A dietary fatty acid counteracts neuronal mechanical sensitization

PIEZO2 is a critical component of the mechanism by which innocuous touch causes pain (tactile allodynia). Here, authors find that the dietary fatty acid margaric acid decreases PIEZO2 function in a dose-dependent manner and counteracts neuronal mechanical sensitization by a proalgesic agent.

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Autores principales:	Luis O. Romero, Rebeca Caires, Alec R. Nickolls, Alexander T. Chesler, Julio F. Cordero-Morales, Valeria Vásquez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e581e953bfe048c495f317467c7b666c
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spelling	oai:doaj.org-article:e581e953bfe048c495f317467c7b666c2021-12-02T16:04:17ZA dietary fatty acid counteracts neuronal mechanical sensitization10.1038/s41467-020-16816-22041-1723https://doaj.org/article/e581e953bfe048c495f317467c7b666c2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16816-2https://doaj.org/toc/2041-1723PIEZO2 is a critical component of the mechanism by which innocuous touch causes pain (tactile allodynia). Here, authors find that the dietary fatty acid margaric acid decreases PIEZO2 function in a dose-dependent manner and counteracts neuronal mechanical sensitization by a proalgesic agent.Luis O. RomeroRebeca CairesAlec R. NickollsAlexander T. CheslerJulio F. Cordero-MoralesValeria VásquezNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luis O. Romero Rebeca Caires Alec R. Nickolls Alexander T. Chesler Julio F. Cordero-Morales Valeria Vásquez A dietary fatty acid counteracts neuronal mechanical sensitization
description	PIEZO2 is a critical component of the mechanism by which innocuous touch causes pain (tactile allodynia). Here, authors find that the dietary fatty acid margaric acid decreases PIEZO2 function in a dose-dependent manner and counteracts neuronal mechanical sensitization by a proalgesic agent.
format	article
author	Luis O. Romero Rebeca Caires Alec R. Nickolls Alexander T. Chesler Julio F. Cordero-Morales Valeria Vásquez
author_facet	Luis O. Romero Rebeca Caires Alec R. Nickolls Alexander T. Chesler Julio F. Cordero-Morales Valeria Vásquez
author_sort	Luis O. Romero
title	A dietary fatty acid counteracts neuronal mechanical sensitization
title_short	A dietary fatty acid counteracts neuronal mechanical sensitization
title_full	A dietary fatty acid counteracts neuronal mechanical sensitization
title_fullStr	A dietary fatty acid counteracts neuronal mechanical sensitization
title_full_unstemmed	A dietary fatty acid counteracts neuronal mechanical sensitization
title_sort	dietary fatty acid counteracts neuronal mechanical sensitization
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e581e953bfe048c495f317467c7b666c
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A dietary fatty acid counteracts neuronal mechanical sensitization

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