Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved]

Background: Vancomycin is an antibiotic of growing importance in the treatment of hospital-acquired infections; with a particular emphasis on its value in the fight against Methicillin-resistant Staphylococcus aureus. Increasing reports of Vancomycin resistance have raised concerns about the effecti...

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Autores principales:	Tagwa A. M. Salih, Bashir A. Yousef, Mohamed A. M. Salih, Khalid S. Eltom
Formato:	article
Lenguaje:	EN
Publicado:	F1000 Research Ltd 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e56e8117127d43e6b015b7a58efe6d3f
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spelling	oai:doaj.org-article:e56e8117127d43e6b015b7a58efe6d3f2021-11-15T15:26:10ZDrug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved]2046-140210.12688/f1000research.19370.2https://doaj.org/article/e56e8117127d43e6b015b7a58efe6d3f2021-11-01T00:00:00Zhttps://f1000research.com/articles/8-1708/v2https://doaj.org/toc/2046-1402Background: Vancomycin is an antibiotic of growing importance in the treatment of hospital-acquired infections; with a particular emphasis on its value in the fight against Methicillin-resistant Staphylococcus aureus. Increasing reports of Vancomycin resistance have raised concerns about the effectiveness of this drug. Drug utilization evaluation has an important role in controlling rational use of antibiotics to prevent the emergence of resistance. Methods: We conducted a retrospective 6-months study at Jafar Ibn Auf pediatric hospital. Data including patient's demographics, diagnosis, Dosage regimen, and treatment duration were reviewed. The concordance of practice with the Hospital Infection Control Practices Advisory Committee (HICPAC) guidelines and principles of antibiotic therapy was assessed. Results: 127 medical records were reviewed in this study. Sepsis (29%) and Pneumonia (19.6%) were the most common indications. Culture test was requested in 20.5% of patients. Monitoring of serum creatinine was carried in 81.1% of patients. Based on HICPAC guidelines vancomycin was administered appropriately in 67.7% percent of cases. Considering the infusion rate, most of patients with specific order were received vancomycin in 1 hour. Conclusions: The results showed that vancomycin was used empirically without subsequent adjustment of the antimicrobial agent according to culture and sensitivity data and lack of paying enough attention to the infusion rate and serum creatinine monitoring.Tagwa A. M. SalihBashir A. YousefMohamed A. M. SalihKhalid S. EltomF1000 Research LtdarticleMedicineRScienceQENF1000Research, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tagwa A. M. Salih Bashir A. Yousef Mohamed A. M. Salih Khalid S. Eltom Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved]
description	Background: Vancomycin is an antibiotic of growing importance in the treatment of hospital-acquired infections; with a particular emphasis on its value in the fight against Methicillin-resistant Staphylococcus aureus. Increasing reports of Vancomycin resistance have raised concerns about the effectiveness of this drug. Drug utilization evaluation has an important role in controlling rational use of antibiotics to prevent the emergence of resistance. Methods: We conducted a retrospective 6-months study at Jafar Ibn Auf pediatric hospital. Data including patient's demographics, diagnosis, Dosage regimen, and treatment duration were reviewed. The concordance of practice with the Hospital Infection Control Practices Advisory Committee (HICPAC) guidelines and principles of antibiotic therapy was assessed. Results: 127 medical records were reviewed in this study. Sepsis (29%) and Pneumonia (19.6%) were the most common indications. Culture test was requested in 20.5% of patients. Monitoring of serum creatinine was carried in 81.1% of patients. Based on HICPAC guidelines vancomycin was administered appropriately in 67.7% percent of cases. Considering the infusion rate, most of patients with specific order were received vancomycin in 1 hour. Conclusions: The results showed that vancomycin was used empirically without subsequent adjustment of the antimicrobial agent according to culture and sensitivity data and lack of paying enough attention to the infusion rate and serum creatinine monitoring.
format	article
author	Tagwa A. M. Salih Bashir A. Yousef Mohamed A. M. Salih Khalid S. Eltom
author_facet	Tagwa A. M. Salih Bashir A. Yousef Mohamed A. M. Salih Khalid S. Eltom
author_sort	Tagwa A. M. Salih
title	Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved]
title_short	Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved]
title_full	Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved]
title_fullStr	Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved]
title_full_unstemmed	Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved]
title_sort	drug utilization evaluation of vancomycin among patients in jafar ibn auf pediatric hospital, 2018 [version 2; peer review: 2 approved]
publisher	F1000 Research Ltd
publishDate	2021
url	https://doaj.org/article/e56e8117127d43e6b015b7a58efe6d3f
work_keys_str_mv	AT tagwaamsalih drugutilizationevaluationofvancomycinamongpatientsinjafaribnaufpediatrichospital2018version2peerreview2approved AT bashirayousef drugutilizationevaluationofvancomycinamongpatientsinjafaribnaufpediatrichospital2018version2peerreview2approved AT mohamedamsalih drugutilizationevaluationofvancomycinamongpatientsinjafaribnaufpediatrichospital2018version2peerreview2approved AT khalidseltom drugutilizationevaluationofvancomycinamongpatientsinjafaribnaufpediatrichospital2018version2peerreview2approved
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Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved]

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