Immune gene network of neurological diseases: Multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD)

Neurological diseases, such as MS, AD, PD and HD, are a major health concern of the elderly population, but still therapeutic options are limited. Recent advances in genomic sequencing and bioinformatics, present an opportunity to understand mechanisms of these diseases for identification of therape...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Shradha Mukherjee
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Neurodegenerative diseases Multiple sclerosis Brain diseases Bioinformatics Gene networks WGCNA Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/e5b9f2021a5e49e482b5d6d1a02d079c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e5b9f2021a5e49e482b5d6d1a02d079c
record_format	dspace
spelling	oai:doaj.org-article:e5b9f2021a5e49e482b5d6d1a02d079c2021-12-04T04:35:27ZImmune gene network of neurological diseases: Multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD)2405-844010.1016/j.heliyon.2021.e08518https://doaj.org/article/e5b9f2021a5e49e482b5d6d1a02d079c2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021026219https://doaj.org/toc/2405-8440Neurological diseases, such as MS, AD, PD and HD, are a major health concern of the elderly population, but still therapeutic options are limited. Recent advances in genomic sequencing and bioinformatics, present an opportunity to understand mechanisms of these diseases for identification of therapeutic targets. Several studies have shown association of immune dysfunction with immune system mediated neurological disease, MS, as well as neurodegenerative diseases (AD, PD and HD). However, similarities and differences in role of the immune system, immune pathways and immune cell types in these diseases remains unknown. In this study, immune cell type signature genes in gene networks associated with neurological diseases, MS, AD, PD and HD was investigated using meta-analysis and bioinformatics methods. Application of Weighted Gene Co-expression Network Analysis (WGCNA) on publicly available gene expression datasets (microarray and RNA-seq) revealed a ModArray_04 module (microarray) or ModRNAseq_06 module (RNA-seq), significantly associated with MS, AD, PD and HD. Hypergeometric enrichment test revealed significant enrichment of immune cell type genes in these neurological disease modules. This study demonstrates that immune system mediated neurological disease, MS and neurodegenerative diseases (AD, PD and HD), share a common gene network characterized by immune cell type signature genes (microglia, monocytes and macrophages) and are probable targets for therapeutic intervention. In summary, this work shows a connection between MS, a disease where the role of the immune system and inflammation is established, and neurodegenerative diseases (AD, PD and HD) where the role of inflammation is still a hypothesis.Shradha MukherjeeElsevierarticleNeurodegenerative diseasesMultiple sclerosisBrain diseasesBioinformaticsGene networksWGCNAScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 12, Pp e08518- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurodegenerative diseases Multiple sclerosis Brain diseases Bioinformatics Gene networks WGCNA Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Neurodegenerative diseases Multiple sclerosis Brain diseases Bioinformatics Gene networks WGCNA Science (General) Q1-390 Social sciences (General) H1-99 Shradha Mukherjee Immune gene network of neurological diseases: Multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD)
description	Neurological diseases, such as MS, AD, PD and HD, are a major health concern of the elderly population, but still therapeutic options are limited. Recent advances in genomic sequencing and bioinformatics, present an opportunity to understand mechanisms of these diseases for identification of therapeutic targets. Several studies have shown association of immune dysfunction with immune system mediated neurological disease, MS, as well as neurodegenerative diseases (AD, PD and HD). However, similarities and differences in role of the immune system, immune pathways and immune cell types in these diseases remains unknown. In this study, immune cell type signature genes in gene networks associated with neurological diseases, MS, AD, PD and HD was investigated using meta-analysis and bioinformatics methods. Application of Weighted Gene Co-expression Network Analysis (WGCNA) on publicly available gene expression datasets (microarray and RNA-seq) revealed a ModArray_04 module (microarray) or ModRNAseq_06 module (RNA-seq), significantly associated with MS, AD, PD and HD. Hypergeometric enrichment test revealed significant enrichment of immune cell type genes in these neurological disease modules. This study demonstrates that immune system mediated neurological disease, MS and neurodegenerative diseases (AD, PD and HD), share a common gene network characterized by immune cell type signature genes (microglia, monocytes and macrophages) and are probable targets for therapeutic intervention. In summary, this work shows a connection between MS, a disease where the role of the immune system and inflammation is established, and neurodegenerative diseases (AD, PD and HD) where the role of inflammation is still a hypothesis.
format	article
author	Shradha Mukherjee
author_facet	Shradha Mukherjee
author_sort	Shradha Mukherjee
title	Immune gene network of neurological diseases: Multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD)
title_short	Immune gene network of neurological diseases: Multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD)
title_full	Immune gene network of neurological diseases: Multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD)
title_fullStr	Immune gene network of neurological diseases: Multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD)
title_full_unstemmed	Immune gene network of neurological diseases: Multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD)
title_sort	immune gene network of neurological diseases: multiple sclerosis (ms), alzheimer's disease (ad), parkinson's disease (pd) and huntington's disease (hd)
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/e5b9f2021a5e49e482b5d6d1a02d079c
work_keys_str_mv	AT shradhamukherjee immunegenenetworkofneurologicaldiseasesmultiplesclerosismsalzheimersdiseaseadparkinsonsdiseasepdandhuntingtonsdiseasehd
_version_	1718372944699195392

Immune gene network of neurological diseases: Multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD)

Ejemplares similares