Sensorimotor stroke alters hippocampo-thalamic network activity

Abstract Many stroke survivors experience persisting episodic memory disturbances. Since hippocampal and para-hippocampal areas are usually spared from the infarcted area, alterations of memory processing networks remote from the ischemic brain region might be responsible for the observed clinical s...

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Autores principales:	Philipp Baumgartner, Mohamad El Amki, Oliver Bracko, Andreas R. Luft, Susanne Wegener
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Sensorimotor Stroke Middle Cerebral Artery Occlusion (MCAO) Lateral Septal Nucleus Post-stroke Cognitive Impairment Entorhinal Cortex (EC) Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e56c1c86ab1b464aba0467c7bfa15ad7
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spelling	oai:doaj.org-article:e56c1c86ab1b464aba0467c7bfa15ad72021-12-02T15:08:25ZSensorimotor stroke alters hippocampo-thalamic network activity10.1038/s41598-018-34002-92045-2322https://doaj.org/article/e56c1c86ab1b464aba0467c7bfa15ad72018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-34002-9https://doaj.org/toc/2045-2322Abstract Many stroke survivors experience persisting episodic memory disturbances. Since hippocampal and para-hippocampal areas are usually spared from the infarcted area, alterations of memory processing networks remote from the ischemic brain region might be responsible for the observed clinical symptoms. To pinpoint changes in activity of hippocampal connections and their role in post-stroke cognitive impairment, we induced ischemic stroke by occlusion of the middle cerebral artery (MCAO) in adult rats and analyzed the functional and structural consequences using activity-dependent manganese (Mn2+) enhanced MRI (MEMRI) along with behavioral and histopathological analysis. MCAO caused stroke lesions of variable extent along with sensorimotor and cognitive deficits. Direct hippocampal injury occurred in some rats, but was no prerequisite for cognitive impairment. In healthy rats, injection of Mn2+ into the entorhinal cortex resulted in distribution of the tracer within the hippocampal subfields into the lateral septal nuclei. In MCAO rats, Mn2+ accumulated in the ipsilateral thalamus. Histopathological analysis revealed secondary thalamic degeneration 28 days after stroke. Our findings provide in vivo evidence that remote sensorimotor stroke modifies the activity of hippocampal-thalamic networks. In addition to potentially reversible alterations in signaling of these connections, structural damage of the thalamus likely reinforces dysfunction of hippocampal-thalamic circuitries.Philipp BaumgartnerMohamad El AmkiOliver BrackoAndreas R. LuftSusanne WegenerNature PortfolioarticleSensorimotor StrokeMiddle Cerebral Artery Occlusion (MCAO)Lateral Septal NucleusPost-stroke Cognitive ImpairmentEntorhinal Cortex (EC)MedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sensorimotor Stroke Middle Cerebral Artery Occlusion (MCAO) Lateral Septal Nucleus Post-stroke Cognitive Impairment Entorhinal Cortex (EC) Medicine R Science Q
spellingShingle	Sensorimotor Stroke Middle Cerebral Artery Occlusion (MCAO) Lateral Septal Nucleus Post-stroke Cognitive Impairment Entorhinal Cortex (EC) Medicine R Science Q Philipp Baumgartner Mohamad El Amki Oliver Bracko Andreas R. Luft Susanne Wegener Sensorimotor stroke alters hippocampo-thalamic network activity
description	Abstract Many stroke survivors experience persisting episodic memory disturbances. Since hippocampal and para-hippocampal areas are usually spared from the infarcted area, alterations of memory processing networks remote from the ischemic brain region might be responsible for the observed clinical symptoms. To pinpoint changes in activity of hippocampal connections and their role in post-stroke cognitive impairment, we induced ischemic stroke by occlusion of the middle cerebral artery (MCAO) in adult rats and analyzed the functional and structural consequences using activity-dependent manganese (Mn2+) enhanced MRI (MEMRI) along with behavioral and histopathological analysis. MCAO caused stroke lesions of variable extent along with sensorimotor and cognitive deficits. Direct hippocampal injury occurred in some rats, but was no prerequisite for cognitive impairment. In healthy rats, injection of Mn2+ into the entorhinal cortex resulted in distribution of the tracer within the hippocampal subfields into the lateral septal nuclei. In MCAO rats, Mn2+ accumulated in the ipsilateral thalamus. Histopathological analysis revealed secondary thalamic degeneration 28 days after stroke. Our findings provide in vivo evidence that remote sensorimotor stroke modifies the activity of hippocampal-thalamic networks. In addition to potentially reversible alterations in signaling of these connections, structural damage of the thalamus likely reinforces dysfunction of hippocampal-thalamic circuitries.
format	article
author	Philipp Baumgartner Mohamad El Amki Oliver Bracko Andreas R. Luft Susanne Wegener
author_facet	Philipp Baumgartner Mohamad El Amki Oliver Bracko Andreas R. Luft Susanne Wegener
author_sort	Philipp Baumgartner
title	Sensorimotor stroke alters hippocampo-thalamic network activity
title_short	Sensorimotor stroke alters hippocampo-thalamic network activity
title_full	Sensorimotor stroke alters hippocampo-thalamic network activity
title_fullStr	Sensorimotor stroke alters hippocampo-thalamic network activity
title_full_unstemmed	Sensorimotor stroke alters hippocampo-thalamic network activity
title_sort	sensorimotor stroke alters hippocampo-thalamic network activity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e56c1c86ab1b464aba0467c7bfa15ad7
work_keys_str_mv	AT philippbaumgartner sensorimotorstrokealtershippocampothalamicnetworkactivity AT mohamadelamki sensorimotorstrokealtershippocampothalamicnetworkactivity AT oliverbracko sensorimotorstrokealtershippocampothalamicnetworkactivity AT andreasrluft sensorimotorstrokealtershippocampothalamicnetworkactivity AT susannewegener sensorimotorstrokealtershippocampothalamicnetworkactivity
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Sensorimotor stroke alters hippocampo-thalamic network activity

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