Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling

Endothelial tissues must have intact barrier function, but this may be disrupted during inflammation. Here, the authors show that the mitochondrial protein Mitofusin-2 stabilizes cell–cell adherens junctions in endothelial cells during homeostasis and binds the transcriptional activator β-catenin up...

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Autores principales: Young-Mee Kim, Sarah Krantz, Ankit Jambusaria, Peter T. Toth, Hyung-Geun Moon, Isuru Gunarathna, Gye Young Park, Jalees Rehman
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e5953cf98299418595f144ad5dbc7489
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spelling oai:doaj.org-article:e5953cf98299418595f144ad5dbc74892021-12-02T16:50:26ZMitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling10.1038/s41467-021-23047-62041-1723https://doaj.org/article/e5953cf98299418595f144ad5dbc74892021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23047-6https://doaj.org/toc/2041-1723Endothelial tissues must have intact barrier function, but this may be disrupted during inflammation. Here, the authors show that the mitochondrial protein Mitofusin-2 stabilizes cell–cell adherens junctions in endothelial cells during homeostasis and binds the transcriptional activator β-catenin upon inflammatory stimulation.Young-Mee KimSarah KrantzAnkit JambusariaPeter T. TothHyung-Geun MoonIsuru GunarathnaGye Young ParkJalees RehmanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Young-Mee Kim
Sarah Krantz
Ankit Jambusaria
Peter T. Toth
Hyung-Geun Moon
Isuru Gunarathna
Gye Young Park
Jalees Rehman
Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling
description Endothelial tissues must have intact barrier function, but this may be disrupted during inflammation. Here, the authors show that the mitochondrial protein Mitofusin-2 stabilizes cell–cell adherens junctions in endothelial cells during homeostasis and binds the transcriptional activator β-catenin upon inflammatory stimulation.
format article
author Young-Mee Kim
Sarah Krantz
Ankit Jambusaria
Peter T. Toth
Hyung-Geun Moon
Isuru Gunarathna
Gye Young Park
Jalees Rehman
author_facet Young-Mee Kim
Sarah Krantz
Ankit Jambusaria
Peter T. Toth
Hyung-Geun Moon
Isuru Gunarathna
Gye Young Park
Jalees Rehman
author_sort Young-Mee Kim
title Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling
title_short Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling
title_full Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling
title_fullStr Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling
title_full_unstemmed Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling
title_sort mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e5953cf98299418595f144ad5dbc7489
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