Hydroxychloroquine in COVID-19: The Study Points to Premature Decisions on Efficacy While Bells Ringing for Safety

Sitaram Khadka,1 Dhan Bahadur Shrestha,2 Pravash Budhathoki,3 Era Rawal4 1Department of Pharmacy, Shree Birendra Hospital; Nepalese Army Institute of Health Sciences, Kathmandu 44600, Nepal; 2Department of Emergency Medicine and General Practice, Mangalbare Hospital, Morang 56600, Nepal; 3Department...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Khadka S, Shrestha DB, Budhathoki P, Rawal E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cardiac arrythmia covid-19 drug repositioning hydroxychloroquine severe acute respiratory syndrome coronavirus-2 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e5946be682cf4c429c766ca76940e0f0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e5946be682cf4c429c766ca76940e0f0
record_format	dspace
spelling	oai:doaj.org-article:e5946be682cf4c429c766ca76940e0f02021-12-02T10:09:42ZHydroxychloroquine in COVID-19: The Study Points to Premature Decisions on Efficacy While Bells Ringing for Safety1179-1438https://doaj.org/article/e5946be682cf4c429c766ca76940e0f02020-08-01T00:00:00Zhttps://www.dovepress.com/hydroxychloroquine-in-covid-19-the-study-points-to-premature-decisions-peer-reviewed-article-CPAAhttps://doaj.org/toc/1179-1438Sitaram Khadka,1 Dhan Bahadur Shrestha,2 Pravash Budhathoki,3 Era Rawal4 1Department of Pharmacy, Shree Birendra Hospital; Nepalese Army Institute of Health Sciences, Kathmandu 44600, Nepal; 2Department of Emergency Medicine and General Practice, Mangalbare Hospital, Morang 56600, Nepal; 3Department of Emergency Medicine and General Practice, Dr Iwamura Memorial Hospital, Bhaktapur 44800, Nepal; 4Department of Emergency Medicine and General Practice, Kathmandu Medical College, Kathmandu 44600, NepalCorrespondence: Sitaram KhadkaDepartment of Pharmacy, Shree Birendra Hospital; Nepalese Army Institute of Health Sciences, Kathmandu 44600, NepalTel +00977-9851077589Email sitaram.khadka@naihs.edu.npAbstract: Coronavirus disease (COVID-19) pandemic has been a global disease burden. It has affected more than sixteen million people in the world within seven months of its first outbreak in Wuhan. Different treatment modalities, therapeutic and prophylactic agents for its therapy are underway. Until the proven therapy gets available, repurposing of drugs is a better way out. Hydroxychloroquine (HCQ) has been a potential recourse of treatment in this regard for COVID-19 management. As different episodes of cardiac adverse events of HCQ are reported, safety concerns are now a prime objective. The risk-benefit analysis is mandatory to address rational drug therapy even in such a global health crisis. In this article, we want to evaluate the safety and efficacy of HCQ in COVID-19 management.Keywords: cardiac arrhythmia, COVID-19, drug repositioning, hydroxychloroquine, severe acute respiratory syndrome coronavirus-2Khadka SShrestha DBBudhathoki PRawal EDove Medical Pressarticlecardiac arrythmiacovid-19drug repositioninghydroxychloroquinesevere acute respiratory syndrome coronavirus-2Therapeutics. PharmacologyRM1-950ENClinical Pharmacology: Advances and Applications, Vol Volume 12, Pp 115-121 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiac arrythmia covid-19 drug repositioning hydroxychloroquine severe acute respiratory syndrome coronavirus-2 Therapeutics. Pharmacology RM1-950
spellingShingle	cardiac arrythmia covid-19 drug repositioning hydroxychloroquine severe acute respiratory syndrome coronavirus-2 Therapeutics. Pharmacology RM1-950 Khadka S Shrestha DB Budhathoki P Rawal E Hydroxychloroquine in COVID-19: The Study Points to Premature Decisions on Efficacy While Bells Ringing for Safety
description	Sitaram Khadka,1 Dhan Bahadur Shrestha,2 Pravash Budhathoki,3 Era Rawal4 1Department of Pharmacy, Shree Birendra Hospital; Nepalese Army Institute of Health Sciences, Kathmandu 44600, Nepal; 2Department of Emergency Medicine and General Practice, Mangalbare Hospital, Morang 56600, Nepal; 3Department of Emergency Medicine and General Practice, Dr Iwamura Memorial Hospital, Bhaktapur 44800, Nepal; 4Department of Emergency Medicine and General Practice, Kathmandu Medical College, Kathmandu 44600, NepalCorrespondence: Sitaram KhadkaDepartment of Pharmacy, Shree Birendra Hospital; Nepalese Army Institute of Health Sciences, Kathmandu 44600, NepalTel +00977-9851077589Email sitaram.khadka@naihs.edu.npAbstract: Coronavirus disease (COVID-19) pandemic has been a global disease burden. It has affected more than sixteen million people in the world within seven months of its first outbreak in Wuhan. Different treatment modalities, therapeutic and prophylactic agents for its therapy are underway. Until the proven therapy gets available, repurposing of drugs is a better way out. Hydroxychloroquine (HCQ) has been a potential recourse of treatment in this regard for COVID-19 management. As different episodes of cardiac adverse events of HCQ are reported, safety concerns are now a prime objective. The risk-benefit analysis is mandatory to address rational drug therapy even in such a global health crisis. In this article, we want to evaluate the safety and efficacy of HCQ in COVID-19 management.Keywords: cardiac arrhythmia, COVID-19, drug repositioning, hydroxychloroquine, severe acute respiratory syndrome coronavirus-2
format	article
author	Khadka S Shrestha DB Budhathoki P Rawal E
author_facet	Khadka S Shrestha DB Budhathoki P Rawal E
author_sort	Khadka S
title	Hydroxychloroquine in COVID-19: The Study Points to Premature Decisions on Efficacy While Bells Ringing for Safety
title_short	Hydroxychloroquine in COVID-19: The Study Points to Premature Decisions on Efficacy While Bells Ringing for Safety
title_full	Hydroxychloroquine in COVID-19: The Study Points to Premature Decisions on Efficacy While Bells Ringing for Safety
title_fullStr	Hydroxychloroquine in COVID-19: The Study Points to Premature Decisions on Efficacy While Bells Ringing for Safety
title_full_unstemmed	Hydroxychloroquine in COVID-19: The Study Points to Premature Decisions on Efficacy While Bells Ringing for Safety
title_sort	hydroxychloroquine in covid-19: the study points to premature decisions on efficacy while bells ringing for safety
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e5946be682cf4c429c766ca76940e0f0
work_keys_str_mv	AT khadkas hydroxychloroquineincovid19thestudypointstoprematuredecisionsonefficacywhilebellsringingforsafety AT shresthadb hydroxychloroquineincovid19thestudypointstoprematuredecisionsonefficacywhilebellsringingforsafety AT budhathokip hydroxychloroquineincovid19thestudypointstoprematuredecisionsonefficacywhilebellsringingforsafety AT rawale hydroxychloroquineincovid19thestudypointstoprematuredecisionsonefficacywhilebellsringingforsafety
_version_	1718397613655457792

Hydroxychloroquine in COVID-19: The Study Points to Premature Decisions on Efficacy While Bells Ringing for Safety

Ejemplares similares