Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode

A sensitive electrochemical sensor was developed using reduced graphene oxide RGO-Cu2O/Fe2O3 nanocomposite for 6-mercaptopurine detection based on a facile fabrication method. The surface morphology and structural composition of this nanocomposite was evaluated by X-ray diffraction (XRD), field emi...

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Autores principales:	Fatemeh Irannezhad, Jamileh Seyed-Yazdi, Seyedeh Hoda Hekmatara
Formato:	article
Lenguaje:	EN
Publicado:	International Association of Physical Chemists (IAPC) 2021
Materias:	electrochemical sensor reduced graphene oxide copper(I) oxide iron(III) oxide Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e5b39f342e684ff4b4bc1e7f9ec59d65
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spelling	oai:doaj.org-article:e5b39f342e684ff4b4bc1e7f9ec59d652021-11-15T10:03:46ZElectrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode10.5599/jese.11011847-9286https://doaj.org/article/e5b39f342e684ff4b4bc1e7f9ec59d652021-11-01T00:00:00Zhttps://pub.iapchem.org/ojs/index.php/JESE/article/view/1101https://doaj.org/toc/1847-9286 A sensitive electrochemical sensor was developed using reduced graphene oxide RGO-Cu2O/Fe2O3 nanocomposite for 6-mercaptopurine detection based on a facile fabrication method. The surface morphology and structural composition of this nanocomposite was evaluated by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and Fourier transform infrared (FT-IR) spectroscopy. The screen-printed graphite electrode (SPGE) modified with RGO-Cu2O/Fe2O3 nanocomposite (RGO-Cu2O/Fe2O3/SPGE) indicated excellent electrochemical properties to detect 6-mercaptopurine. The linear dynamic range was estimated between 0.05 and 400.0 μM for 6-mercaptopurine detection, with a limit of detection of 0.03 μM. Also, RGO-Cu2O/Fe2O3/SPGE sensor showed good activity for simultaneous detection of 6-mercaptopurine and 6-thioguanine. In the coexistence system of 6-mercaptopurine and 6-thioguanine, two clear and well-isolated voltammetric peaks were obtained by differential pulse voltammetry (DPV). Additionally, the proposed sensor was examined for applicability by determining 6-mercaptopurine and 6-thioguanine in real samples, and the recovery in the range of 97.5-103.0 % was obtained. Fatemeh IrannezhadJamileh Seyed-YazdiSeyedeh Hoda HekmataraInternational Association of Physical Chemists (IAPC)articleelectrochemical sensorreduced graphene oxidecopper(I) oxideiron(III) oxideChemistryQD1-999ENJournal of Electrochemical Science and Engineering, Vol 11, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	electrochemical sensor reduced graphene oxide copper(I) oxide iron(III) oxide Chemistry QD1-999
spellingShingle	electrochemical sensor reduced graphene oxide copper(I) oxide iron(III) oxide Chemistry QD1-999 Fatemeh Irannezhad Jamileh Seyed-Yazdi Seyedeh Hoda Hekmatara Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode
description	A sensitive electrochemical sensor was developed using reduced graphene oxide RGO-Cu2O/Fe2O3 nanocomposite for 6-mercaptopurine detection based on a facile fabrication method. The surface morphology and structural composition of this nanocomposite was evaluated by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and Fourier transform infrared (FT-IR) spectroscopy. The screen-printed graphite electrode (SPGE) modified with RGO-Cu2O/Fe2O3 nanocomposite (RGO-Cu2O/Fe2O3/SPGE) indicated excellent electrochemical properties to detect 6-mercaptopurine. The linear dynamic range was estimated between 0.05 and 400.0 μM for 6-mercaptopurine detection, with a limit of detection of 0.03 μM. Also, RGO-Cu2O/Fe2O3/SPGE sensor showed good activity for simultaneous detection of 6-mercaptopurine and 6-thioguanine. In the coexistence system of 6-mercaptopurine and 6-thioguanine, two clear and well-isolated voltammetric peaks were obtained by differential pulse voltammetry (DPV). Additionally, the proposed sensor was examined for applicability by determining 6-mercaptopurine and 6-thioguanine in real samples, and the recovery in the range of 97.5-103.0 % was obtained.
format	article
author	Fatemeh Irannezhad Jamileh Seyed-Yazdi Seyedeh Hoda Hekmatara
author_facet	Fatemeh Irannezhad Jamileh Seyed-Yazdi Seyedeh Hoda Hekmatara
author_sort	Fatemeh Irannezhad
title	Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode
title_short	Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode
title_full	Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode
title_fullStr	Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode
title_full_unstemmed	Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode
title_sort	electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using rgo-cu2o/fe2o3 modified screen-printed graphite electrode
publisher	International Association of Physical Chemists (IAPC)
publishDate	2021
url	https://doaj.org/article/e5b39f342e684ff4b4bc1e7f9ec59d65
work_keys_str_mv	AT fatemehirannezhad electrochemicalsensingplatformforsimultaneousdetectionof6mercaptopurineand6thioguanineusingrgocu2ofe2o3modifiedscreenprintedgraphiteelectrode AT jamilehseyedyazdi electrochemicalsensingplatformforsimultaneousdetectionof6mercaptopurineand6thioguanineusingrgocu2ofe2o3modifiedscreenprintedgraphiteelectrode AT seyedehhodahekmatara electrochemicalsensingplatformforsimultaneousdetectionof6mercaptopurineand6thioguanineusingrgocu2ofe2o3modifiedscreenprintedgraphiteelectrode
_version_	1718428467503038464

Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode

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