Environmental Risk Factors for Talaromycosis Hospitalizations of HIV-Infected Patients in Guangzhou, China: Case Crossover Study

Talaromycosis is a fatal opportunistic infection prevalent in human immunodeficiency virus (HIV)-infected patients, previous studies suggest environmental humidity is associated with monthly talaromycosis hospitalizations of HIV-infected patients, but the acute risk factor remains uncertain. In this...

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Autores principales:	Yaping Wang, Kai Deng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	talaromycosis temperature humidity SO2 HIV Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e5910ec9386a476dbb5aa7f32b1dceba
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spelling	oai:doaj.org-article:e5910ec9386a476dbb5aa7f32b1dceba2021-11-22T05:28:52ZEnvironmental Risk Factors for Talaromycosis Hospitalizations of HIV-Infected Patients in Guangzhou, China: Case Crossover Study2296-858X10.3389/fmed.2021.731188https://doaj.org/article/e5910ec9386a476dbb5aa7f32b1dceba2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.731188/fullhttps://doaj.org/toc/2296-858XTalaromycosis is a fatal opportunistic infection prevalent in human immunodeficiency virus (HIV)-infected patients, previous studies suggest environmental humidity is associated with monthly talaromycosis hospitalizations of HIV-infected patients, but the acute risk factor remains uncertain. In this study, we evaluated the associations between talaromycosis hospitalizations of HIV-infected patients (n = 919) and environmental factors including meteorological variables and air pollutants at the event day (assumed “lag 0” since the exact infection date is hard to ascertain) and 1–7 days prior to event day (lag 1–lag 7) in conditional logistics regression models based on a case crossover design. We found that an interquartile range (IQR) increase in temperature at lag 0–lag 7 (odds ratio [OR] [95% CI] ranged from 1.748 [1.345–2.273] to 2.184 [1.672–2.854]), and an IQR increase in humidity at lag 0 (OR [95% CI] = 1.192 [1.052–1.350]), and lag 1 (OR [95% CI] = 1.199 [1.056–1.361]) were significantly associated with talaromycosis hospitalizations of HIV-infected patients. Besides, temperature was also a common predictor for talaromycosis in patients with co-infections including candidiasis (n = 386), Pneumocystis pneumonia (n = 183), pulmonary tuberculosis (n = 141), and chronic hepatitis (n = 158), while humidity was a specific risk factor for talaromycosis in patients with candidiasis, and an air pollutant, SO2, was a specific risk factor for talaromycosis in patients with Pneumocystis pneumonia. In an age stratified evaluation (cutoff = 50 years old), temperature was the only variable positively associated with talaromycosis in both younger and older patients. These findings broaden our understanding of the epidemiology and pathogenesis of talaromycosis in HIV-infected patients.Yaping WangKai DengFrontiers Media S.A.articletalaromycosistemperaturehumiditySO2HIVMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	talaromycosis temperature humidity SO2 HIV Medicine (General) R5-920
spellingShingle	talaromycosis temperature humidity SO2 HIV Medicine (General) R5-920 Yaping Wang Kai Deng Environmental Risk Factors for Talaromycosis Hospitalizations of HIV-Infected Patients in Guangzhou, China: Case Crossover Study
description	Talaromycosis is a fatal opportunistic infection prevalent in human immunodeficiency virus (HIV)-infected patients, previous studies suggest environmental humidity is associated with monthly talaromycosis hospitalizations of HIV-infected patients, but the acute risk factor remains uncertain. In this study, we evaluated the associations between talaromycosis hospitalizations of HIV-infected patients (n = 919) and environmental factors including meteorological variables and air pollutants at the event day (assumed “lag 0” since the exact infection date is hard to ascertain) and 1–7 days prior to event day (lag 1–lag 7) in conditional logistics regression models based on a case crossover design. We found that an interquartile range (IQR) increase in temperature at lag 0–lag 7 (odds ratio [OR] [95% CI] ranged from 1.748 [1.345–2.273] to 2.184 [1.672–2.854]), and an IQR increase in humidity at lag 0 (OR [95% CI] = 1.192 [1.052–1.350]), and lag 1 (OR [95% CI] = 1.199 [1.056–1.361]) were significantly associated with talaromycosis hospitalizations of HIV-infected patients. Besides, temperature was also a common predictor for talaromycosis in patients with co-infections including candidiasis (n = 386), Pneumocystis pneumonia (n = 183), pulmonary tuberculosis (n = 141), and chronic hepatitis (n = 158), while humidity was a specific risk factor for talaromycosis in patients with candidiasis, and an air pollutant, SO2, was a specific risk factor for talaromycosis in patients with Pneumocystis pneumonia. In an age stratified evaluation (cutoff = 50 years old), temperature was the only variable positively associated with talaromycosis in both younger and older patients. These findings broaden our understanding of the epidemiology and pathogenesis of talaromycosis in HIV-infected patients.
format	article
author	Yaping Wang Kai Deng
author_facet	Yaping Wang Kai Deng
author_sort	Yaping Wang
title	Environmental Risk Factors for Talaromycosis Hospitalizations of HIV-Infected Patients in Guangzhou, China: Case Crossover Study
title_short	Environmental Risk Factors for Talaromycosis Hospitalizations of HIV-Infected Patients in Guangzhou, China: Case Crossover Study
title_full	Environmental Risk Factors for Talaromycosis Hospitalizations of HIV-Infected Patients in Guangzhou, China: Case Crossover Study
title_fullStr	Environmental Risk Factors for Talaromycosis Hospitalizations of HIV-Infected Patients in Guangzhou, China: Case Crossover Study
title_full_unstemmed	Environmental Risk Factors for Talaromycosis Hospitalizations of HIV-Infected Patients in Guangzhou, China: Case Crossover Study
title_sort	environmental risk factors for talaromycosis hospitalizations of hiv-infected patients in guangzhou, china: case crossover study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e5910ec9386a476dbb5aa7f32b1dceba
work_keys_str_mv	AT yapingwang environmentalriskfactorsfortalaromycosishospitalizationsofhivinfectedpatientsinguangzhouchinacasecrossoverstudy AT kaideng environmentalriskfactorsfortalaromycosishospitalizationsofhivinfectedpatientsinguangzhouchinacasecrossoverstudy
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Environmental Risk Factors for Talaromycosis Hospitalizations of HIV-Infected Patients in Guangzhou, China: Case Crossover Study

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