Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1C

Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1C

Abstract Acute myeloid leukemia (AML) is a deadly cancer characterized by an expanded self-renewal capacity that is associated with the accumulation of immature myeloid cells. Emerging evidence shows that methyl-CpG-binding domain protein 2 (MBD2), a DNA methylation reader, often participates in the...

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Autores principales: Kuangguo Zhou, Mi Zhou, Ling Cheng, Xing Chen, Xiaomin Wang, Yajing Chu, Qilin Yu, Shu Zhang, Na Wang, Lei Zhao, Di Wang, Liang Huang, Congyi Wang, Weiping Yuan, Jianfeng Zhou
Formato: article
Lenguaje:EN
Publicado: Nature Publishing Group 2021
Materias:
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/e57105c321a641b28faba3c774324d47
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