Cortical complexity in world trade center responders with chronic posttraumatic stress disorder

Abstract Approximately 23% of World Trade Center (WTC) responders are experiencing chronic posttraumatic stress disorder (PTSD) associated with their exposures at the WTC following the terrorist attacks of 9/11/2001, which has been demonstrated to be a risk factor for cognitive impairment raising co...

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Autores principales:	Minos Kritikos, Sean A. P. Clouston, Chuan Huang, Alison C. Pellecchia, Stephanie Mejia-Santiago, Melissa A. Carr, Roman Kotov, Roberto G. Lucchini, Samuel E. Gandy, Evelyn J. Bromet, Benjamin J. Luft
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/e56cafb9707f4f06a4e5843c19f822e0
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spelling	oai:doaj.org-article:e56cafb9707f4f06a4e5843c19f822e02021-11-28T12:09:33ZCortical complexity in world trade center responders with chronic posttraumatic stress disorder10.1038/s41398-021-01719-72158-3188https://doaj.org/article/e56cafb9707f4f06a4e5843c19f822e02021-11-01T00:00:00Zhttps://doi.org/10.1038/s41398-021-01719-7https://doaj.org/toc/2158-3188Abstract Approximately 23% of World Trade Center (WTC) responders are experiencing chronic posttraumatic stress disorder (PTSD) associated with their exposures at the WTC following the terrorist attacks of 9/11/2001, which has been demonstrated to be a risk factor for cognitive impairment raising concerns regarding their brain health. Cortical complexity, as measured by analyzing Fractal Dimension (FD) from T1 MRI brain images, has been reported to be reduced in a variety of psychiatric and neurological conditions. In this report, we hypothesized that FD would be also reduced in a case-control sample of 99 WTC responders as a result of WTC-related PTSD. The results of our surface-based morphometry cluster analysis found alterations in vertex clusters of complexity in WTC responders with PTSD, with marked reductions in regions within the frontal, parietal, and temporal cortices, in addition to whole-brain absolute bilateral and unilateral complexity. Furthermore, region of interest analysis identified that the magnitude of changes in regional FD severity was associated with increased PTSD symptoms (reexperiencing, avoidance, hyperarousal, negative affect) severity. This study confirms prior findings on FD and psychiatric disorders and extends our understanding of FD associations with posttraumatic symptom severity. The complex and traumatic experiences that led to WTC-related PTSD were associated with reductions in cortical complexity. Future work is needed to determine whether reduced cortical complexity arose prior to, or concurrently with, onset of PTSD.Minos KritikosSean A. P. CloustonChuan HuangAlison C. PellecchiaStephanie Mejia-SantiagoMelissa A. CarrRoman KotovRoberto G. LucchiniSamuel E. GandyEvelyn J. BrometBenjamin J. LuftNature Publishing GrouparticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Minos Kritikos Sean A. P. Clouston Chuan Huang Alison C. Pellecchia Stephanie Mejia-Santiago Melissa A. Carr Roman Kotov Roberto G. Lucchini Samuel E. Gandy Evelyn J. Bromet Benjamin J. Luft Cortical complexity in world trade center responders with chronic posttraumatic stress disorder
description	Abstract Approximately 23% of World Trade Center (WTC) responders are experiencing chronic posttraumatic stress disorder (PTSD) associated with their exposures at the WTC following the terrorist attacks of 9/11/2001, which has been demonstrated to be a risk factor for cognitive impairment raising concerns regarding their brain health. Cortical complexity, as measured by analyzing Fractal Dimension (FD) from T1 MRI brain images, has been reported to be reduced in a variety of psychiatric and neurological conditions. In this report, we hypothesized that FD would be also reduced in a case-control sample of 99 WTC responders as a result of WTC-related PTSD. The results of our surface-based morphometry cluster analysis found alterations in vertex clusters of complexity in WTC responders with PTSD, with marked reductions in regions within the frontal, parietal, and temporal cortices, in addition to whole-brain absolute bilateral and unilateral complexity. Furthermore, region of interest analysis identified that the magnitude of changes in regional FD severity was associated with increased PTSD symptoms (reexperiencing, avoidance, hyperarousal, negative affect) severity. This study confirms prior findings on FD and psychiatric disorders and extends our understanding of FD associations with posttraumatic symptom severity. The complex and traumatic experiences that led to WTC-related PTSD were associated with reductions in cortical complexity. Future work is needed to determine whether reduced cortical complexity arose prior to, or concurrently with, onset of PTSD.
format	article
author	Minos Kritikos Sean A. P. Clouston Chuan Huang Alison C. Pellecchia Stephanie Mejia-Santiago Melissa A. Carr Roman Kotov Roberto G. Lucchini Samuel E. Gandy Evelyn J. Bromet Benjamin J. Luft
author_facet	Minos Kritikos Sean A. P. Clouston Chuan Huang Alison C. Pellecchia Stephanie Mejia-Santiago Melissa A. Carr Roman Kotov Roberto G. Lucchini Samuel E. Gandy Evelyn J. Bromet Benjamin J. Luft
author_sort	Minos Kritikos
title	Cortical complexity in world trade center responders with chronic posttraumatic stress disorder
title_short	Cortical complexity in world trade center responders with chronic posttraumatic stress disorder
title_full	Cortical complexity in world trade center responders with chronic posttraumatic stress disorder
title_fullStr	Cortical complexity in world trade center responders with chronic posttraumatic stress disorder
title_full_unstemmed	Cortical complexity in world trade center responders with chronic posttraumatic stress disorder
title_sort	cortical complexity in world trade center responders with chronic posttraumatic stress disorder
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/e56cafb9707f4f06a4e5843c19f822e0
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_version_	1718408171751473152

Cortical complexity in world trade center responders with chronic posttraumatic stress disorder

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