Regional Variation in Dengue Virus Serotypes in Sri Lanka and Its Clinical and Epidemiological Relevance

Dengue is a significant health concern in Sri Lanka, but diagnosis of the infecting dengue virus (DENV) serotype has hitherto been largely restricted to the Colombo district in the western province. Salinity tolerant <i>Aedes</i> vectors are present in the island’s northern Jaffna penins...

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Autores principales:	Tibutius T. P. Jayadas, Thirunavukarasu Kumanan, Laksiri Gomes, Chandima Jeewandara, Gathsaurie N. Malavige, Diyanath Ranasinghe, Ramesh S. Jadi, Ranjan Ramasamy, Sinnathamby N. Surendran
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	clinical manifestations of dengue Colombo district dengue diagnosis dengue epidemiology dengue virus serotypes dengue virus genotypes Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e582a3d5e66249a2ae17ceac519889a8
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spelling	oai:doaj.org-article:e582a3d5e66249a2ae17ceac519889a82021-11-25T17:21:30ZRegional Variation in Dengue Virus Serotypes in Sri Lanka and Its Clinical and Epidemiological Relevance10.3390/diagnostics111120842075-4418https://doaj.org/article/e582a3d5e66249a2ae17ceac519889a82021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2084https://doaj.org/toc/2075-4418Dengue is a significant health concern in Sri Lanka, but diagnosis of the infecting dengue virus (DENV) serotype has hitherto been largely restricted to the Colombo district in the western province. Salinity tolerant <i>Aedes</i> vectors are present in the island’s northern Jaffna peninsula, which is undergoing rapid groundwater salinization. Virus serotypes were determined by RT-qPCR in 107 and 112 patients diagnosed by NS1 antigen positivity from the Jaffna district in 2018 and 2019, respectively, and related to clinical characteristics. DENV1 and DENV2 were the most common serotypes in both years. Infections with multiple serotypes were not detected. DENV1 was significantly more prevalent in 2019 than 2018, while DENV3 was significantly more prevalent in 2018 than 2019 among the Jaffna patients. Limited genomic sequencing identified DENV1 genotype-I and DENV3 genotype-I in Jaffna patients in 2018. Dengue was more prevalent in working age persons and males among the serotyped Jaffna patients. DENV1 and DENV2 were the predominant serotypes in 2019 in the Colombo district. However, DENV1 and DENV3 were significantly more prevalent in Colombo compared with Jaffna in 2019. The differences in the prevalence of DENV1 and DENV3 between the Jaffna and Colombo districts in 2019 have implications for dengue epidemiology and vaccination. Salinity-tolerant <i>Aedes</i> vector strains, widespread in the Jaffna peninsula, may have contributed to differences in serotype prevalence compared with the Colombo district in 2019. Significant associations were not identified between virus serotypes and clinical characteristics among Jaffna patients.Tibutius T. P. JayadasThirunavukarasu KumananLaksiri GomesChandima JeewandaraGathsaurie N. MalavigeDiyanath RanasingheRamesh S. JadiRanjan RamasamySinnathamby N. SurendranMDPI AGarticleclinical manifestations of dengueColombo districtdengue diagnosisdengue epidemiologydengue virus serotypesdengue virus genotypesMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2084, p 2084 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clinical manifestations of dengue Colombo district dengue diagnosis dengue epidemiology dengue virus serotypes dengue virus genotypes Medicine (General) R5-920
spellingShingle	clinical manifestations of dengue Colombo district dengue diagnosis dengue epidemiology dengue virus serotypes dengue virus genotypes Medicine (General) R5-920 Tibutius T. P. Jayadas Thirunavukarasu Kumanan Laksiri Gomes Chandima Jeewandara Gathsaurie N. Malavige Diyanath Ranasinghe Ramesh S. Jadi Ranjan Ramasamy Sinnathamby N. Surendran Regional Variation in Dengue Virus Serotypes in Sri Lanka and Its Clinical and Epidemiological Relevance
description	Dengue is a significant health concern in Sri Lanka, but diagnosis of the infecting dengue virus (DENV) serotype has hitherto been largely restricted to the Colombo district in the western province. Salinity tolerant <i>Aedes</i> vectors are present in the island’s northern Jaffna peninsula, which is undergoing rapid groundwater salinization. Virus serotypes were determined by RT-qPCR in 107 and 112 patients diagnosed by NS1 antigen positivity from the Jaffna district in 2018 and 2019, respectively, and related to clinical characteristics. DENV1 and DENV2 were the most common serotypes in both years. Infections with multiple serotypes were not detected. DENV1 was significantly more prevalent in 2019 than 2018, while DENV3 was significantly more prevalent in 2018 than 2019 among the Jaffna patients. Limited genomic sequencing identified DENV1 genotype-I and DENV3 genotype-I in Jaffna patients in 2018. Dengue was more prevalent in working age persons and males among the serotyped Jaffna patients. DENV1 and DENV2 were the predominant serotypes in 2019 in the Colombo district. However, DENV1 and DENV3 were significantly more prevalent in Colombo compared with Jaffna in 2019. The differences in the prevalence of DENV1 and DENV3 between the Jaffna and Colombo districts in 2019 have implications for dengue epidemiology and vaccination. Salinity-tolerant <i>Aedes</i> vector strains, widespread in the Jaffna peninsula, may have contributed to differences in serotype prevalence compared with the Colombo district in 2019. Significant associations were not identified between virus serotypes and clinical characteristics among Jaffna patients.
format	article
author	Tibutius T. P. Jayadas Thirunavukarasu Kumanan Laksiri Gomes Chandima Jeewandara Gathsaurie N. Malavige Diyanath Ranasinghe Ramesh S. Jadi Ranjan Ramasamy Sinnathamby N. Surendran
author_facet	Tibutius T. P. Jayadas Thirunavukarasu Kumanan Laksiri Gomes Chandima Jeewandara Gathsaurie N. Malavige Diyanath Ranasinghe Ramesh S. Jadi Ranjan Ramasamy Sinnathamby N. Surendran
author_sort	Tibutius T. P. Jayadas
title	Regional Variation in Dengue Virus Serotypes in Sri Lanka and Its Clinical and Epidemiological Relevance
title_short	Regional Variation in Dengue Virus Serotypes in Sri Lanka and Its Clinical and Epidemiological Relevance
title_full	Regional Variation in Dengue Virus Serotypes in Sri Lanka and Its Clinical and Epidemiological Relevance
title_fullStr	Regional Variation in Dengue Virus Serotypes in Sri Lanka and Its Clinical and Epidemiological Relevance
title_full_unstemmed	Regional Variation in Dengue Virus Serotypes in Sri Lanka and Its Clinical and Epidemiological Relevance
title_sort	regional variation in dengue virus serotypes in sri lanka and its clinical and epidemiological relevance
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e582a3d5e66249a2ae17ceac519889a8
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Regional Variation in Dengue Virus Serotypes in Sri Lanka and Its Clinical and Epidemiological Relevance

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