Fabrication of Fresnel plates on optical fibres by FIB milling for optical trapping, manipulation and detection of single cells

Abstract The development of economical optical devices with a reduced footprint foreseeing manipulation, sorting and detection of single cells and other micro particles have been encouraged by cellular biology requirements. Nonetheless, researchers are still ambitious for advances in this field. Thi...

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Autores principales:	Rita S. Rodrigues Ribeiro, Pabitra Dahal, Ariel Guerreiro, Pedro A. S. Jorge, Jaime Viegas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e59e74ff6a1348a781d5a04ece69ec7e
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spelling	oai:doaj.org-article:e59e74ff6a1348a781d5a04ece69ec7e2021-12-02T11:52:16ZFabrication of Fresnel plates on optical fibres by FIB milling for optical trapping, manipulation and detection of single cells10.1038/s41598-017-04490-22045-2322https://doaj.org/article/e59e74ff6a1348a781d5a04ece69ec7e2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04490-2https://doaj.org/toc/2045-2322Abstract The development of economical optical devices with a reduced footprint foreseeing manipulation, sorting and detection of single cells and other micro particles have been encouraged by cellular biology requirements. Nonetheless, researchers are still ambitious for advances in this field. This paper presents Fresnel zone and phase plates fabricated on mode expanded optical fibres for optical trapping. The diffractive structures were fabricated using focused ion beam milling. The zone plates presented in this work have focal distance of ~5 µm, while the focal distance of the phase plates is ~10 µm. The phase plates are implemented in an optical trapping configuration, and 2D manipulation and detection of 8 µm PMMA beads and yeast cells is reported. This enables new applications for optical trapping setups based on diffractive optical elements on optical fibre tips, where feedback systems can be integrated to automatically detect, manipulate and sort cells.Rita S. Rodrigues RibeiroPabitra DahalAriel GuerreiroPedro A. S. JorgeJaime ViegasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rita S. Rodrigues Ribeiro Pabitra Dahal Ariel Guerreiro Pedro A. S. Jorge Jaime Viegas Fabrication of Fresnel plates on optical fibres by FIB milling for optical trapping, manipulation and detection of single cells
description	Abstract The development of economical optical devices with a reduced footprint foreseeing manipulation, sorting and detection of single cells and other micro particles have been encouraged by cellular biology requirements. Nonetheless, researchers are still ambitious for advances in this field. This paper presents Fresnel zone and phase plates fabricated on mode expanded optical fibres for optical trapping. The diffractive structures were fabricated using focused ion beam milling. The zone plates presented in this work have focal distance of ~5 µm, while the focal distance of the phase plates is ~10 µm. The phase plates are implemented in an optical trapping configuration, and 2D manipulation and detection of 8 µm PMMA beads and yeast cells is reported. This enables new applications for optical trapping setups based on diffractive optical elements on optical fibre tips, where feedback systems can be integrated to automatically detect, manipulate and sort cells.
format	article
author	Rita S. Rodrigues Ribeiro Pabitra Dahal Ariel Guerreiro Pedro A. S. Jorge Jaime Viegas
author_facet	Rita S. Rodrigues Ribeiro Pabitra Dahal Ariel Guerreiro Pedro A. S. Jorge Jaime Viegas
author_sort	Rita S. Rodrigues Ribeiro
title	Fabrication of Fresnel plates on optical fibres by FIB milling for optical trapping, manipulation and detection of single cells
title_short	Fabrication of Fresnel plates on optical fibres by FIB milling for optical trapping, manipulation and detection of single cells
title_full	Fabrication of Fresnel plates on optical fibres by FIB milling for optical trapping, manipulation and detection of single cells
title_fullStr	Fabrication of Fresnel plates on optical fibres by FIB milling for optical trapping, manipulation and detection of single cells
title_full_unstemmed	Fabrication of Fresnel plates on optical fibres by FIB milling for optical trapping, manipulation and detection of single cells
title_sort	fabrication of fresnel plates on optical fibres by fib milling for optical trapping, manipulation and detection of single cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e59e74ff6a1348a781d5a04ece69ec7e
work_keys_str_mv	AT ritasrodriguesribeiro fabricationoffresnelplatesonopticalfibresbyfibmillingforopticaltrappingmanipulationanddetectionofsinglecells AT pabitradahal fabricationoffresnelplatesonopticalfibresbyfibmillingforopticaltrappingmanipulationanddetectionofsinglecells AT arielguerreiro fabricationoffresnelplatesonopticalfibresbyfibmillingforopticaltrappingmanipulationanddetectionofsinglecells AT pedroasjorge fabricationoffresnelplatesonopticalfibresbyfibmillingforopticaltrappingmanipulationanddetectionofsinglecells AT jaimeviegas fabricationoffresnelplatesonopticalfibresbyfibmillingforopticaltrappingmanipulationanddetectionofsinglecells
_version_	1718395136968228864

Fabrication of Fresnel plates on optical fibres by FIB milling for optical trapping, manipulation and detection of single cells

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