Identifying the neck margin status of ductal adenocarcinoma in the pancreatic head by multiphoton microscopy

Abstract Complete surgical resection is the only option for improving the survival of patients with ductal adenocarcinoma in the pancreatic head. After resection, determining the status of resection margins (RMs) is crucial for deciding on the nature of the follow-up treatment. The purpose of this s...

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Autores principales:	Jian Xu, Youting Chen, Hong Chen, Zhipeng Hong, Zheng Shi, Shuangmu Zhuo, Xiaoqin Zhu, Jianxin Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e586b52760e34e47a275f89eb54f9854
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spelling	oai:doaj.org-article:e586b52760e34e47a275f89eb54f98542021-12-02T12:32:50ZIdentifying the neck margin status of ductal adenocarcinoma in the pancreatic head by multiphoton microscopy10.1038/s41598-017-04771-w2045-2322https://doaj.org/article/e586b52760e34e47a275f89eb54f98542017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04771-whttps://doaj.org/toc/2045-2322Abstract Complete surgical resection is the only option for improving the survival of patients with ductal adenocarcinoma in the pancreatic head. After resection, determining the status of resection margins (RMs) is crucial for deciding on the nature of the follow-up treatment. The purpose of this study was to evaluate whether multiphoton microscopy (MPM) could be considered a reliable tool for determining the status of pancreatic neck margins by identifying tumour cells of ductal adenocarcinoma in these margins in the pancreatic head, and our results were affirmative. In particular, MPM could identify tumour cells in the nerves. It was also found that the quantification of the difference between normal duct cells and tumour cells was possible. In addition, the content of collagen could be quantified and used as a marker for differentiating ductal adenocarcinoma in the pancreatic head from normal pancreatic tissues, eventually leading to the identification of R0 and R1 resections of the pancreatic neck margin. With the development of the clinical applications of the multiphoton endoscope, MPM has the potential to provide in vivo real-time identification of RM status during surgery.Jian XuYouting ChenHong ChenZhipeng HongZheng ShiShuangmu ZhuoXiaoqin ZhuJianxin ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian Xu Youting Chen Hong Chen Zhipeng Hong Zheng Shi Shuangmu Zhuo Xiaoqin Zhu Jianxin Chen Identifying the neck margin status of ductal adenocarcinoma in the pancreatic head by multiphoton microscopy
description	Abstract Complete surgical resection is the only option for improving the survival of patients with ductal adenocarcinoma in the pancreatic head. After resection, determining the status of resection margins (RMs) is crucial for deciding on the nature of the follow-up treatment. The purpose of this study was to evaluate whether multiphoton microscopy (MPM) could be considered a reliable tool for determining the status of pancreatic neck margins by identifying tumour cells of ductal adenocarcinoma in these margins in the pancreatic head, and our results were affirmative. In particular, MPM could identify tumour cells in the nerves. It was also found that the quantification of the difference between normal duct cells and tumour cells was possible. In addition, the content of collagen could be quantified and used as a marker for differentiating ductal adenocarcinoma in the pancreatic head from normal pancreatic tissues, eventually leading to the identification of R0 and R1 resections of the pancreatic neck margin. With the development of the clinical applications of the multiphoton endoscope, MPM has the potential to provide in vivo real-time identification of RM status during surgery.
format	article
author	Jian Xu Youting Chen Hong Chen Zhipeng Hong Zheng Shi Shuangmu Zhuo Xiaoqin Zhu Jianxin Chen
author_facet	Jian Xu Youting Chen Hong Chen Zhipeng Hong Zheng Shi Shuangmu Zhuo Xiaoqin Zhu Jianxin Chen
author_sort	Jian Xu
title	Identifying the neck margin status of ductal adenocarcinoma in the pancreatic head by multiphoton microscopy
title_short	Identifying the neck margin status of ductal adenocarcinoma in the pancreatic head by multiphoton microscopy
title_full	Identifying the neck margin status of ductal adenocarcinoma in the pancreatic head by multiphoton microscopy
title_fullStr	Identifying the neck margin status of ductal adenocarcinoma in the pancreatic head by multiphoton microscopy
title_full_unstemmed	Identifying the neck margin status of ductal adenocarcinoma in the pancreatic head by multiphoton microscopy
title_sort	identifying the neck margin status of ductal adenocarcinoma in the pancreatic head by multiphoton microscopy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e586b52760e34e47a275f89eb54f9854
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Identifying the neck margin status of ductal adenocarcinoma in the pancreatic head by multiphoton microscopy

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