High Serum S100A12 Levels Predict Poor Outcome After Acute Primary Intracerebral Hemorrhage

Shen-Zhong Qiu,1 Guan-Rong Zheng,1 Cai-Yan Ma,2 Bin Chen,1 Jian-Jun Huang,1 Ge Huang,1 Hai Hua1 1Department of Neurosurgery, The First People’s Hospital of Fuyang District of Hangzhou City, Hangzhou, People’s Republic of China; 2Department of Clinical Laboratory, The First People’s Hospital of Fuyan...

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Autores principales:	Qiu SZ, Zheng GR, Ma CY, Chen B, Huang JJ, Huang G, Hua H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	biomarker functional outcome inflammation intracerebral hemorrhage early neurological deterioration s100a12 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e57218d3b21a47639be3197b2011cab6
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spelling	oai:doaj.org-article:e57218d3b21a47639be3197b2011cab62021-12-02T19:31:58ZHigh Serum S100A12 Levels Predict Poor Outcome After Acute Primary Intracerebral Hemorrhage1178-2021https://doaj.org/article/e57218d3b21a47639be3197b2011cab62021-11-01T00:00:00Zhttps://www.dovepress.com/high-serum-s100a12-levels-predict-poor-outcome-after-acute-primary-int-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Shen-Zhong Qiu,1 Guan-Rong Zheng,1 Cai-Yan Ma,2 Bin Chen,1 Jian-Jun Huang,1 Ge Huang,1 Hai Hua1 1Department of Neurosurgery, The First People’s Hospital of Fuyang District of Hangzhou City, Hangzhou, People’s Republic of China; 2Department of Clinical Laboratory, The First People’s Hospital of Fuyang District of Hangzhou City, Hangzhou, People’s Republic of ChinaCorrespondence: Hai Hua Tel +86 571 63349039Email huahai1760@163.comObjective: Intracerebral hemorrhage (ICH) triggers an inflammatory cascade that damages brain tissues and worsens functional outcome. S100A12 functions to promote brain inflammation. We aimed to investigate the relationship between serum S100A12 levels and functional outcome in ICH patients.Methods: Serum S100A12 levels were measured in 101 ICH patients hospitalized within 24 h after symptom onset. Poor functional outcome was defined as a modified Rankin scale of 3 or greater at 3 months after stroke. Early neurologic deterioration was defined as an increase of ≥ 4 points in the National Institutes of Health Stroke Scale (NIHSS) score or death at 24 hours from symptoms onset.Results: High serum S100A12 levels were independently correlated with NIHSS score (t = 5.384, P < 0.001), hematoma volume (t = 4.221, P < 0.001) and serum C-reactive protein levels (t = 5.068, P < 0.001). Serum S100A12 levels were substantially higher in patients with a poor outcome (median, 66.5 versus 37.7 ng/mL; P < 0.001) or early neurological deterioration (median, 76.5 versus 40.1 ng/mL; P < 0.001) than in the other remainders, independently predicted a poor outcome (odds ratio, 1.035; 95% confidence interval, 1.007– 1.064; P = 0.015) and early neurologic deterioration (odds ratio,1.032; 95% confidence interval, 1.003– 1.060; P = 0.027), and significantly discriminated a poor outcome (area under curve, 0.794; 95% confidence interval, 0.702– 0.868) and early neurologic deterioration (area under curve, 0.760; 95% confidence interval, 0.664– 0.839) under receiver operating characteristic curve.Conclusion: High serum S100A12 levels at admission are highly associated with the extent of inflammatory response, severity, a poor functional outcome and early neurologic deterioration in ICH patients, substantializing serum S100A12 as a promising prognostic biomarker for ICH.Keywords: biomarker, functional outcome, inflammation, intracerebral hemorrhage, early neurological deterioration, S100A12Qiu SZZheng GRMa CYChen BHuang JJHuang GHua HDove Medical Pressarticlebiomarkerfunctional outcomeinflammationintracerebral hemorrhageearly neurological deteriorations100a12Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 3245-3253 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomarker functional outcome inflammation intracerebral hemorrhage early neurological deterioration s100a12 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	biomarker functional outcome inflammation intracerebral hemorrhage early neurological deterioration s100a12 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Qiu SZ Zheng GR Ma CY Chen B Huang JJ Huang G Hua H High Serum S100A12 Levels Predict Poor Outcome After Acute Primary Intracerebral Hemorrhage
description	Shen-Zhong Qiu,1 Guan-Rong Zheng,1 Cai-Yan Ma,2 Bin Chen,1 Jian-Jun Huang,1 Ge Huang,1 Hai Hua1 1Department of Neurosurgery, The First People’s Hospital of Fuyang District of Hangzhou City, Hangzhou, People’s Republic of China; 2Department of Clinical Laboratory, The First People’s Hospital of Fuyang District of Hangzhou City, Hangzhou, People’s Republic of ChinaCorrespondence: Hai Hua Tel +86 571 63349039Email huahai1760@163.comObjective: Intracerebral hemorrhage (ICH) triggers an inflammatory cascade that damages brain tissues and worsens functional outcome. S100A12 functions to promote brain inflammation. We aimed to investigate the relationship between serum S100A12 levels and functional outcome in ICH patients.Methods: Serum S100A12 levels were measured in 101 ICH patients hospitalized within 24 h after symptom onset. Poor functional outcome was defined as a modified Rankin scale of 3 or greater at 3 months after stroke. Early neurologic deterioration was defined as an increase of ≥ 4 points in the National Institutes of Health Stroke Scale (NIHSS) score or death at 24 hours from symptoms onset.Results: High serum S100A12 levels were independently correlated with NIHSS score (t = 5.384, P < 0.001), hematoma volume (t = 4.221, P < 0.001) and serum C-reactive protein levels (t = 5.068, P < 0.001). Serum S100A12 levels were substantially higher in patients with a poor outcome (median, 66.5 versus 37.7 ng/mL; P < 0.001) or early neurological deterioration (median, 76.5 versus 40.1 ng/mL; P < 0.001) than in the other remainders, independently predicted a poor outcome (odds ratio, 1.035; 95% confidence interval, 1.007– 1.064; P = 0.015) and early neurologic deterioration (odds ratio,1.032; 95% confidence interval, 1.003– 1.060; P = 0.027), and significantly discriminated a poor outcome (area under curve, 0.794; 95% confidence interval, 0.702– 0.868) and early neurologic deterioration (area under curve, 0.760; 95% confidence interval, 0.664– 0.839) under receiver operating characteristic curve.Conclusion: High serum S100A12 levels at admission are highly associated with the extent of inflammatory response, severity, a poor functional outcome and early neurologic deterioration in ICH patients, substantializing serum S100A12 as a promising prognostic biomarker for ICH.Keywords: biomarker, functional outcome, inflammation, intracerebral hemorrhage, early neurological deterioration, S100A12
format	article
author	Qiu SZ Zheng GR Ma CY Chen B Huang JJ Huang G Hua H
author_facet	Qiu SZ Zheng GR Ma CY Chen B Huang JJ Huang G Hua H
author_sort	Qiu SZ
title	High Serum S100A12 Levels Predict Poor Outcome After Acute Primary Intracerebral Hemorrhage
title_short	High Serum S100A12 Levels Predict Poor Outcome After Acute Primary Intracerebral Hemorrhage
title_full	High Serum S100A12 Levels Predict Poor Outcome After Acute Primary Intracerebral Hemorrhage
title_fullStr	High Serum S100A12 Levels Predict Poor Outcome After Acute Primary Intracerebral Hemorrhage
title_full_unstemmed	High Serum S100A12 Levels Predict Poor Outcome After Acute Primary Intracerebral Hemorrhage
title_sort	high serum s100a12 levels predict poor outcome after acute primary intracerebral hemorrhage
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e57218d3b21a47639be3197b2011cab6
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High Serum S100A12 Levels Predict Poor Outcome After Acute Primary Intracerebral Hemorrhage

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