Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer

Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer

Structural variations in gastric cancer impact progression. Here, the authors perform whole-genome sequencing on 168 gastric cancer patients and identified tandem-duplications of super-enhancer ZFP36L2 in 10% of gastric cancer, and mutational signatures in tumors with cadherin 1 mutations that assoc...

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Autores principales: Rui Xing, Yong Zhou, Jun Yu, Yingyan Yu, Yongzhan Nie, Wen Luo, Chao Yang, Teng Xiong, William K. K. Wu, Zhongwu Li, Yang Bing, Shuye Lin, Yaping Zhang, Yingqi Hu, Lin Li, Lijuan Han, Chen Yang, Shaogang Huang, Suiping Huang, Rui Zhou, Jing Li, Kaichun Wu, Daiming Fan, Guangbo Tang, Jianhua Dou, Zhenggang Zhu, Jiafu Ji, Xiaodong Fang, Youyong Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/e5a9683dd37c418093b34ec48738cee1
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spelling oai:doaj.org-article:e5a9683dd37c418093b34ec48738cee12021-12-02T15:35:51ZWhole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer10.1038/s41467-019-09644-62041-1723https://doaj.org/article/e5a9683dd37c418093b34ec48738cee12019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09644-6https://doaj.org/toc/2041-1723Structural variations in gastric cancer impact progression. Here, the authors perform whole-genome sequencing on 168 gastric cancer patients and identified tandem-duplications of super-enhancer ZFP36L2 in 10% of gastric cancer, and mutational signatures in tumors with cadherin 1 mutations that associated with poor prognoses.Rui XingYong ZhouJun YuYingyan YuYongzhan NieWen LuoChao YangTeng XiongWilliam K. K. WuZhongwu LiYang BingShuye LinYaping ZhangYingqi HuLin LiLijuan HanChen YangShaogang HuangSuiping HuangRui ZhouJing LiKaichun WuDaiming FanGuangbo TangJianhua DouZhenggang ZhuJiafu JiXiaodong FangYouyong LuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rui Xing
Yong Zhou
Jun Yu
Yingyan Yu
Yongzhan Nie
Wen Luo
Chao Yang
Teng Xiong
William K. K. Wu
Zhongwu Li
Yang Bing
Shuye Lin
Yaping Zhang
Yingqi Hu
Lin Li
Lijuan Han
Chen Yang
Shaogang Huang
Suiping Huang
Rui Zhou
Jing Li
Kaichun Wu
Daiming Fan
Guangbo Tang
Jianhua Dou
Zhenggang Zhu
Jiafu Ji
Xiaodong Fang
Youyong Lu
Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer
description Structural variations in gastric cancer impact progression. Here, the authors perform whole-genome sequencing on 168 gastric cancer patients and identified tandem-duplications of super-enhancer ZFP36L2 in 10% of gastric cancer, and mutational signatures in tumors with cadherin 1 mutations that associated with poor prognoses.
format article
author Rui Xing
Yong Zhou
Jun Yu
Yingyan Yu
Yongzhan Nie
Wen Luo
Chao Yang
Teng Xiong
William K. K. Wu
Zhongwu Li
Yang Bing
Shuye Lin
Yaping Zhang
Yingqi Hu
Lin Li
Lijuan Han
Chen Yang
Shaogang Huang
Suiping Huang
Rui Zhou
Jing Li
Kaichun Wu
Daiming Fan
Guangbo Tang
Jianhua Dou
Zhenggang Zhu
Jiafu Ji
Xiaodong Fang
Youyong Lu
author_facet Rui Xing
Yong Zhou
Jun Yu
Yingyan Yu
Yongzhan Nie
Wen Luo
Chao Yang
Teng Xiong
William K. K. Wu
Zhongwu Li
Yang Bing
Shuye Lin
Yaping Zhang
Yingqi Hu
Lin Li
Lijuan Han
Chen Yang
Shaogang Huang
Suiping Huang
Rui Zhou
Jing Li
Kaichun Wu
Daiming Fan
Guangbo Tang
Jianhua Dou
Zhenggang Zhu
Jiafu Ji
Xiaodong Fang
Youyong Lu
author_sort Rui Xing
title Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer
title_short Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer
title_full Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer
title_fullStr Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer
title_full_unstemmed Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer
title_sort whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/e5a9683dd37c418093b34ec48738cee1
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