Activity of the adrenocortical system in rats with experimental diabetes

Aim. To study the functional state of the adrenocortical system in experimental animals depending on severity of alloxan diabetes. Materials and methods. Diabetes in rats was induced by administering alloxan tetrahydrate at a dose of 17 mg/100 g b.w. Corticosteroids in plasma,adrenals, and 24-hr u...

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Autores principales:	Olga Pavlovna Cherkasova, Natalya Vladimirovna Kuznetsova, Natalya Alexandrovna Pal'chikova, Vera Georgievna Selyatitskaya
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2011
Materias:	experimental diabetes corticosteroids adrenal glands blood urine Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/e5a531203bbf4405937ebdd748e3a288
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spelling	oai:doaj.org-article:e5a531203bbf4405937ebdd748e3a2882021-11-14T09:00:16ZActivity of the adrenocortical system in rats with experimental diabetes2072-03512072-037810.14341/2072-0351-5632https://doaj.org/article/e5a531203bbf4405937ebdd748e3a2882011-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5632https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To study the functional state of the adrenocortical system in experimental animals depending on severity of alloxan diabetes. Materials and methods. Diabetes in rats was induced by administering alloxan tetrahydrate at a dose of 17 mg/100 g b.w. Corticosteroids in plasma,adrenals, and 24-hr urine were measured by RIA, immunoenzyme assay, and HPLC. Hepatic aminotransferase activities were determined. Results. Durng the first week after induction of diabetes, the animals suffered metabolic disturbances and hypoinsulinemia the severity of which didnot significantly change up to day 30 Activation of adrenal glucocorticoid function (a rise in plasma corticosteron, urine and adrenal corticosteronand progesteron) occurred starting from days 8-9. Enhanced activity of hepatic aminotransferases confirmed physiological significance of elevatedblood corticosteron level. Conclusion. Physiological effects of glucocorticoids in the liver decreased by day 30 of experimental diabetes despite persisting disturbances in carbohydratemetabolism, probably due to reduced synthesis of corticosteron in adrenals and its concentration in blood.Olga Pavlovna CherkasovaNatalya Vladimirovna KuznetsovaNatalya Alexandrovna Pal'chikovaVera Georgievna SelyatitskayaEndocrinology Research Centrearticleexperimental diabetescorticosteroidsadrenal glandsbloodurineNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 14, Iss 2, Pp 37-40 (2011)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	experimental diabetes corticosteroids adrenal glands blood urine Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	experimental diabetes corticosteroids adrenal glands blood urine Nutritional diseases. Deficiency diseases RC620-627 Olga Pavlovna Cherkasova Natalya Vladimirovna Kuznetsova Natalya Alexandrovna Pal'chikova Vera Georgievna Selyatitskaya Activity of the adrenocortical system in rats with experimental diabetes
description	Aim. To study the functional state of the adrenocortical system in experimental animals depending on severity of alloxan diabetes. Materials and methods. Diabetes in rats was induced by administering alloxan tetrahydrate at a dose of 17 mg/100 g b.w. Corticosteroids in plasma,adrenals, and 24-hr urine were measured by RIA, immunoenzyme assay, and HPLC. Hepatic aminotransferase activities were determined. Results. Durng the first week after induction of diabetes, the animals suffered metabolic disturbances and hypoinsulinemia the severity of which didnot significantly change up to day 30 Activation of adrenal glucocorticoid function (a rise in plasma corticosteron, urine and adrenal corticosteronand progesteron) occurred starting from days 8-9. Enhanced activity of hepatic aminotransferases confirmed physiological significance of elevatedblood corticosteron level. Conclusion. Physiological effects of glucocorticoids in the liver decreased by day 30 of experimental diabetes despite persisting disturbances in carbohydratemetabolism, probably due to reduced synthesis of corticosteron in adrenals and its concentration in blood.
format	article
author	Olga Pavlovna Cherkasova Natalya Vladimirovna Kuznetsova Natalya Alexandrovna Pal'chikova Vera Georgievna Selyatitskaya
author_facet	Olga Pavlovna Cherkasova Natalya Vladimirovna Kuznetsova Natalya Alexandrovna Pal'chikova Vera Georgievna Selyatitskaya
author_sort	Olga Pavlovna Cherkasova
title	Activity of the adrenocortical system in rats with experimental diabetes
title_short	Activity of the adrenocortical system in rats with experimental diabetes
title_full	Activity of the adrenocortical system in rats with experimental diabetes
title_fullStr	Activity of the adrenocortical system in rats with experimental diabetes
title_full_unstemmed	Activity of the adrenocortical system in rats with experimental diabetes
title_sort	activity of the adrenocortical system in rats with experimental diabetes
publisher	Endocrinology Research Centre
publishDate	2011
url	https://doaj.org/article/e5a531203bbf4405937ebdd748e3a288
work_keys_str_mv	AT olgapavlovnacherkasova activityoftheadrenocorticalsysteminratswithexperimentaldiabetes AT natalyavladimirovnakuznetsova activityoftheadrenocorticalsysteminratswithexperimentaldiabetes AT natalyaalexandrovnapalchikova activityoftheadrenocorticalsysteminratswithexperimentaldiabetes AT verageorgievnaselyatitskaya activityoftheadrenocorticalsysteminratswithexperimentaldiabetes
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Activity of the adrenocortical system in rats with experimental diabetes

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