Strong association of glaucoma with atherosclerosis

Abstract Carbonic anhydrases (CAs) catalyze the synthesis of HCO3 - from H2O and CO2. The dysfunction of CAs leads to aqueous humor secretion and high intraocular pressure to cause glaucoma pathogenesis. Methazolamide (MTZ), a CA inhibitor, can effectively treat glaucoma by reducing aqueous humor se...

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Autores principales:	Xianqin Song, Peng Li, Yunfeng Li, Xinfeng Yan, Lin Yuan, Cong Zhao, Yi An, Xiaotian Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e5b5aa315eef4da0a9d4c9a4db818df3
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spelling	oai:doaj.org-article:e5b5aa315eef4da0a9d4c9a4db818df32021-12-02T16:45:14ZStrong association of glaucoma with atherosclerosis10.1038/s41598-021-88322-42045-2322https://doaj.org/article/e5b5aa315eef4da0a9d4c9a4db818df32021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88322-4https://doaj.org/toc/2045-2322Abstract Carbonic anhydrases (CAs) catalyze the synthesis of HCO3 - from H2O and CO2. The dysfunction of CAs leads to aqueous humor secretion and high intraocular pressure to cause glaucoma pathogenesis. Methazolamide (MTZ), a CA inhibitor, can effectively treat glaucoma by reducing aqueous humor secretion. We previously reported that carbonic anhydrase I (CA1), a CA family member, was highly expressed in atherosclerotic tissues of the aorta and stimulated atherosclerosis (AS) by promoting calcification. MTZ showed therapeutic and preventive effects on AS in a mouse model. The above findings suggest a relationship between AS and glaucoma. This study explored the possible association between AS prevalence and glaucoma prevalence and the therapeutic effect of MTZ on AS by analyzing medical records. Among 10,751 patients with a primary diagnosis of glaucoma, 699 (6.5%) were also diagnosed with AS. However, the incidences of AS in patients with keratitis and scleritis, which are also ophthalmic diseases, were 2.5% (206/8383 patients) and 3.5% (46/1308 patients), respectively. In the population without ophthalmic records, the AS prevalence was only 1.9% (99,416/5,168,481 patients) (all p values between each group were below 0.001). Among 152,425 patients with a primary diagnosis of AS, 1245 (0.82%) were also diagnosed with glaucoma. Among 199,782 patients with a primary diagnosis of hypertension (excluding AS), 1149 (0.57%) were diagnosed with glaucoma, and among 5,313,433 patients without AS or hypertension, 9513 (0.18%) were diagnosed with glaucoma (all p values between each group were below 0.001). Additionally, among 14 patients who suffered from both AS and glaucoma and were treated with MTZ to cure their glaucoma, 9 of them showed reduced low-density lipoprotein (LDL) levels, the main index of AS, within 3 months after medication use (2.81 ± 0.61 mmol/L vs. 2.38 ± 0.58 mmol/L, p = 0.039). The above findings demonstrated a strong relation between AS and glaucoma and suggested that AS patients with glaucoma were more likely to suffer from angle-closure glaucoma.Xianqin SongPeng LiYunfeng LiXinfeng YanLin YuanCong ZhaoYi AnXiaotian ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xianqin Song Peng Li Yunfeng Li Xinfeng Yan Lin Yuan Cong Zhao Yi An Xiaotian Chang Strong association of glaucoma with atherosclerosis
description	Abstract Carbonic anhydrases (CAs) catalyze the synthesis of HCO3 - from H2O and CO2. The dysfunction of CAs leads to aqueous humor secretion and high intraocular pressure to cause glaucoma pathogenesis. Methazolamide (MTZ), a CA inhibitor, can effectively treat glaucoma by reducing aqueous humor secretion. We previously reported that carbonic anhydrase I (CA1), a CA family member, was highly expressed in atherosclerotic tissues of the aorta and stimulated atherosclerosis (AS) by promoting calcification. MTZ showed therapeutic and preventive effects on AS in a mouse model. The above findings suggest a relationship between AS and glaucoma. This study explored the possible association between AS prevalence and glaucoma prevalence and the therapeutic effect of MTZ on AS by analyzing medical records. Among 10,751 patients with a primary diagnosis of glaucoma, 699 (6.5%) were also diagnosed with AS. However, the incidences of AS in patients with keratitis and scleritis, which are also ophthalmic diseases, were 2.5% (206/8383 patients) and 3.5% (46/1308 patients), respectively. In the population without ophthalmic records, the AS prevalence was only 1.9% (99,416/5,168,481 patients) (all p values between each group were below 0.001). Among 152,425 patients with a primary diagnosis of AS, 1245 (0.82%) were also diagnosed with glaucoma. Among 199,782 patients with a primary diagnosis of hypertension (excluding AS), 1149 (0.57%) were diagnosed with glaucoma, and among 5,313,433 patients without AS or hypertension, 9513 (0.18%) were diagnosed with glaucoma (all p values between each group were below 0.001). Additionally, among 14 patients who suffered from both AS and glaucoma and were treated with MTZ to cure their glaucoma, 9 of them showed reduced low-density lipoprotein (LDL) levels, the main index of AS, within 3 months after medication use (2.81 ± 0.61 mmol/L vs. 2.38 ± 0.58 mmol/L, p = 0.039). The above findings demonstrated a strong relation between AS and glaucoma and suggested that AS patients with glaucoma were more likely to suffer from angle-closure glaucoma.
format	article
author	Xianqin Song Peng Li Yunfeng Li Xinfeng Yan Lin Yuan Cong Zhao Yi An Xiaotian Chang
author_facet	Xianqin Song Peng Li Yunfeng Li Xinfeng Yan Lin Yuan Cong Zhao Yi An Xiaotian Chang
author_sort	Xianqin Song
title	Strong association of glaucoma with atherosclerosis
title_short	Strong association of glaucoma with atherosclerosis
title_full	Strong association of glaucoma with atherosclerosis
title_fullStr	Strong association of glaucoma with atherosclerosis
title_full_unstemmed	Strong association of glaucoma with atherosclerosis
title_sort	strong association of glaucoma with atherosclerosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e5b5aa315eef4da0a9d4c9a4db818df3
work_keys_str_mv	AT xianqinsong strongassociationofglaucomawithatherosclerosis AT pengli strongassociationofglaucomawithatherosclerosis AT yunfengli strongassociationofglaucomawithatherosclerosis AT xinfengyan strongassociationofglaucomawithatherosclerosis AT linyuan strongassociationofglaucomawithatherosclerosis AT congzhao strongassociationofglaucomawithatherosclerosis AT yian strongassociationofglaucomawithatherosclerosis AT xiaotianchang strongassociationofglaucomawithatherosclerosis
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Strong association of glaucoma with atherosclerosis

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