Gut Microbiota as Early Predictor of Infectious Complications before Cardiac Surgery: A Prospective Pilot Study

Cardiac surgery remains a field of medicine with a high percentage of postoperative complications, including infectious ones. Modern data indicate a close relationship of infectious disorders with pathological changes in the composition of the gut microbiome; however, the extent of such changes in c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ekaterina Chernevskaya, Evgenii Zuev, Vera Odintsova, Anastasiia Meglei, Natalia Beloborodova
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cardiovascular diseases 16S RNA sequencing microbiome biomarkers critically ill Medicine R
Acceso en línea:	https://doaj.org/article/e5b19b7432de49fe9a3adb38671f6353
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e5b19b7432de49fe9a3adb38671f6353
record_format	dspace
spelling	oai:doaj.org-article:e5b19b7432de49fe9a3adb38671f63532021-11-25T18:07:18ZGut Microbiota as Early Predictor of Infectious Complications before Cardiac Surgery: A Prospective Pilot Study10.3390/jpm111111132075-4426https://doaj.org/article/e5b19b7432de49fe9a3adb38671f63532021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1113https://doaj.org/toc/2075-4426Cardiac surgery remains a field of medicine with a high percentage of postoperative complications, including infectious ones. Modern data indicate a close relationship of infectious disorders with pathological changes in the composition of the gut microbiome; however, the extent of such changes in cardiac surgery patients is not fully clarified. In this prospective, observational, single center, pilot study, 72 patients were included, 12 among them with the infectious complications. We analyzed the features of the fecal microbiota before and in the early postoperative period, as one of the markers for predicting the occurrence of bacterial infection. We also discovered the significant change in microbial composition in the group of patients with infectious complications compared to the non-infectious group before and after cardiac surgery, despite the intra-individual variation in composition of gut microbiome. Our study demonstrated that the group of patients that had a bacterial infection in the early postoperative period already had an altered microbial composition even before the surgery. Further studies will evaluate the clinical significance of the identified proportions of individual taxa of the intestinal microbiota and consider the microbiota as a novel target for reducing the risk of infectious complications.Ekaterina ChernevskayaEvgenii ZuevVera OdintsovaAnastasiia MegleiNatalia BeloborodovaMDPI AGarticlecardiovascular diseases16S RNA sequencingmicrobiomebiomarkerscritically illMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1113, p 1113 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular diseases 16S RNA sequencing microbiome biomarkers critically ill Medicine R
spellingShingle	cardiovascular diseases 16S RNA sequencing microbiome biomarkers critically ill Medicine R Ekaterina Chernevskaya Evgenii Zuev Vera Odintsova Anastasiia Meglei Natalia Beloborodova Gut Microbiota as Early Predictor of Infectious Complications before Cardiac Surgery: A Prospective Pilot Study
description	Cardiac surgery remains a field of medicine with a high percentage of postoperative complications, including infectious ones. Modern data indicate a close relationship of infectious disorders with pathological changes in the composition of the gut microbiome; however, the extent of such changes in cardiac surgery patients is not fully clarified. In this prospective, observational, single center, pilot study, 72 patients were included, 12 among them with the infectious complications. We analyzed the features of the fecal microbiota before and in the early postoperative period, as one of the markers for predicting the occurrence of bacterial infection. We also discovered the significant change in microbial composition in the group of patients with infectious complications compared to the non-infectious group before and after cardiac surgery, despite the intra-individual variation in composition of gut microbiome. Our study demonstrated that the group of patients that had a bacterial infection in the early postoperative period already had an altered microbial composition even before the surgery. Further studies will evaluate the clinical significance of the identified proportions of individual taxa of the intestinal microbiota and consider the microbiota as a novel target for reducing the risk of infectious complications.
format	article
author	Ekaterina Chernevskaya Evgenii Zuev Vera Odintsova Anastasiia Meglei Natalia Beloborodova
author_facet	Ekaterina Chernevskaya Evgenii Zuev Vera Odintsova Anastasiia Meglei Natalia Beloborodova
author_sort	Ekaterina Chernevskaya
title	Gut Microbiota as Early Predictor of Infectious Complications before Cardiac Surgery: A Prospective Pilot Study
title_short	Gut Microbiota as Early Predictor of Infectious Complications before Cardiac Surgery: A Prospective Pilot Study
title_full	Gut Microbiota as Early Predictor of Infectious Complications before Cardiac Surgery: A Prospective Pilot Study
title_fullStr	Gut Microbiota as Early Predictor of Infectious Complications before Cardiac Surgery: A Prospective Pilot Study
title_full_unstemmed	Gut Microbiota as Early Predictor of Infectious Complications before Cardiac Surgery: A Prospective Pilot Study
title_sort	gut microbiota as early predictor of infectious complications before cardiac surgery: a prospective pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e5b19b7432de49fe9a3adb38671f6353
work_keys_str_mv	AT ekaterinachernevskaya gutmicrobiotaasearlypredictorofinfectiouscomplicationsbeforecardiacsurgeryaprospectivepilotstudy AT evgeniizuev gutmicrobiotaasearlypredictorofinfectiouscomplicationsbeforecardiacsurgeryaprospectivepilotstudy AT veraodintsova gutmicrobiotaasearlypredictorofinfectiouscomplicationsbeforecardiacsurgeryaprospectivepilotstudy AT anastasiiameglei gutmicrobiotaasearlypredictorofinfectiouscomplicationsbeforecardiacsurgeryaprospectivepilotstudy AT nataliabeloborodova gutmicrobiotaasearlypredictorofinfectiouscomplicationsbeforecardiacsurgeryaprospectivepilotstudy
_version_	1718411653214633984

Gut Microbiota as Early Predictor of Infectious Complications before Cardiac Surgery: A Prospective Pilot Study

Ejemplares similares