Intrasound therapy in tendon healing: is intensity a factor?

AI Aiyegbusi1, FIO Duru1, SR Akinbo2, CC Noronha1, AO Okanlawon11Departments of Anatomy and 2Physiotherapy, College of Medicine, University of Lagos, Lagos, NigeriaObjective: This study investigated the effects of low- and high-intensity intrasound therapy (LITR and HITR, respectively) given once da...

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Autores principales:	AI Aiyegbusi, FIO Duru, SR Akinbo, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/e585827ee4dc48ec81e57cc457810feb
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spelling	oai:doaj.org-article:e585827ee4dc48ec81e57cc457810feb2021-12-02T01:14:42ZIntrasound therapy in tendon healing: is intensity a factor?1179-156Xhttps://doaj.org/article/e585827ee4dc48ec81e57cc457810feb2010-08-01T00:00:00Zhttp://www.dovepress.com/intrasound-therapy-in-tendon-healing-is-intensity-a-factor-a5029https://doaj.org/toc/1179-156XAI Aiyegbusi1, FIO Duru1, SR Akinbo2, CC Noronha1, AO Okanlawon11Departments of Anatomy and 2Physiotherapy, College of Medicine, University of Lagos, Lagos, NigeriaObjective: This study investigated the effects of low- and high-intensity intrasound therapy (LITR and HITR, respectively) given once daily and twice daily on the morphology and &shy;oxidative stress in healing tendon tissue following an acute injury.Methods: Eighty-five male rats, randomized into six groups were further subdivided into groups A, B, and C, except for Group 1 which was subdivided into A and B only. Groups 2&ndash;6 underwent an induced crush injury. The six groups were allocated to: serve as controls (Group 1), receive no treatment (Group 2), HITR twice daily (Group 3), HITR once daily (Group 4), LITR twice daily (Group 5), and LITR once daily (Group 6). Intrasound therapy (ITR) was commenced 24 hours postinjury and was given once daily or twice daily over the first 14 days postinjury. The animals in subgroups A and B were sacrificed on day 15 postinjury, and those in subgroup C were sacrificed on day 31 postinjury. The tendons were excised, and processed for histology and malondialdehyde (MDA) assay.Results: There was no significant difference in the tenocyte population between the HITR- and LITR-treated groups. However, twice-daily treatment in either the low- or high-intensity mode resulted in significant tenocyte proliferation compared with the once-daily treated groups, and also had the highest percentage of tenoblasts compared with the population of tenocytes in the proliferative phase of healing. All treatment protocols marginally lowered the MDA level.Conclusion: The role of IRT in tendon healing is influenced more by the frequency of treatment rather than the intensity of the delivered dosage.Keywords: intrasound therapy, tenoblast, tenocytes, tendon injury, crush injury, oxidative stress, malondialdehyde, tenoblast proliferation. AI AiyegbusiFIO DuruSR Akinboet alDove Medical PressarticleDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol 2010, Iss default, Pp 45-52 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the musculoskeletal system RC925-935
spellingShingle	Diseases of the musculoskeletal system RC925-935 AI Aiyegbusi FIO Duru SR Akinbo et al Intrasound therapy in tendon healing: is intensity a factor?
description	AI Aiyegbusi1, FIO Duru1, SR Akinbo2, CC Noronha1, AO Okanlawon11Departments of Anatomy and 2Physiotherapy, College of Medicine, University of Lagos, Lagos, NigeriaObjective: This study investigated the effects of low- and high-intensity intrasound therapy (LITR and HITR, respectively) given once daily and twice daily on the morphology and &shy;oxidative stress in healing tendon tissue following an acute injury.Methods: Eighty-five male rats, randomized into six groups were further subdivided into groups A, B, and C, except for Group 1 which was subdivided into A and B only. Groups 2&ndash;6 underwent an induced crush injury. The six groups were allocated to: serve as controls (Group 1), receive no treatment (Group 2), HITR twice daily (Group 3), HITR once daily (Group 4), LITR twice daily (Group 5), and LITR once daily (Group 6). Intrasound therapy (ITR) was commenced 24 hours postinjury and was given once daily or twice daily over the first 14 days postinjury. The animals in subgroups A and B were sacrificed on day 15 postinjury, and those in subgroup C were sacrificed on day 31 postinjury. The tendons were excised, and processed for histology and malondialdehyde (MDA) assay.Results: There was no significant difference in the tenocyte population between the HITR- and LITR-treated groups. However, twice-daily treatment in either the low- or high-intensity mode resulted in significant tenocyte proliferation compared with the once-daily treated groups, and also had the highest percentage of tenoblasts compared with the population of tenocytes in the proliferative phase of healing. All treatment protocols marginally lowered the MDA level.Conclusion: The role of IRT in tendon healing is influenced more by the frequency of treatment rather than the intensity of the delivered dosage.Keywords: intrasound therapy, tenoblast, tenocytes, tendon injury, crush injury, oxidative stress, malondialdehyde, tenoblast proliferation.
format	article
author	AI Aiyegbusi FIO Duru SR Akinbo et al
author_facet	AI Aiyegbusi FIO Duru SR Akinbo et al
author_sort	AI Aiyegbusi
title	Intrasound therapy in tendon healing: is intensity a factor?
title_short	Intrasound therapy in tendon healing: is intensity a factor?
title_full	Intrasound therapy in tendon healing: is intensity a factor?
title_fullStr	Intrasound therapy in tendon healing: is intensity a factor?
title_full_unstemmed	Intrasound therapy in tendon healing: is intensity a factor?
title_sort	intrasound therapy in tendon healing: is intensity a factor?
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/e585827ee4dc48ec81e57cc457810feb
work_keys_str_mv	AT aiaiyegbusi intrasoundtherapyintendonhealingisintensityafactor AT fioduru intrasoundtherapyintendonhealingisintensityafactor AT srakinbo intrasoundtherapyintendonhealingisintensityafactor AT etal intrasoundtherapyintendonhealingisintensityafactor
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Intrasound therapy in tendon healing: is intensity a factor?

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