Effects of Chronic Social Defeat Stress on Behavior and Dopamine Receptors in Adolescent Mice With 6-Hydroxydopamine Lesions of the Medial Prefrontal Cortex

Background: Social stress factors in schizophrenia have long-term effects, but will only induce symptoms in a portion of individuals, even if exposed to identical stress.Methods: In the current experiment, we examined mice with 6-hydroxydopamine (6-OHDA)-induced medial prefrontal cortical (mPFC) inj...

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Autores principales:	Tong Zhao, XiaoLei Gao, Guang-Biao Huang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	schizophrenia social defeat stress stress-susceptible behavior dopamine receptor prefrontal cortex Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/e5af70e8b2f14d9b8ed88ecc3675f364
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spelling	oai:doaj.org-article:e5af70e8b2f14d9b8ed88ecc3675f3642021-12-01T13:58:54ZEffects of Chronic Social Defeat Stress on Behavior and Dopamine Receptors in Adolescent Mice With 6-Hydroxydopamine Lesions of the Medial Prefrontal Cortex1662-515310.3389/fnbeh.2021.731373https://doaj.org/article/e5af70e8b2f14d9b8ed88ecc3675f3642021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnbeh.2021.731373/fullhttps://doaj.org/toc/1662-5153Background: Social stress factors in schizophrenia have long-term effects, but will only induce symptoms in a portion of individuals, even if exposed to identical stress.Methods: In the current experiment, we examined mice with 6-hydroxydopamine (6-OHDA)-induced medial prefrontal cortical (mPFC) injury to select for members of a “stress-susceptible group,” and observed the changes in their behavior and the expression of D1 and D2 dopamine receptors in the amygdala and hippocampus.Results: We observed that after chronic social defeat stress, 72.6% of the 6-OHDA lesioned mice exhibited stress response to aggressors, compared to 52.3% of the blank control group. Both the 6-OHDA lesion + social defeat and social defeat groups exhibited anxiety and depression-like behavior. However, social cognitive impairment in the mice from the 6-OHDA lesion + social defeat group was more significant and the D1 expression levels in the amygdala were significantly decreased.Conclusion: These results suggest that the reason that adolescent mice with cortical injury were highly sensitive to defeat stress and had more prominent social cognitive impairment may be the decreased selectivity of D1 in the amygdala.Tong ZhaoXiaoLei GaoGuang-Biao HuangFrontiers Media S.A.articleschizophreniasocial defeat stressstress-susceptiblebehaviordopamine receptorprefrontal cortexNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Behavioral Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia social defeat stress stress-susceptible behavior dopamine receptor prefrontal cortex Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	schizophrenia social defeat stress stress-susceptible behavior dopamine receptor prefrontal cortex Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Tong Zhao XiaoLei Gao Guang-Biao Huang Effects of Chronic Social Defeat Stress on Behavior and Dopamine Receptors in Adolescent Mice With 6-Hydroxydopamine Lesions of the Medial Prefrontal Cortex
description	Background: Social stress factors in schizophrenia have long-term effects, but will only induce symptoms in a portion of individuals, even if exposed to identical stress.Methods: In the current experiment, we examined mice with 6-hydroxydopamine (6-OHDA)-induced medial prefrontal cortical (mPFC) injury to select for members of a “stress-susceptible group,” and observed the changes in their behavior and the expression of D1 and D2 dopamine receptors in the amygdala and hippocampus.Results: We observed that after chronic social defeat stress, 72.6% of the 6-OHDA lesioned mice exhibited stress response to aggressors, compared to 52.3% of the blank control group. Both the 6-OHDA lesion + social defeat and social defeat groups exhibited anxiety and depression-like behavior. However, social cognitive impairment in the mice from the 6-OHDA lesion + social defeat group was more significant and the D1 expression levels in the amygdala were significantly decreased.Conclusion: These results suggest that the reason that adolescent mice with cortical injury were highly sensitive to defeat stress and had more prominent social cognitive impairment may be the decreased selectivity of D1 in the amygdala.
format	article
author	Tong Zhao XiaoLei Gao Guang-Biao Huang
author_facet	Tong Zhao XiaoLei Gao Guang-Biao Huang
author_sort	Tong Zhao
title	Effects of Chronic Social Defeat Stress on Behavior and Dopamine Receptors in Adolescent Mice With 6-Hydroxydopamine Lesions of the Medial Prefrontal Cortex
title_short	Effects of Chronic Social Defeat Stress on Behavior and Dopamine Receptors in Adolescent Mice With 6-Hydroxydopamine Lesions of the Medial Prefrontal Cortex
title_full	Effects of Chronic Social Defeat Stress on Behavior and Dopamine Receptors in Adolescent Mice With 6-Hydroxydopamine Lesions of the Medial Prefrontal Cortex
title_fullStr	Effects of Chronic Social Defeat Stress on Behavior and Dopamine Receptors in Adolescent Mice With 6-Hydroxydopamine Lesions of the Medial Prefrontal Cortex
title_full_unstemmed	Effects of Chronic Social Defeat Stress on Behavior and Dopamine Receptors in Adolescent Mice With 6-Hydroxydopamine Lesions of the Medial Prefrontal Cortex
title_sort	effects of chronic social defeat stress on behavior and dopamine receptors in adolescent mice with 6-hydroxydopamine lesions of the medial prefrontal cortex
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e5af70e8b2f14d9b8ed88ecc3675f364
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Effects of Chronic Social Defeat Stress on Behavior and Dopamine Receptors in Adolescent Mice With 6-Hydroxydopamine Lesions of the Medial Prefrontal Cortex

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