Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

Pancreatic beta-cell glucose metabolism is coupled to insulin secretion. Here the authors set out to characterize changes in beta-cell metabolism in hyperglycemia which may contribute to insufficient insulin secretion in type 2 diabetes and, using a multi-omics approach, find that mitochondrial meta...

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Autores principales:	Elizabeth Haythorne, Maria Rohm, Martijn van de Bunt, Melissa F. Brereton, Andrei I. Tarasov, Thomas S. Blacker, Gregor Sachse, Mariana Silva dos Santos, Raul Terron Exposito, Simon Davis, Otto Baba, Roman Fischer, Michael R. Duchen, Patrik Rorsman, James I. MacRae, Frances M. Ashcroft
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e58a88780c484df287e145eadffc1041
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spelling	oai:doaj.org-article:e58a88780c484df287e145eadffc10412021-12-02T17:01:28ZDiabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells10.1038/s41467-019-10189-x2041-1723https://doaj.org/article/e58a88780c484df287e145eadffc10412019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10189-xhttps://doaj.org/toc/2041-1723Pancreatic beta-cell glucose metabolism is coupled to insulin secretion. Here the authors set out to characterize changes in beta-cell metabolism in hyperglycemia which may contribute to insufficient insulin secretion in type 2 diabetes and, using a multi-omics approach, find that mitochondrial metabolism is perturbed.Elizabeth HaythorneMaria RohmMartijn van de BuntMelissa F. BreretonAndrei I. TarasovThomas S. BlackerGregor SachseMariana Silva dos SantosRaul Terron ExpositoSimon DavisOtto BabaRoman FischerMichael R. DuchenPatrik RorsmanJames I. MacRaeFrances M. AshcroftNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elizabeth Haythorne Maria Rohm Martijn van de Bunt Melissa F. Brereton Andrei I. Tarasov Thomas S. Blacker Gregor Sachse Mariana Silva dos Santos Raul Terron Exposito Simon Davis Otto Baba Roman Fischer Michael R. Duchen Patrik Rorsman James I. MacRae Frances M. Ashcroft Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
description	Pancreatic beta-cell glucose metabolism is coupled to insulin secretion. Here the authors set out to characterize changes in beta-cell metabolism in hyperglycemia which may contribute to insufficient insulin secretion in type 2 diabetes and, using a multi-omics approach, find that mitochondrial metabolism is perturbed.
format	article
author	Elizabeth Haythorne Maria Rohm Martijn van de Bunt Melissa F. Brereton Andrei I. Tarasov Thomas S. Blacker Gregor Sachse Mariana Silva dos Santos Raul Terron Exposito Simon Davis Otto Baba Roman Fischer Michael R. Duchen Patrik Rorsman James I. MacRae Frances M. Ashcroft
author_facet	Elizabeth Haythorne Maria Rohm Martijn van de Bunt Melissa F. Brereton Andrei I. Tarasov Thomas S. Blacker Gregor Sachse Mariana Silva dos Santos Raul Terron Exposito Simon Davis Otto Baba Roman Fischer Michael R. Duchen Patrik Rorsman James I. MacRae Frances M. Ashcroft
author_sort	Elizabeth Haythorne
title	Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
title_short	Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
title_full	Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
title_fullStr	Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
title_full_unstemmed	Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
title_sort	diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e58a88780c484df287e145eadffc1041
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Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

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