A Prospective Comparative Study of Using Ultrasonography, 4D-CT and Parathyroid Dual-Phase Scintigraphy with SPECT in Patients with Primary Hyperparathyroidism

Thirty-one consecutive patients were included in this study who were planned for parathyroidectomy due to primary hyperparathyroidism. They were studied with US, 4D-CT and dual-phase scintigraphy including SPECT/CT, and possible adenomas were identified in each imaging modality. Imaging data were qu...

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Autores principales:	Kalevi Kairemo, Aaron C. Jessop, A. Hans Vija, Xinhong Ding, Don Spence, S. Cheenu Kappadath, Homer A. Macapinlac
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	parathyroid imaging 4D-CT SPECT/CT <sup>99m</sup>Tc -MIBI hyperparathyroidism parathyroid adenoma Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e57c3cbcec974b84ab70a8f21bc7efd4
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spelling	oai:doaj.org-article:e57c3cbcec974b84ab70a8f21bc7efd42021-11-25T17:20:41ZA Prospective Comparative Study of Using Ultrasonography, 4D-CT and Parathyroid Dual-Phase Scintigraphy with SPECT in Patients with Primary Hyperparathyroidism10.3390/diagnostics111120062075-4418https://doaj.org/article/e57c3cbcec974b84ab70a8f21bc7efd42021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2006https://doaj.org/toc/2075-4418Thirty-one consecutive patients were included in this study who were planned for parathyroidectomy due to primary hyperparathyroidism. They were studied with US, 4D-CT and dual-phase scintigraphy including SPECT/CT, and possible adenomas were identified in each imaging modality. Imaging data were quantified with US, CT and SPECT. Parathyroidectomies were performed as minimally invasive according to preoperative imaging findings. A total of 16 adenomas were found in 15 patients, and the surgery was negative in four patients. The imaging results were compared with each other and correlated to histology findings and blood biochemistry (S-Ca and P-PTH). Quantitative SPECT found a strong correlation between the quantification methods—Conjugate Gradient with Attenuation and Scatter Correction with a zone map (CGZAS) and Conjugate Gradient with Attenuation and Scatter Correction (CGAS)—measured as SUVmax and kBq/mL. However, a statistically significant correlation between the quantitative parameters (CGZAS and CGAS) and serum biomarkers (S-PTH and S-Ca) was not observed. The sensitivities of the imaging methods were calculated using histopathology as a gold standard. SPECT/CT demonstrated 93% sensitivity, 4D-CT 93% sensitivity and ultrasonography 73% sensitivity. The imaging methods were compared with each other using parathyroid regions because findings and locations varied between the modalities. Our prospective study supports that quantitative SPECT/CT is useful for presurgical assessment of primary hyperparathyroidism.Kalevi KairemoAaron C. JessopA. Hans VijaXinhong DingDon SpenceS. Cheenu KappadathHomer A. MacapinlacMDPI AGarticleparathyroid imaging4D-CTSPECT/CT<sup>99m</sup>Tc -MIBIhyperparathyroidismparathyroid adenomaMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2006, p 2006 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	parathyroid imaging 4D-CT SPECT/CT <sup>99m</sup>Tc -MIBI hyperparathyroidism parathyroid adenoma Medicine (General) R5-920
spellingShingle	parathyroid imaging 4D-CT SPECT/CT <sup>99m</sup>Tc -MIBI hyperparathyroidism parathyroid adenoma Medicine (General) R5-920 Kalevi Kairemo Aaron C. Jessop A. Hans Vija Xinhong Ding Don Spence S. Cheenu Kappadath Homer A. Macapinlac A Prospective Comparative Study of Using Ultrasonography, 4D-CT and Parathyroid Dual-Phase Scintigraphy with SPECT in Patients with Primary Hyperparathyroidism
description	Thirty-one consecutive patients were included in this study who were planned for parathyroidectomy due to primary hyperparathyroidism. They were studied with US, 4D-CT and dual-phase scintigraphy including SPECT/CT, and possible adenomas were identified in each imaging modality. Imaging data were quantified with US, CT and SPECT. Parathyroidectomies were performed as minimally invasive according to preoperative imaging findings. A total of 16 adenomas were found in 15 patients, and the surgery was negative in four patients. The imaging results were compared with each other and correlated to histology findings and blood biochemistry (S-Ca and P-PTH). Quantitative SPECT found a strong correlation between the quantification methods—Conjugate Gradient with Attenuation and Scatter Correction with a zone map (CGZAS) and Conjugate Gradient with Attenuation and Scatter Correction (CGAS)—measured as SUVmax and kBq/mL. However, a statistically significant correlation between the quantitative parameters (CGZAS and CGAS) and serum biomarkers (S-PTH and S-Ca) was not observed. The sensitivities of the imaging methods were calculated using histopathology as a gold standard. SPECT/CT demonstrated 93% sensitivity, 4D-CT 93% sensitivity and ultrasonography 73% sensitivity. The imaging methods were compared with each other using parathyroid regions because findings and locations varied between the modalities. Our prospective study supports that quantitative SPECT/CT is useful for presurgical assessment of primary hyperparathyroidism.
format	article
author	Kalevi Kairemo Aaron C. Jessop A. Hans Vija Xinhong Ding Don Spence S. Cheenu Kappadath Homer A. Macapinlac
author_facet	Kalevi Kairemo Aaron C. Jessop A. Hans Vija Xinhong Ding Don Spence S. Cheenu Kappadath Homer A. Macapinlac
author_sort	Kalevi Kairemo
title	A Prospective Comparative Study of Using Ultrasonography, 4D-CT and Parathyroid Dual-Phase Scintigraphy with SPECT in Patients with Primary Hyperparathyroidism
title_short	A Prospective Comparative Study of Using Ultrasonography, 4D-CT and Parathyroid Dual-Phase Scintigraphy with SPECT in Patients with Primary Hyperparathyroidism
title_full	A Prospective Comparative Study of Using Ultrasonography, 4D-CT and Parathyroid Dual-Phase Scintigraphy with SPECT in Patients with Primary Hyperparathyroidism
title_fullStr	A Prospective Comparative Study of Using Ultrasonography, 4D-CT and Parathyroid Dual-Phase Scintigraphy with SPECT in Patients with Primary Hyperparathyroidism
title_full_unstemmed	A Prospective Comparative Study of Using Ultrasonography, 4D-CT and Parathyroid Dual-Phase Scintigraphy with SPECT in Patients with Primary Hyperparathyroidism
title_sort	prospective comparative study of using ultrasonography, 4d-ct and parathyroid dual-phase scintigraphy with spect in patients with primary hyperparathyroidism
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e57c3cbcec974b84ab70a8f21bc7efd4
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A Prospective Comparative Study of Using Ultrasonography, 4D-CT and Parathyroid Dual-Phase Scintigraphy with SPECT in Patients with Primary Hyperparathyroidism

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