Association between the C-reactive protein/albumin ratio and prognosis in patients with oral squamous cell carcinoma

Abstract The systemic inflammatory response is known to be associated with poor outcomes in patients with various types of cancer. The C-reactive protein (CRP)/albumin (Alb) ratio (CAR) has been reported as a novel inflammation-based prognostic marker. We have evaluated the prognostic value of infla...

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Autores principales:	Kenji Yamagata, Satoshi Fukuzawa, Naomi Ishibashi-Kanno, Fumihiko Uchida, Hiroki Bukawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e5aec16d05f64c93898a8e2b6c38debf
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spelling	oai:doaj.org-article:e5aec16d05f64c93898a8e2b6c38debf2021-12-02T13:34:51ZAssociation between the C-reactive protein/albumin ratio and prognosis in patients with oral squamous cell carcinoma10.1038/s41598-021-83362-22045-2322https://doaj.org/article/e5aec16d05f64c93898a8e2b6c38debf2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83362-2https://doaj.org/toc/2045-2322Abstract The systemic inflammatory response is known to be associated with poor outcomes in patients with various types of cancer. The C-reactive protein (CRP)/albumin (Alb) ratio (CAR) has been reported as a novel inflammation-based prognostic marker. We have evaluated the prognostic value of inflammatory markers for patients with oral squamous cell carcinoma (OSCC). The study population included 205 patients treated with OSCC between 2013 and 2018. The primary predictor variable was the inflammatory markers. The primary outcome variable was overall survival (OS). Univariate and multivariate analyses were performed using a Cox proportional hazards model to identify independent prognostic factors. The CAR had the highest area under the curve (AUC) values compared with other markers in the receiver operating characteristic (ROC) curve analysis. The cutoff value for CAR was 0.032 (AUC 0.693, P < 0.001). There was a significant difference in OS when patients were stratified according to CAR, with 79.1% for CAR < 0.032 and 35% for CAR ≥ 0.032 (P < 0.001). Cox multivariate analysis identified independent predictive factors for OS: age (hazard ratio [HR] 2.155, 95% confidence interval [CI] 1.262–3.682; P = 0.005), stage (HR 3.031, 95% CI 1.576–5.827; P = 0.001), and CAR (HR 2.859, 95% CI 1.667–4.904; P < 0.001). CAR (≥ 0.032 vs. < 0.032) is a good prognostic marker in patients with OSCC in terms of age and stage.Kenji YamagataSatoshi FukuzawaNaomi Ishibashi-KannoFumihiko UchidaHiroki BukawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kenji Yamagata Satoshi Fukuzawa Naomi Ishibashi-Kanno Fumihiko Uchida Hiroki Bukawa Association between the C-reactive protein/albumin ratio and prognosis in patients with oral squamous cell carcinoma
description	Abstract The systemic inflammatory response is known to be associated with poor outcomes in patients with various types of cancer. The C-reactive protein (CRP)/albumin (Alb) ratio (CAR) has been reported as a novel inflammation-based prognostic marker. We have evaluated the prognostic value of inflammatory markers for patients with oral squamous cell carcinoma (OSCC). The study population included 205 patients treated with OSCC between 2013 and 2018. The primary predictor variable was the inflammatory markers. The primary outcome variable was overall survival (OS). Univariate and multivariate analyses were performed using a Cox proportional hazards model to identify independent prognostic factors. The CAR had the highest area under the curve (AUC) values compared with other markers in the receiver operating characteristic (ROC) curve analysis. The cutoff value for CAR was 0.032 (AUC 0.693, P < 0.001). There was a significant difference in OS when patients were stratified according to CAR, with 79.1% for CAR < 0.032 and 35% for CAR ≥ 0.032 (P < 0.001). Cox multivariate analysis identified independent predictive factors for OS: age (hazard ratio [HR] 2.155, 95% confidence interval [CI] 1.262–3.682; P = 0.005), stage (HR 3.031, 95% CI 1.576–5.827; P = 0.001), and CAR (HR 2.859, 95% CI 1.667–4.904; P < 0.001). CAR (≥ 0.032 vs. < 0.032) is a good prognostic marker in patients with OSCC in terms of age and stage.
format	article
author	Kenji Yamagata Satoshi Fukuzawa Naomi Ishibashi-Kanno Fumihiko Uchida Hiroki Bukawa
author_facet	Kenji Yamagata Satoshi Fukuzawa Naomi Ishibashi-Kanno Fumihiko Uchida Hiroki Bukawa
author_sort	Kenji Yamagata
title	Association between the C-reactive protein/albumin ratio and prognosis in patients with oral squamous cell carcinoma
title_short	Association between the C-reactive protein/albumin ratio and prognosis in patients with oral squamous cell carcinoma
title_full	Association between the C-reactive protein/albumin ratio and prognosis in patients with oral squamous cell carcinoma
title_fullStr	Association between the C-reactive protein/albumin ratio and prognosis in patients with oral squamous cell carcinoma
title_full_unstemmed	Association between the C-reactive protein/albumin ratio and prognosis in patients with oral squamous cell carcinoma
title_sort	association between the c-reactive protein/albumin ratio and prognosis in patients with oral squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e5aec16d05f64c93898a8e2b6c38debf
work_keys_str_mv	AT kenjiyamagata associationbetweenthecreactiveproteinalbuminratioandprognosisinpatientswithoralsquamouscellcarcinoma AT satoshifukuzawa associationbetweenthecreactiveproteinalbuminratioandprognosisinpatientswithoralsquamouscellcarcinoma AT naomiishibashikanno associationbetweenthecreactiveproteinalbuminratioandprognosisinpatientswithoralsquamouscellcarcinoma AT fumihikouchida associationbetweenthecreactiveproteinalbuminratioandprognosisinpatientswithoralsquamouscellcarcinoma AT hirokibukawa associationbetweenthecreactiveproteinalbuminratioandprognosisinpatientswithoralsquamouscellcarcinoma
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Association between the C-reactive protein/albumin ratio and prognosis in patients with oral squamous cell carcinoma

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