Structural basis for Ca2+-dependent activation of a plant metacaspase

Plant metacaspases mediate immune response following activation by Ca2+. Here, via crystallography and functional analyses, the authors show that a linker domain in Arabidopsis Metacaspase 4 blocks substrate access to the active site but is cleaved multiple times in the presence of Ca2+ to allow enz...

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Autores principales:	Ping Zhu, Xiao-Hong Yu, Cheng Wang, Qingfang Zhang, Wu Liu, Sean McSweeney, John Shanklin, Eric Lam, Qun Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e5aae62ead4748e8a9ae606526a29d0f
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spelling	oai:doaj.org-article:e5aae62ead4748e8a9ae606526a29d0f2021-12-02T17:33:15ZStructural basis for Ca2+-dependent activation of a plant metacaspase10.1038/s41467-020-15830-82041-1723https://doaj.org/article/e5aae62ead4748e8a9ae606526a29d0f2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15830-8https://doaj.org/toc/2041-1723Plant metacaspases mediate immune response following activation by Ca2+. Here, via crystallography and functional analyses, the authors show that a linker domain in Arabidopsis Metacaspase 4 blocks substrate access to the active site but is cleaved multiple times in the presence of Ca2+ to allow enzyme activation.Ping ZhuXiao-Hong YuCheng WangQingfang ZhangWu LiuSean McSweeneyJohn ShanklinEric LamQun LiuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ping Zhu Xiao-Hong Yu Cheng Wang Qingfang Zhang Wu Liu Sean McSweeney John Shanklin Eric Lam Qun Liu Structural basis for Ca2+-dependent activation of a plant metacaspase
description	Plant metacaspases mediate immune response following activation by Ca2+. Here, via crystallography and functional analyses, the authors show that a linker domain in Arabidopsis Metacaspase 4 blocks substrate access to the active site but is cleaved multiple times in the presence of Ca2+ to allow enzyme activation.
format	article
author	Ping Zhu Xiao-Hong Yu Cheng Wang Qingfang Zhang Wu Liu Sean McSweeney John Shanklin Eric Lam Qun Liu
author_facet	Ping Zhu Xiao-Hong Yu Cheng Wang Qingfang Zhang Wu Liu Sean McSweeney John Shanklin Eric Lam Qun Liu
author_sort	Ping Zhu
title	Structural basis for Ca2+-dependent activation of a plant metacaspase
title_short	Structural basis for Ca2+-dependent activation of a plant metacaspase
title_full	Structural basis for Ca2+-dependent activation of a plant metacaspase
title_fullStr	Structural basis for Ca2+-dependent activation of a plant metacaspase
title_full_unstemmed	Structural basis for Ca2+-dependent activation of a plant metacaspase
title_sort	structural basis for ca2+-dependent activation of a plant metacaspase
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e5aae62ead4748e8a9ae606526a29d0f
work_keys_str_mv	AT pingzhu structuralbasisforca2dependentactivationofaplantmetacaspase AT xiaohongyu structuralbasisforca2dependentactivationofaplantmetacaspase AT chengwang structuralbasisforca2dependentactivationofaplantmetacaspase AT qingfangzhang structuralbasisforca2dependentactivationofaplantmetacaspase AT wuliu structuralbasisforca2dependentactivationofaplantmetacaspase AT seanmcsweeney structuralbasisforca2dependentactivationofaplantmetacaspase AT johnshanklin structuralbasisforca2dependentactivationofaplantmetacaspase AT ericlam structuralbasisforca2dependentactivationofaplantmetacaspase AT qunliu structuralbasisforca2dependentactivationofaplantmetacaspase
_version_	1718380033616117760

Structural basis for Ca2+-dependent activation of a plant metacaspase

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