“Wet” transepithelial phototherapeutic keratectomy in the management of persistent epithelial defects in the graft
Sergei V Churashov,1 Elena V Kudryashova,1 Alexei N Kulikov,1 Ernest V Boiko,1–3 Valerii F Chernysh,1 Dmitrii S Maltsev1 1Department of Ophthalmology, Military Medical Academy, St Petersburg, Russia; 2St Petersburg Branch, The S Fyodorov Eye Microsurgery Federal State Institution, St Pete...
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Dove Medical Press
2018
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oai:doaj.org-article:e5796d5db9a1495990c82d7d8f57d7782021-12-02T01:44:12Z“Wet” transepithelial phototherapeutic keratectomy in the management of persistent epithelial defects in the graft1177-5483https://doaj.org/article/e5796d5db9a1495990c82d7d8f57d7782018-05-01T00:00:00Zhttps://www.dovepress.com/wet-transepithelial-phototherapeutic-keratectomy-in-the-management-of-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Sergei V Churashov,1 Elena V Kudryashova,1 Alexei N Kulikov,1 Ernest V Boiko,1–3 Valerii F Chernysh,1 Dmitrii S Maltsev1 1Department of Ophthalmology, Military Medical Academy, St Petersburg, Russia; 2St Petersburg Branch, The S Fyodorov Eye Microsurgery Federal State Institution, St Petersburg, Russia; 3Department of Ophthalmology, Mechnikov North-Western State Medical University, St Petersburg, Russia Purpose: This study aimed to evaluate the efficacy of “wet” transepithelial phototherapeutic keratectomy (TE-PTK) for treating persistent epithelial defects (PEDs) in the corneal graft following penetrating keratoplasty (PKP).Methods: This study describes a noncomparative, prospective interventional case series. Patients with post-PKP graft epithelial defects lasting >3 months despite previous treatments with extensive wear soft contact lenses, amniotic membrane transplantation, and tarsorrhaphy were treated with wet TE-PTK. A wet TE-PTK procedure including a “wet ablation” step was performed using the EC-5000 excimer laser. Follow-up visits were at post-PTK days 3, 5, 10, and 30, and at each month thereafter.Results: Eight patients (8 eyes; 5 men and 3 women; mean age, 51.3±14.3 years; mean follow-up period, 9.1±3.0 months) were included in this study. The mean best-corrected visual acuity was 1.76±0.28 log minimum angle of resolution (logMAR) at baseline and improved to 1.1±0.22 logMAR at 10 days postoperatively (p=0.0156; the improvement was significant). This effect remained stable throughout the remainder of the follow-up period. The mean time from wet TE-PTK to complete reepithelization was 4.3±1.3 days.Conclusion: Wet TE-PTK appears to be effective for patients with post-PKP PEDs in the corneal graft who have failed conservative measures or previous surgical interventions. Keywords: phototherapeutic keratectomy, persistent epithelial defects, penetrating keratoplasty, transepithelial phototherapeutic keratectomy, recurrent corneal erosionChurashov SVKudryashova EVKulikov ANBoiko EVChernysh VFMaltsev DSDove Medical Pressarticlephototherapeutic keratectomypersistent epithelial defectspenetrating keratoplastytransepithelial phototherapeutic keratectomyrecurrent corneal erosionOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 895-901 (2018) |
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phototherapeutic keratectomy persistent epithelial defects penetrating keratoplasty transepithelial phototherapeutic keratectomy recurrent corneal erosion Ophthalmology RE1-994 |
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phototherapeutic keratectomy persistent epithelial defects penetrating keratoplasty transepithelial phototherapeutic keratectomy recurrent corneal erosion Ophthalmology RE1-994 Churashov SV Kudryashova EV Kulikov AN Boiko EV Chernysh VF Maltsev DS “Wet” transepithelial phototherapeutic keratectomy in the management of persistent epithelial defects in the graft |
| description |
Sergei V Churashov,1 Elena V Kudryashova,1 Alexei N Kulikov,1 Ernest V Boiko,1–3 Valerii F Chernysh,1 Dmitrii S Maltsev1 1Department of Ophthalmology, Military Medical Academy, St Petersburg, Russia; 2St Petersburg Branch, The S Fyodorov Eye Microsurgery Federal State Institution, St Petersburg, Russia; 3Department of Ophthalmology, Mechnikov North-Western State Medical University, St Petersburg, Russia Purpose: This study aimed to evaluate the efficacy of “wet” transepithelial phototherapeutic keratectomy (TE-PTK) for treating persistent epithelial defects (PEDs) in the corneal graft following penetrating keratoplasty (PKP).Methods: This study describes a noncomparative, prospective interventional case series. Patients with post-PKP graft epithelial defects lasting >3 months despite previous treatments with extensive wear soft contact lenses, amniotic membrane transplantation, and tarsorrhaphy were treated with wet TE-PTK. A wet TE-PTK procedure including a “wet ablation” step was performed using the EC-5000 excimer laser. Follow-up visits were at post-PTK days 3, 5, 10, and 30, and at each month thereafter.Results: Eight patients (8 eyes; 5 men and 3 women; mean age, 51.3±14.3 years; mean follow-up period, 9.1±3.0 months) were included in this study. The mean best-corrected visual acuity was 1.76±0.28 log minimum angle of resolution (logMAR) at baseline and improved to 1.1±0.22 logMAR at 10 days postoperatively (p=0.0156; the improvement was significant). This effect remained stable throughout the remainder of the follow-up period. The mean time from wet TE-PTK to complete reepithelization was 4.3±1.3 days.Conclusion: Wet TE-PTK appears to be effective for patients with post-PKP PEDs in the corneal graft who have failed conservative measures or previous surgical interventions. Keywords: phototherapeutic keratectomy, persistent epithelial defects, penetrating keratoplasty, transepithelial phototherapeutic keratectomy, recurrent corneal erosion |
| format |
article |
| author |
Churashov SV Kudryashova EV Kulikov AN Boiko EV Chernysh VF Maltsev DS |
| author_facet |
Churashov SV Kudryashova EV Kulikov AN Boiko EV Chernysh VF Maltsev DS |
| author_sort |
Churashov SV |
| title |
“Wet” transepithelial phototherapeutic keratectomy in the management of persistent epithelial defects in the graft |
| title_short |
“Wet” transepithelial phototherapeutic keratectomy in the management of persistent epithelial defects in the graft |
| title_full |
“Wet” transepithelial phototherapeutic keratectomy in the management of persistent epithelial defects in the graft |
| title_fullStr |
“Wet” transepithelial phototherapeutic keratectomy in the management of persistent epithelial defects in the graft |
| title_full_unstemmed |
“Wet” transepithelial phototherapeutic keratectomy in the management of persistent epithelial defects in the graft |
| title_sort |
“wet” transepithelial phototherapeutic keratectomy in the management of persistent epithelial defects in the graft |
| publisher |
Dove Medical Press |
| publishDate |
2018 |
| url |
https://doaj.org/article/e5796d5db9a1495990c82d7d8f57d778 |
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