Differential methylation is associated with non-syndromic cleft lip and palate and contributes to penetrance effects

Differential methylation is associated with non-syndromic cleft lip and palate and contributes to penetrance effects

Abstract Non-syndromic cleft lip and/or palate (NSCLP) is a common congenital malformation with a multifactorial model of inheritance. Although several at-risk alleles have been identified, they do not completely explain the high heritability. We postulate that epigenetic factors as DNA methylation...

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Autores principales: Lucas Alvizi, Xiayi Ke, Luciano Abreu Brito, Rimante Seselgyte, Gudrun E. Moore, Philip Stanier, Maria Rita Passos-Bueno
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/e5bb70625e764a11be2c07ab251f41fb
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