Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study

Chronic obstructive pulmonary disease (COPD) is a complex condition in which systemic inflammation plays a role in extrapulmonary manifestations, including cardiovascular diseases: interleukin (IL)-6 has a role in both COPD and atherogenesis. The 2011 GOLD document classified patients according to F...

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Autores principales:	Dario Nieri, Marta Daniele, Stefania Lombardi, Erica Bazzan, Sabrina Santerini, Giovanna De Cusatis, Barbara Vagaggini, Manuel G. Cosio, Marina Saetta, Pierluigi Paggiaro, Alessandro Celi, Tommaso Neri
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chronic obstructive pulmonary disease extracellular vesicles systemic inflammation endothelium Medicine R
Acceso en línea:	https://doaj.org/article/e57be7265e38467796d098b0e87bb260
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spelling	oai:doaj.org-article:e57be7265e38467796d098b0e87bb2602021-11-11T17:38:42ZCirculating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study10.3390/jcm102150142077-0383https://doaj.org/article/e57be7265e38467796d098b0e87bb2602021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5014https://doaj.org/toc/2077-0383Chronic obstructive pulmonary disease (COPD) is a complex condition in which systemic inflammation plays a role in extrapulmonary manifestations, including cardiovascular diseases: interleukin (IL)-6 has a role in both COPD and atherogenesis. The 2011 GOLD document classified patients according to FEV1, symptoms, and exacerbations history, creating four groups, from A (less symptoms/low risk) to D (more symptoms/high risk). Extracellular vesicles (EV) represent potential markers in COPD: nevertheless, no studies have explored their value in association to both disease severity and inflammation. We conducted a pilot study to analyze circulating endothelial-(E) and monocyte-derived (M) EV levels in 35 COPD patients, who were grouped according to the 2011 GOLD document; the relationship between EV and plasmatic markers of inflammation was analyzed. We found a statistically significant trend for increasing EEV, MEV, IL-6, from group A to D, and a significant correlation between EEV and IL-6. The associations between both EEV and MEV and disease severity, and between EEV and IL-6, suggest a significant interplay between pulmonary disease and inflammation, with non-respiratory cells (endothelial cells and monocytes) involvement, along with the progression of the disease. Thus, EV might help identify a high-risk population for extrapulmonary events, especially in the most severe patients.Dario NieriMarta DanieleStefania LombardiErica BazzanSabrina SanteriniGiovanna De CusatisBarbara VagagginiManuel G. CosioMarina SaettaPierluigi PaggiaroAlessandro CeliTommaso NeriMDPI AGarticlechronic obstructive pulmonary diseaseextracellular vesiclessystemic inflammationendotheliumMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5014, p 5014 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic obstructive pulmonary disease extracellular vesicles systemic inflammation endothelium Medicine R
spellingShingle	chronic obstructive pulmonary disease extracellular vesicles systemic inflammation endothelium Medicine R Dario Nieri Marta Daniele Stefania Lombardi Erica Bazzan Sabrina Santerini Giovanna De Cusatis Barbara Vagaggini Manuel G. Cosio Marina Saetta Pierluigi Paggiaro Alessandro Celi Tommaso Neri Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study
description	Chronic obstructive pulmonary disease (COPD) is a complex condition in which systemic inflammation plays a role in extrapulmonary manifestations, including cardiovascular diseases: interleukin (IL)-6 has a role in both COPD and atherogenesis. The 2011 GOLD document classified patients according to FEV1, symptoms, and exacerbations history, creating four groups, from A (less symptoms/low risk) to D (more symptoms/high risk). Extracellular vesicles (EV) represent potential markers in COPD: nevertheless, no studies have explored their value in association to both disease severity and inflammation. We conducted a pilot study to analyze circulating endothelial-(E) and monocyte-derived (M) EV levels in 35 COPD patients, who were grouped according to the 2011 GOLD document; the relationship between EV and plasmatic markers of inflammation was analyzed. We found a statistically significant trend for increasing EEV, MEV, IL-6, from group A to D, and a significant correlation between EEV and IL-6. The associations between both EEV and MEV and disease severity, and between EEV and IL-6, suggest a significant interplay between pulmonary disease and inflammation, with non-respiratory cells (endothelial cells and monocytes) involvement, along with the progression of the disease. Thus, EV might help identify a high-risk population for extrapulmonary events, especially in the most severe patients.
format	article
author	Dario Nieri Marta Daniele Stefania Lombardi Erica Bazzan Sabrina Santerini Giovanna De Cusatis Barbara Vagaggini Manuel G. Cosio Marina Saetta Pierluigi Paggiaro Alessandro Celi Tommaso Neri
author_facet	Dario Nieri Marta Daniele Stefania Lombardi Erica Bazzan Sabrina Santerini Giovanna De Cusatis Barbara Vagaggini Manuel G. Cosio Marina Saetta Pierluigi Paggiaro Alessandro Celi Tommaso Neri
author_sort	Dario Nieri
title	Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study
title_short	Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study
title_full	Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study
title_fullStr	Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study
title_full_unstemmed	Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study
title_sort	circulating extracellular vesicles are associated with disease severity and interleukin-6 levels in copd: a pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e57be7265e38467796d098b0e87bb260
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Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study

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