Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging

Tomov et al. utilize DNA-PRISM to allow for multiplexed imaging of cultured cells using antibodies modified with oligonucleotide probes. The differentiation of iPSCs to cortical and motor neurons is characterized in model cultures, relevant for use in disease research and drug screening.

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Autores principales:	Martin L. Tomov, Alison O’Neil, Hamdah S. Abbasi, Beth A. Cimini, Anne E. Carpenter, Lee L. Rubin, Mark Bathe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e582b76ab1df483bb47189a7a60c84ee
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spelling	oai:doaj.org-article:e582b76ab1df483bb47189a7a60c84ee2021-12-02T18:02:53ZResolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging10.1038/s42003-021-02276-x2399-3642https://doaj.org/article/e582b76ab1df483bb47189a7a60c84ee2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02276-xhttps://doaj.org/toc/2399-3642Tomov et al. utilize DNA-PRISM to allow for multiplexed imaging of cultured cells using antibodies modified with oligonucleotide probes. The differentiation of iPSCs to cortical and motor neurons is characterized in model cultures, relevant for use in disease research and drug screening.Martin L. TomovAlison O’NeilHamdah S. AbbasiBeth A. CiminiAnne E. CarpenterLee L. RubinMark BatheNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Martin L. Tomov Alison O’Neil Hamdah S. Abbasi Beth A. Cimini Anne E. Carpenter Lee L. Rubin Mark Bathe Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging
description	Tomov et al. utilize DNA-PRISM to allow for multiplexed imaging of cultured cells using antibodies modified with oligonucleotide probes. The differentiation of iPSCs to cortical and motor neurons is characterized in model cultures, relevant for use in disease research and drug screening.
format	article
author	Martin L. Tomov Alison O’Neil Hamdah S. Abbasi Beth A. Cimini Anne E. Carpenter Lee L. Rubin Mark Bathe
author_facet	Martin L. Tomov Alison O’Neil Hamdah S. Abbasi Beth A. Cimini Anne E. Carpenter Lee L. Rubin Mark Bathe
author_sort	Martin L. Tomov
title	Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging
title_short	Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging
title_full	Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging
title_fullStr	Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging
title_full_unstemmed	Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging
title_sort	resolving cell state in ipsc-derived human neural samples with multiplexed fluorescence imaging
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e582b76ab1df483bb47189a7a60c84ee
work_keys_str_mv	AT martinltomov resolvingcellstateinipscderivedhumanneuralsampleswithmultiplexedfluorescenceimaging AT alisononeil resolvingcellstateinipscderivedhumanneuralsampleswithmultiplexedfluorescenceimaging AT hamdahsabbasi resolvingcellstateinipscderivedhumanneuralsampleswithmultiplexedfluorescenceimaging AT bethacimini resolvingcellstateinipscderivedhumanneuralsampleswithmultiplexedfluorescenceimaging AT anneecarpenter resolvingcellstateinipscderivedhumanneuralsampleswithmultiplexedfluorescenceimaging AT leelrubin resolvingcellstateinipscderivedhumanneuralsampleswithmultiplexedfluorescenceimaging AT markbathe resolvingcellstateinipscderivedhumanneuralsampleswithmultiplexedfluorescenceimaging
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Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging

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