Maternal pre-pregnancy weight and early life lower respiratory tract infections in a low-income urban minority birth cohort

Abstract The prevalence of maternal obesity has increased dramatically with adverse consequences on infant health. Prior studies have reported associations between maternal obesity and childhood wheeze, asthma as well as lower respiratory tract infections (LRTI). However, studies examining the assoc...

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Autores principales:	Maria J. Gutierrez, Gustavo Nino, Xiumei Hong, Xiaobin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e5925ee3ab0745c085595b4f1554900b
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spelling	oai:doaj.org-article:e5925ee3ab0745c085595b4f1554900b2021-12-02T14:41:52ZMaternal pre-pregnancy weight and early life lower respiratory tract infections in a low-income urban minority birth cohort10.1038/s41598-021-88360-y2045-2322https://doaj.org/article/e5925ee3ab0745c085595b4f1554900b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88360-yhttps://doaj.org/toc/2045-2322Abstract The prevalence of maternal obesity has increased dramatically with adverse consequences on infant health. Prior studies have reported associations between maternal obesity and childhood wheeze, asthma as well as lower respiratory tract infections (LRTI). However, studies examining the association of obesity with early-life LRTIs in low-income urban minority populations are still lacking. This is a critical gap because both obesity and infant respiratory morbidity are more prevalent and severe in these communities. We examined mother‐child dyads from the Boston Birth Cohort (BBC) to define the longitudinal association of maternal pre‐pregnancy BMI and LRTI in infancy, defined as the presence of bronchiolitis, bronchitis, or pneumonia during the first year of life (< 12 months of age). A total of 2,790 mother‐child dyads were included in our analyses. Infants born to pre-pregnancy obese mothers (n = 688, 25%) had 1.43 increased odds (adjOR = 1.43, 95% CI 1.08–1.88, p = 0.012) of developing LRTI during the first year of life when compared with newborns born to normal-weight mothers after adjusting by relevant LRTI risk factors. Notably, infants born to overweight mothers (n = 808, 29%) followed a similar trend (adjOR = 1.31, 95% CI 1.00–1.72, p = 0.048). Our study demonstrated that maternal pre-pregnancy obesity is an independent risk factor for the development of LRTI during infancy in a low-income urban minority birth cohort.Maria J. GutierrezGustavo NinoXiumei HongXiaobin WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria J. Gutierrez Gustavo Nino Xiumei Hong Xiaobin Wang Maternal pre-pregnancy weight and early life lower respiratory tract infections in a low-income urban minority birth cohort
description	Abstract The prevalence of maternal obesity has increased dramatically with adverse consequences on infant health. Prior studies have reported associations between maternal obesity and childhood wheeze, asthma as well as lower respiratory tract infections (LRTI). However, studies examining the association of obesity with early-life LRTIs in low-income urban minority populations are still lacking. This is a critical gap because both obesity and infant respiratory morbidity are more prevalent and severe in these communities. We examined mother‐child dyads from the Boston Birth Cohort (BBC) to define the longitudinal association of maternal pre‐pregnancy BMI and LRTI in infancy, defined as the presence of bronchiolitis, bronchitis, or pneumonia during the first year of life (< 12 months of age). A total of 2,790 mother‐child dyads were included in our analyses. Infants born to pre-pregnancy obese mothers (n = 688, 25%) had 1.43 increased odds (adjOR = 1.43, 95% CI 1.08–1.88, p = 0.012) of developing LRTI during the first year of life when compared with newborns born to normal-weight mothers after adjusting by relevant LRTI risk factors. Notably, infants born to overweight mothers (n = 808, 29%) followed a similar trend (adjOR = 1.31, 95% CI 1.00–1.72, p = 0.048). Our study demonstrated that maternal pre-pregnancy obesity is an independent risk factor for the development of LRTI during infancy in a low-income urban minority birth cohort.
format	article
author	Maria J. Gutierrez Gustavo Nino Xiumei Hong Xiaobin Wang
author_facet	Maria J. Gutierrez Gustavo Nino Xiumei Hong Xiaobin Wang
author_sort	Maria J. Gutierrez
title	Maternal pre-pregnancy weight and early life lower respiratory tract infections in a low-income urban minority birth cohort
title_short	Maternal pre-pregnancy weight and early life lower respiratory tract infections in a low-income urban minority birth cohort
title_full	Maternal pre-pregnancy weight and early life lower respiratory tract infections in a low-income urban minority birth cohort
title_fullStr	Maternal pre-pregnancy weight and early life lower respiratory tract infections in a low-income urban minority birth cohort
title_full_unstemmed	Maternal pre-pregnancy weight and early life lower respiratory tract infections in a low-income urban minority birth cohort
title_sort	maternal pre-pregnancy weight and early life lower respiratory tract infections in a low-income urban minority birth cohort
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e5925ee3ab0745c085595b4f1554900b
work_keys_str_mv	AT mariajgutierrez maternalprepregnancyweightandearlylifelowerrespiratorytractinfectionsinalowincomeurbanminoritybirthcohort AT gustavonino maternalprepregnancyweightandearlylifelowerrespiratorytractinfectionsinalowincomeurbanminoritybirthcohort AT xiumeihong maternalprepregnancyweightandearlylifelowerrespiratorytractinfectionsinalowincomeurbanminoritybirthcohort AT xiaobinwang maternalprepregnancyweightandearlylifelowerrespiratorytractinfectionsinalowincomeurbanminoritybirthcohort
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Maternal pre-pregnancy weight and early life lower respiratory tract infections in a low-income urban minority birth cohort

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