Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality

Scorpion venom causes thousands of deaths worldwide. Here the authors show that the envenomation acts via prostaglandin E2 leading to inflammasome activation and lung pathology, counterbalanced by inflammation-limiting LTB4, and that COX inhibitors or exogenous LTB4 rescue the venom-induced mortalit...

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Autores principales:	Karina F. Zoccal, Carlos A. Sorgi, Juliana I. Hori, Francisco W. G. Paula-Silva, Eliane C. Arantes, Carlos H. Serezani, Dario S. Zamboni, Lúcia H. Faccioli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e5a78ff56bba431db5aa20e5f7cb0854
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spelling	oai:doaj.org-article:e5a78ff56bba431db5aa20e5f7cb08542021-12-02T15:34:33ZOpposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality10.1038/ncomms107602041-1723https://doaj.org/article/e5a78ff56bba431db5aa20e5f7cb08542016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10760https://doaj.org/toc/2041-1723Scorpion venom causes thousands of deaths worldwide. Here the authors show that the envenomation acts via prostaglandin E2 leading to inflammasome activation and lung pathology, counterbalanced by inflammation-limiting LTB4, and that COX inhibitors or exogenous LTB4 rescue the venom-induced mortality in mice.Karina F. ZoccalCarlos A. SorgiJuliana I. HoriFrancisco W. G. Paula-SilvaEliane C. ArantesCarlos H. SerezaniDario S. ZamboniLúcia H. FaccioliNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karina F. Zoccal Carlos A. Sorgi Juliana I. Hori Francisco W. G. Paula-Silva Eliane C. Arantes Carlos H. Serezani Dario S. Zamboni Lúcia H. Faccioli Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality
description	Scorpion venom causes thousands of deaths worldwide. Here the authors show that the envenomation acts via prostaglandin E2 leading to inflammasome activation and lung pathology, counterbalanced by inflammation-limiting LTB4, and that COX inhibitors or exogenous LTB4 rescue the venom-induced mortality in mice.
format	article
author	Karina F. Zoccal Carlos A. Sorgi Juliana I. Hori Francisco W. G. Paula-Silva Eliane C. Arantes Carlos H. Serezani Dario S. Zamboni Lúcia H. Faccioli
author_facet	Karina F. Zoccal Carlos A. Sorgi Juliana I. Hori Francisco W. G. Paula-Silva Eliane C. Arantes Carlos H. Serezani Dario S. Zamboni Lúcia H. Faccioli
author_sort	Karina F. Zoccal
title	Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality
title_short	Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality
title_full	Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality
title_fullStr	Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality
title_full_unstemmed	Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality
title_sort	opposing roles of ltb4 and pge2 in regulating the inflammasome-dependent scorpion venom-induced mortality
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e5a78ff56bba431db5aa20e5f7cb0854
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Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality

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