ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes

ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes

Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) suffer from limited maturation. Here the authors identify ERRγ agonist as a factor that enhances cardiac morphological, metabolic, contractile and electrical maturation of hiPSC-derived CMs with T-tubule formation.

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Autores principales: Kenji Miki, Kohei Deguchi, Misato Nakanishi-Koakutsu, Antonio Lucena-Cacace, Shigeru Kondo, Yuya Fujiwara, Takeshi Hatani, Masako Sasaki, Yuki Naka, Chikako Okubo, Megumi Narita, Ikue Takei, Stephanie C. Napier, Tsukasa Sugo, Sachiko Imaichi, Taku Monjo, Tatsuya Ando, Norihisa Tamura, Kenichi Imahashi, Tomoyuki Nishimoto, Yoshinori Yoshida
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e591e23480c3403b95a1cc6ecca9b455
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spelling oai:doaj.org-article:e591e23480c3403b95a1cc6ecca9b4552021-12-02T17:12:24ZERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes10.1038/s41467-021-23816-32041-1723https://doaj.org/article/e591e23480c3403b95a1cc6ecca9b4552021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23816-3https://doaj.org/toc/2041-1723Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) suffer from limited maturation. Here the authors identify ERRγ agonist as a factor that enhances cardiac morphological, metabolic, contractile and electrical maturation of hiPSC-derived CMs with T-tubule formation.Kenji MikiKohei DeguchiMisato Nakanishi-KoakutsuAntonio Lucena-CacaceShigeru KondoYuya FujiwaraTakeshi HataniMasako SasakiYuki NakaChikako OkuboMegumi NaritaIkue TakeiStephanie C. NapierTsukasa SugoSachiko ImaichiTaku MonjoTatsuya AndoNorihisa TamuraKenichi ImahashiTomoyuki NishimotoYoshinori YoshidaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kenji Miki
Kohei Deguchi
Misato Nakanishi-Koakutsu
Antonio Lucena-Cacace
Shigeru Kondo
Yuya Fujiwara
Takeshi Hatani
Masako Sasaki
Yuki Naka
Chikako Okubo
Megumi Narita
Ikue Takei
Stephanie C. Napier
Tsukasa Sugo
Sachiko Imaichi
Taku Monjo
Tatsuya Ando
Norihisa Tamura
Kenichi Imahashi
Tomoyuki Nishimoto
Yoshinori Yoshida
ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
description Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) suffer from limited maturation. Here the authors identify ERRγ agonist as a factor that enhances cardiac morphological, metabolic, contractile and electrical maturation of hiPSC-derived CMs with T-tubule formation.
format article
author Kenji Miki
Kohei Deguchi
Misato Nakanishi-Koakutsu
Antonio Lucena-Cacace
Shigeru Kondo
Yuya Fujiwara
Takeshi Hatani
Masako Sasaki
Yuki Naka
Chikako Okubo
Megumi Narita
Ikue Takei
Stephanie C. Napier
Tsukasa Sugo
Sachiko Imaichi
Taku Monjo
Tatsuya Ando
Norihisa Tamura
Kenichi Imahashi
Tomoyuki Nishimoto
Yoshinori Yoshida
author_facet Kenji Miki
Kohei Deguchi
Misato Nakanishi-Koakutsu
Antonio Lucena-Cacace
Shigeru Kondo
Yuya Fujiwara
Takeshi Hatani
Masako Sasaki
Yuki Naka
Chikako Okubo
Megumi Narita
Ikue Takei
Stephanie C. Napier
Tsukasa Sugo
Sachiko Imaichi
Taku Monjo
Tatsuya Ando
Norihisa Tamura
Kenichi Imahashi
Tomoyuki Nishimoto
Yoshinori Yoshida
author_sort Kenji Miki
title ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
title_short ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
title_full ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
title_fullStr ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
title_full_unstemmed ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
title_sort errγ enhances cardiac maturation with t-tubule formation in human ipsc-derived cardiomyocytes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e591e23480c3403b95a1cc6ecca9b455
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