJDove Medical Pressarticletestdcsagingcognitive declineNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 971-990 (2021) |
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tes tdcs aging cognitive decline Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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tes tdcs aging cognitive decline Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Indahlastari A Hardcastle C Albizu A Alvarez-Alvarado S Boutzoukas EM Evangelista ND Hausman HK Kraft J Langer K Woods AJ A Systematic Review and Meta-Analysis of Transcranial Direct Current Stimulation to Remediate Age-Related Cognitive Decline in Healthy Older Adults |
| description |
Aprinda Indahlastari,1,2 Cheshire Hardcastle,1,2 Alejandro Albizu,1,3 Stacey Alvarez-Alvarado,1,2 Emanuel M Boutzoukas,1,2 Nicole D Evangelista,1,2 Hanna K Hausman,1,2 Jessica Kraft,1,3 Kailey Langer,1,2 Adam J Woods1– 3 1Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; 2Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; 3Department of Neuroscience, University of Florida, Gainesville, FL, USACorrespondence: Aprinda IndahlastariDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USATel +1 352-294-5842Email aprinda.indahlas@phhp.ufl.eduBackground: Transcranial direct current stimulation (tDCS) has been proposed as a possible method for remediating age-associated cognitive decline in the older adult population. While tDCS has shown potential for improving cognitive functions in healthy older adults, stimulation outcomes on various cognitive domains have been mixed.Methods: A systematic search was performed in four databases: PubMed, EMBASE, Web of Science, and PsychInfo. Search results were then screened for eligibility based on inclusion/exclusion criteria to only include studies where tDCS was applied to improve cognition in healthy older adults 65 years and above. Eligible studies were reviewed and demographic characteristics, tDCS dose parameters, study procedures, and cognitive outcomes were extracted. Reported effect sizes for active compared to sham group in representative cognitive domain were converted to Hedges’ g.Main Results: A total of thirteen studies involving healthy older adults (n=532, mean age=71.2+ 5.3 years) were included in the meta-analysis. The majority of included studies (94%) targeted the prefrontal cortex with stimulation intensity 1– 2 mA using various electrode placements with anodes near the frontal region. Across all studies, we found Hedges’ g values ranged from − 0.31 to 1.85 as reported group effect sizes of active stimulation compared to sham.Conclusion: While observed outcomes varied, overall findings indicated promising effects of tDCS to remediate cognitive aging and thus deserves further exploration. Future characterization of inter-individual variability in tDCS dose response and applications in larger cohorts are warranted to further validate benefits of tDCS for cognition in healthy older adults.Keywords: tES, tDCS, aging, cognitive decline |
| format |
article |
| author |
Indahlastari A Hardcastle C Albizu A Alvarez-Alvarado S Boutzoukas EM Evangelista ND Hausman HK Kraft J Langer K Woods AJ |
| author_facet |
Indahlastari A Hardcastle C Albizu A Alvarez-Alvarado S Boutzoukas EM Evangelista ND Hausman HK Kraft J Langer K Woods AJ |
| author_sort |
Indahlastari A |
| title |
A Systematic Review and Meta-Analysis of Transcranial Direct Current Stimulation to Remediate Age-Related Cognitive Decline in Healthy Older Adults |
| title_short |
A Systematic Review and Meta-Analysis of Transcranial Direct Current Stimulation to Remediate Age-Related Cognitive Decline in Healthy Older Adults |
| title_full |
A Systematic Review and Meta-Analysis of Transcranial Direct Current Stimulation to Remediate Age-Related Cognitive Decline in Healthy Older Adults |
| title_fullStr |
A Systematic Review and Meta-Analysis of Transcranial Direct Current Stimulation to Remediate Age-Related Cognitive Decline in Healthy Older Adults |
| title_full_unstemmed |
A Systematic Review and Meta-Analysis of Transcranial Direct Current Stimulation to Remediate Age-Related Cognitive Decline in Healthy Older Adults |
| title_sort |
systematic review and meta-analysis of transcranial direct current stimulation to remediate age-related cognitive decline in healthy older adults |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/e56acc63a13c462597d1ecf52c13bb76 |
| work_keys_str_mv |
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