Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p

Platelets derive from megakaryocytes, which differentiate from hematopoietic stem/progenitor cells (HSPCs). Here, Qu et al show that platelet-derived microparticles carrying miR-1915-3p target HSPCs and promote megakaryopoiesis by suppressing RHOB expression levels.

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Autores principales:	Mingyi Qu, Xiaojing Zou, Fang Fang, Shouye Wang, Lei Xu, Quan Zeng, Zeng Fan, Lin Chen, Wen Yue, Xiaoyan Xie, Xuetao Pei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e57a2830508e4d669bbe1eecb90e8c32
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spelling	oai:doaj.org-article:e57a2830508e4d669bbe1eecb90e8c322021-12-02T17:18:08ZPlatelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p10.1038/s41467-020-18802-02041-1723https://doaj.org/article/e57a2830508e4d669bbe1eecb90e8c322020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18802-0https://doaj.org/toc/2041-1723Platelets derive from megakaryocytes, which differentiate from hematopoietic stem/progenitor cells (HSPCs). Here, Qu et al show that platelet-derived microparticles carrying miR-1915-3p target HSPCs and promote megakaryopoiesis by suppressing RHOB expression levels.Mingyi QuXiaojing ZouFang FangShouye WangLei XuQuan ZengZeng FanLin ChenWen YueXiaoyan XieXuetao PeiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mingyi Qu Xiaojing Zou Fang Fang Shouye Wang Lei Xu Quan Zeng Zeng Fan Lin Chen Wen Yue Xiaoyan Xie Xuetao Pei Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p
description	Platelets derive from megakaryocytes, which differentiate from hematopoietic stem/progenitor cells (HSPCs). Here, Qu et al show that platelet-derived microparticles carrying miR-1915-3p target HSPCs and promote megakaryopoiesis by suppressing RHOB expression levels.
format	article
author	Mingyi Qu Xiaojing Zou Fang Fang Shouye Wang Lei Xu Quan Zeng Zeng Fan Lin Chen Wen Yue Xiaoyan Xie Xuetao Pei
author_facet	Mingyi Qu Xiaojing Zou Fang Fang Shouye Wang Lei Xu Quan Zeng Zeng Fan Lin Chen Wen Yue Xiaoyan Xie Xuetao Pei
author_sort	Mingyi Qu
title	Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p
title_short	Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p
title_full	Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p
title_fullStr	Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p
title_full_unstemmed	Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p
title_sort	platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via mir-1915-3p
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e57a2830508e4d669bbe1eecb90e8c32
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Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p

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