Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ

Germinal center (GC) is where B cells interact with other immune cells for optimal induction of antibody responses. Here the authors show that galectin-3 regulates GC development by modulating interferon-γ and B cell-intrinsic signaling, such that galectin-3 deficiency mice exhibit lupus-like autoim...

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Autores principales:	Cristian Gabriel Beccaria, María Carolina Amezcua Vesely, Facundo Fiocca Vernengo, Ricardo Carlos Gehrau, María Cecilia Ramello, Jimena Tosello Boari, Melisa Gorosito Serrán, Juan Mucci, Eliane Piaggio, Oscar Campetella, Eva Virginia Acosta Rodríguez, Carolina Lucía Montes, Adriana Gruppi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e56f9c7562ff48e1b8ef2534da1247d2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:e56f9c7562ff48e1b8ef2534da1247d22021-12-02T15:33:35ZGalectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ10.1038/s41467-018-04063-52041-1723https://doaj.org/article/e56f9c7562ff48e1b8ef2534da1247d22018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04063-5https://doaj.org/toc/2041-1723Germinal center (GC) is where B cells interact with other immune cells for optimal induction of antibody responses. Here the authors show that galectin-3 regulates GC development by modulating interferon-γ and B cell-intrinsic signaling, such that galectin-3 deficiency mice exhibit lupus-like autoimmune symptoms.Cristian Gabriel BeccariaMaría Carolina Amezcua VeselyFacundo Fiocca VernengoRicardo Carlos GehrauMaría Cecilia RamelloJimena Tosello BoariMelisa Gorosito SerránJuan MucciEliane PiaggioOscar CampetellaEva Virginia Acosta RodríguezCarolina Lucía MontesAdriana GruppiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cristian Gabriel Beccaria María Carolina Amezcua Vesely Facundo Fiocca Vernengo Ricardo Carlos Gehrau María Cecilia Ramello Jimena Tosello Boari Melisa Gorosito Serrán Juan Mucci Eliane Piaggio Oscar Campetella Eva Virginia Acosta Rodríguez Carolina Lucía Montes Adriana Gruppi Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ
description	Germinal center (GC) is where B cells interact with other immune cells for optimal induction of antibody responses. Here the authors show that galectin-3 regulates GC development by modulating interferon-γ and B cell-intrinsic signaling, such that galectin-3 deficiency mice exhibit lupus-like autoimmune symptoms.
format	article
author	Cristian Gabriel Beccaria María Carolina Amezcua Vesely Facundo Fiocca Vernengo Ricardo Carlos Gehrau María Cecilia Ramello Jimena Tosello Boari Melisa Gorosito Serrán Juan Mucci Eliane Piaggio Oscar Campetella Eva Virginia Acosta Rodríguez Carolina Lucía Montes Adriana Gruppi
author_facet	Cristian Gabriel Beccaria María Carolina Amezcua Vesely Facundo Fiocca Vernengo Ricardo Carlos Gehrau María Cecilia Ramello Jimena Tosello Boari Melisa Gorosito Serrán Juan Mucci Eliane Piaggio Oscar Campetella Eva Virginia Acosta Rodríguez Carolina Lucía Montes Adriana Gruppi
author_sort	Cristian Gabriel Beccaria
title	Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ
title_short	Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ
title_full	Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ
title_fullStr	Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ
title_full_unstemmed	Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ
title_sort	galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via ifn-γ
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e56f9c7562ff48e1b8ef2534da1247d2
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Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ

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