Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women

Abstract The clinical spectrum of hypertensive disorders of pregnancy (HDP) is determined by the interplay between environmental and genetic factors, most of which remains unknown. ERAP1, ERAP2 and LNPEP genes code for multifunctional aminopeptidases involved with antigen processing and degradation...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Leonardo Capistrano Ferreira, Carlos Eduardo Maia Gomes, Priya Duggal, Ingrid De Paula Holanda, Amanda Samara de Lima, Paulo Ricardo Porfírio do Nascimento, Selma Maria Bezerra Jeronimo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e5887c92a4b743b5af54dbf0efbd2baf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e5887c92a4b743b5af54dbf0efbd2baf
record_format	dspace
spelling	oai:doaj.org-article:e5887c92a4b743b5af54dbf0efbd2baf2021-12-02T17:04:35ZGenetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women10.1038/s41598-021-86240-z2045-2322https://doaj.org/article/e5887c92a4b743b5af54dbf0efbd2baf2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86240-zhttps://doaj.org/toc/2045-2322Abstract The clinical spectrum of hypertensive disorders of pregnancy (HDP) is determined by the interplay between environmental and genetic factors, most of which remains unknown. ERAP1, ERAP2 and LNPEP genes code for multifunctional aminopeptidases involved with antigen processing and degradation of small peptides such as angiotensin II (Ang II), vasopressin and oxytocin. We aimed to test for associations between genetic variants in aminopeptidases and HDP. A total of 1282 pregnant women (normotensive controls, n = 693; preeclampsia, n = 342; chronic hypertension with superimposed preeclampsia, n = 61; eclampsia, n = 74; and HELLP syndrome, n = 112) were genotyped for variants in LNPEP (rs27300, rs38034, rs2303138), ERAP1 (rs27044, rs30187) and ERAP2 (rs2549796 rs2927609 rs11135484). We also evaluated the effect of ERAP1 rs30187 on plasma Ang II levels in an additional cohort of 65 pregnant women. The genotype C/C, in ERAP1 rs30187 variant (c.1583 T > C, p.Lys528Arg), was associated with increased risk of eclampsia (OR = 1.85, p = 0.019) whereas ERAP2 haplotype rs2549796(C)–rs2927609(C)–rs11135484(G) was associated with preeclampsia (OR = 1.96, corrected p-value = 0.01). Ang II plasma levels did not differ across rs30187 genotypic groups (p = 0.895). In conclusion, ERAP1 gene is associated with eclampsia whereas ERAP2 is associated with preeclampsia, although the mechanism by which genetic variants in ERAPs influence the risk of preeclampsia and eclampsia remain to be elucidated.Leonardo Capistrano FerreiraCarlos Eduardo Maia GomesPriya DuggalIngrid De Paula HolandaAmanda Samara de LimaPaulo Ricardo Porfírio do NascimentoSelma Maria Bezerra JeronimoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leonardo Capistrano Ferreira Carlos Eduardo Maia Gomes Priya Duggal Ingrid De Paula Holanda Amanda Samara de Lima Paulo Ricardo Porfírio do Nascimento Selma Maria Bezerra Jeronimo Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women
description	Abstract The clinical spectrum of hypertensive disorders of pregnancy (HDP) is determined by the interplay between environmental and genetic factors, most of which remains unknown. ERAP1, ERAP2 and LNPEP genes code for multifunctional aminopeptidases involved with antigen processing and degradation of small peptides such as angiotensin II (Ang II), vasopressin and oxytocin. We aimed to test for associations between genetic variants in aminopeptidases and HDP. A total of 1282 pregnant women (normotensive controls, n = 693; preeclampsia, n = 342; chronic hypertension with superimposed preeclampsia, n = 61; eclampsia, n = 74; and HELLP syndrome, n = 112) were genotyped for variants in LNPEP (rs27300, rs38034, rs2303138), ERAP1 (rs27044, rs30187) and ERAP2 (rs2549796 rs2927609 rs11135484). We also evaluated the effect of ERAP1 rs30187 on plasma Ang II levels in an additional cohort of 65 pregnant women. The genotype C/C, in ERAP1 rs30187 variant (c.1583 T > C, p.Lys528Arg), was associated with increased risk of eclampsia (OR = 1.85, p = 0.019) whereas ERAP2 haplotype rs2549796(C)–rs2927609(C)–rs11135484(G) was associated with preeclampsia (OR = 1.96, corrected p-value = 0.01). Ang II plasma levels did not differ across rs30187 genotypic groups (p = 0.895). In conclusion, ERAP1 gene is associated with eclampsia whereas ERAP2 is associated with preeclampsia, although the mechanism by which genetic variants in ERAPs influence the risk of preeclampsia and eclampsia remain to be elucidated.
format	article
author	Leonardo Capistrano Ferreira Carlos Eduardo Maia Gomes Priya Duggal Ingrid De Paula Holanda Amanda Samara de Lima Paulo Ricardo Porfírio do Nascimento Selma Maria Bezerra Jeronimo
author_facet	Leonardo Capistrano Ferreira Carlos Eduardo Maia Gomes Priya Duggal Ingrid De Paula Holanda Amanda Samara de Lima Paulo Ricardo Porfírio do Nascimento Selma Maria Bezerra Jeronimo
author_sort	Leonardo Capistrano Ferreira
title	Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women
title_short	Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women
title_full	Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women
title_fullStr	Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women
title_full_unstemmed	Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women
title_sort	genetic association of erap1 and erap2 with eclampsia and preeclampsia in northeastern brazilian women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e5887c92a4b743b5af54dbf0efbd2baf
work_keys_str_mv	AT leonardocapistranoferreira geneticassociationoferap1anderap2witheclampsiaandpreeclampsiainnortheasternbrazilianwomen AT carloseduardomaiagomes geneticassociationoferap1anderap2witheclampsiaandpreeclampsiainnortheasternbrazilianwomen AT priyaduggal geneticassociationoferap1anderap2witheclampsiaandpreeclampsiainnortheasternbrazilianwomen AT ingriddepaulaholanda geneticassociationoferap1anderap2witheclampsiaandpreeclampsiainnortheasternbrazilianwomen AT amandasamaradelima geneticassociationoferap1anderap2witheclampsiaandpreeclampsiainnortheasternbrazilianwomen AT pauloricardoporfiriodonascimento geneticassociationoferap1anderap2witheclampsiaandpreeclampsiainnortheasternbrazilianwomen AT selmamariabezerrajeronimo geneticassociationoferap1anderap2witheclampsiaandpreeclampsiainnortheasternbrazilianwomen
_version_	1718381881811009536

Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women

Ejemplares similares