NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction

The saw-scaled viper venom causes continued tissue damage that may cause death. Here the authors show that the venom attracts neutrophils to the bite site and induces neutrophil extracellular traps that capture venom components causing tissue damage, which can be prevented by enzymatic DNA degradati...

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Autores principales:	Gajanan D. Katkar, Mahalingam S. Sundaram, Somanathapura K. NaveenKumar, Basavarajaiah Swethakumar, Rachana D. Sharma, Manoj Paul, Gopalapura J. Vishalakshi, Sannaningaiah Devaraja, Kesturu S. Girish, Kempaiah Kemparaju
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e5a4eac896c04b2da861157c352e0645
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spelling	oai:doaj.org-article:e5a4eac896c04b2da861157c352e06452021-12-02T15:34:11ZNETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction10.1038/ncomms113612041-1723https://doaj.org/article/e5a4eac896c04b2da861157c352e06452016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11361https://doaj.org/toc/2041-1723The saw-scaled viper venom causes continued tissue damage that may cause death. Here the authors show that the venom attracts neutrophils to the bite site and induces neutrophil extracellular traps that capture venom components causing tissue damage, which can be prevented by enzymatic DNA degradation.Gajanan D. KatkarMahalingam S. SundaramSomanathapura K. NaveenKumarBasavarajaiah SwethakumarRachana D. SharmaManoj PaulGopalapura J. VishalakshiSannaningaiah DevarajaKesturu S. GirishKempaiah KemparajuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gajanan D. Katkar Mahalingam S. Sundaram Somanathapura K. NaveenKumar Basavarajaiah Swethakumar Rachana D. Sharma Manoj Paul Gopalapura J. Vishalakshi Sannaningaiah Devaraja Kesturu S. Girish Kempaiah Kemparaju NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction
description	The saw-scaled viper venom causes continued tissue damage that may cause death. Here the authors show that the venom attracts neutrophils to the bite site and induces neutrophil extracellular traps that capture venom components causing tissue damage, which can be prevented by enzymatic DNA degradation.
format	article
author	Gajanan D. Katkar Mahalingam S. Sundaram Somanathapura K. NaveenKumar Basavarajaiah Swethakumar Rachana D. Sharma Manoj Paul Gopalapura J. Vishalakshi Sannaningaiah Devaraja Kesturu S. Girish Kempaiah Kemparaju
author_facet	Gajanan D. Katkar Mahalingam S. Sundaram Somanathapura K. NaveenKumar Basavarajaiah Swethakumar Rachana D. Sharma Manoj Paul Gopalapura J. Vishalakshi Sannaningaiah Devaraja Kesturu S. Girish Kempaiah Kemparaju
author_sort	Gajanan D. Katkar
title	NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction
title_short	NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction
title_full	NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction
title_fullStr	NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction
title_full_unstemmed	NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction
title_sort	netosis and lack of dnase activity are key factors in echis carinatus venom-induced tissue destruction
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e5a4eac896c04b2da861157c352e0645
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NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction

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