Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis

Human parechovirus 3 (HPeV3) can cause severe central nervous system infections and is a major cause of neonatal sepsis. Here the authors determine the structure of HPeV3 that provides a high-resolution view of the capsid’s organization and shows multiple interactions of the RNA genome with coat pro...

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Autores principales:	Shabih Shakeel, Brenda M. Westerhuis, Ausra Domanska, Roman I. Koning, Rishi Matadeen, Abraham J. Koster, Arjen Q. Bakker, Tim Beaumont, Katja C. Wolthers, Sarah J. Butcher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e58aa9263cc74ca2b1ca9f27740a4a8d
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spelling	oai:doaj.org-article:e58aa9263cc74ca2b1ca9f27740a4a8d2021-12-02T16:57:49ZMultiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis10.1038/ncomms113872041-1723https://doaj.org/article/e58aa9263cc74ca2b1ca9f27740a4a8d2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms11387https://doaj.org/toc/2041-1723Human parechovirus 3 (HPeV3) can cause severe central nervous system infections and is a major cause of neonatal sepsis. Here the authors determine the structure of HPeV3 that provides a high-resolution view of the capsid’s organization and shows multiple interactions of the RNA genome with coat proteins.Shabih ShakeelBrenda M. WesterhuisAusra DomanskaRoman I. KoningRishi MatadeenAbraham J. KosterArjen Q. BakkerTim BeaumontKatja C. WolthersSarah J. ButcherNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shabih Shakeel Brenda M. Westerhuis Ausra Domanska Roman I. Koning Rishi Matadeen Abraham J. Koster Arjen Q. Bakker Tim Beaumont Katja C. Wolthers Sarah J. Butcher Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis
description	Human parechovirus 3 (HPeV3) can cause severe central nervous system infections and is a major cause of neonatal sepsis. Here the authors determine the structure of HPeV3 that provides a high-resolution view of the capsid’s organization and shows multiple interactions of the RNA genome with coat proteins.
format	article
author	Shabih Shakeel Brenda M. Westerhuis Ausra Domanska Roman I. Koning Rishi Matadeen Abraham J. Koster Arjen Q. Bakker Tim Beaumont Katja C. Wolthers Sarah J. Butcher
author_facet	Shabih Shakeel Brenda M. Westerhuis Ausra Domanska Roman I. Koning Rishi Matadeen Abraham J. Koster Arjen Q. Bakker Tim Beaumont Katja C. Wolthers Sarah J. Butcher
author_sort	Shabih Shakeel
title	Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis
title_short	Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis
title_full	Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis
title_fullStr	Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis
title_full_unstemmed	Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis
title_sort	multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e58aa9263cc74ca2b1ca9f27740a4a8d
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Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis

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