Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling
Endothelial tissues must have intact barrier function, but this may be disrupted during inflammation. Here, the authors show that the mitochondrial protein Mitofusin-2 stabilizes cell–cell adherens junctions in endothelial cells during homeostasis and binds the transcriptional activator β-catenin up...
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Nature Portfolio
2021
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oai:doaj.org-article:e5953cf98299418595f144ad5dbc74892021-12-02T16:50:26ZMitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling10.1038/s41467-021-23047-62041-1723https://doaj.org/article/e5953cf98299418595f144ad5dbc74892021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23047-6https://doaj.org/toc/2041-1723Endothelial tissues must have intact barrier function, but this may be disrupted during inflammation. Here, the authors show that the mitochondrial protein Mitofusin-2 stabilizes cell–cell adherens junctions in endothelial cells during homeostasis and binds the transcriptional activator β-catenin upon inflammatory stimulation.Young-Mee KimSarah KrantzAnkit JambusariaPeter T. TothHyung-Geun MoonIsuru GunarathnaGye Young ParkJalees RehmanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
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Science Q Young-Mee Kim Sarah Krantz Ankit Jambusaria Peter T. Toth Hyung-Geun Moon Isuru Gunarathna Gye Young Park Jalees Rehman Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling |
description |
Endothelial tissues must have intact barrier function, but this may be disrupted during inflammation. Here, the authors show that the mitochondrial protein Mitofusin-2 stabilizes cell–cell adherens junctions in endothelial cells during homeostasis and binds the transcriptional activator β-catenin upon inflammatory stimulation. |
format |
article |
author |
Young-Mee Kim Sarah Krantz Ankit Jambusaria Peter T. Toth Hyung-Geun Moon Isuru Gunarathna Gye Young Park Jalees Rehman |
author_facet |
Young-Mee Kim Sarah Krantz Ankit Jambusaria Peter T. Toth Hyung-Geun Moon Isuru Gunarathna Gye Young Park Jalees Rehman |
author_sort |
Young-Mee Kim |
title |
Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling |
title_short |
Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling |
title_full |
Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling |
title_fullStr |
Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling |
title_full_unstemmed |
Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling |
title_sort |
mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/e5953cf98299418595f144ad5dbc7489 |
work_keys_str_mv |
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