The Multiple Interactions of RUNX with the Hippo–YAP Pathway

The Hippo–YAP signaling pathway serves roles in cell proliferation, stem cell renewal/maintenance, differentiation and apoptosis. Many of its functions are central to early development, adult tissue repair/regeneration and not surprisingly, tumorigenesis and metastasis. The Hippo pathway represses t...

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Autores principales:	Linda Shyue Huey Chuang, Yoshiaki Ito
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	RUNX1 RUNX2 RUNX3 YAP Hippo TAZ Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e57419021f2d45e298e4b58ce8b4b5c1
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id	oai:doaj.org-article:e57419021f2d45e298e4b58ce8b4b5c1
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spelling	oai:doaj.org-article:e57419021f2d45e298e4b58ce8b4b5c12021-11-25T17:08:59ZThe Multiple Interactions of RUNX with the Hippo–YAP Pathway10.3390/cells101129252073-4409https://doaj.org/article/e57419021f2d45e298e4b58ce8b4b5c12021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2925https://doaj.org/toc/2073-4409The Hippo–YAP signaling pathway serves roles in cell proliferation, stem cell renewal/maintenance, differentiation and apoptosis. Many of its functions are central to early development, adult tissue repair/regeneration and not surprisingly, tumorigenesis and metastasis. The Hippo pathway represses the activity of YAP and paralog TAZ by modulating cell proliferation and promoting differentiation to maintain tissue homeostasis and proper organ size. Similarly, master regulators of development RUNX transcription factors have been shown to play critical roles in proliferation, differentiation, apoptosis and cell fate determination. In this review, we discuss the multiple interactions of RUNX with the Hippo–YAP pathway, their shared collaborators in Wnt, TGFβ, MYC and RB pathways, and their overlapping functions in development and tumorigenesis.Linda Shyue Huey ChuangYoshiaki ItoMDPI AGarticleRUNX1RUNX2RUNX3YAPHippoTAZBiology (General)QH301-705.5ENCells, Vol 10, Iss 2925, p 2925 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RUNX1 RUNX2 RUNX3 YAP Hippo TAZ Biology (General) QH301-705.5
spellingShingle	RUNX1 RUNX2 RUNX3 YAP Hippo TAZ Biology (General) QH301-705.5 Linda Shyue Huey Chuang Yoshiaki Ito The Multiple Interactions of RUNX with the Hippo–YAP Pathway
description	The Hippo–YAP signaling pathway serves roles in cell proliferation, stem cell renewal/maintenance, differentiation and apoptosis. Many of its functions are central to early development, adult tissue repair/regeneration and not surprisingly, tumorigenesis and metastasis. The Hippo pathway represses the activity of YAP and paralog TAZ by modulating cell proliferation and promoting differentiation to maintain tissue homeostasis and proper organ size. Similarly, master regulators of development RUNX transcription factors have been shown to play critical roles in proliferation, differentiation, apoptosis and cell fate determination. In this review, we discuss the multiple interactions of RUNX with the Hippo–YAP pathway, their shared collaborators in Wnt, TGFβ, MYC and RB pathways, and their overlapping functions in development and tumorigenesis.
format	article
author	Linda Shyue Huey Chuang Yoshiaki Ito
author_facet	Linda Shyue Huey Chuang Yoshiaki Ito
author_sort	Linda Shyue Huey Chuang
title	The Multiple Interactions of RUNX with the Hippo–YAP Pathway
title_short	The Multiple Interactions of RUNX with the Hippo–YAP Pathway
title_full	The Multiple Interactions of RUNX with the Hippo–YAP Pathway
title_fullStr	The Multiple Interactions of RUNX with the Hippo–YAP Pathway
title_full_unstemmed	The Multiple Interactions of RUNX with the Hippo–YAP Pathway
title_sort	multiple interactions of runx with the hippo–yap pathway
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e57419021f2d45e298e4b58ce8b4b5c1
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The Multiple Interactions of RUNX with the Hippo–YAP Pathway

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