Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality

Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality

Scorpion venom causes thousands of deaths worldwide. Here the authors show that the envenomation acts via prostaglandin E2 leading to inflammasome activation and lung pathology, counterbalanced by inflammation-limiting LTB4, and that COX inhibitors or exogenous LTB4 rescue the venom-induced mortalit...

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Autores principales: Karina F. Zoccal, Carlos A. Sorgi, Juliana I. Hori, Francisco W. G. Paula-Silva, Eliane C. Arantes, Carlos H. Serezani, Dario S. Zamboni, Lúcia H. Faccioli
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/e5a78ff56bba431db5aa20e5f7cb0854
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