A multivalent T-antigen-based vaccine for Group A Streptococcus

Abstract Pili of Group A Streptococcus (GAS) are surface-exposed structures involved in adhesion and colonisation of the host during infection. The major protein component of the GAS pilus is the T-antigen, which multimerises to form the pilus shaft. There are currently no licenced vaccines against...

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Autores principales:	Jacelyn M. S. Loh, Tania Rivera-Hernandez, Reuben McGregor, Adrina Hema J. Khemlani, Mei Lin Tay, Amanda J. Cork, Jeremy M. Raynes, Nicole J. Moreland, Mark J. Walker, Thomas Proft
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e5c26595d82b49ec87d8e1591a0db673
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spelling	oai:doaj.org-article:e5c26595d82b49ec87d8e1591a0db6732021-12-02T16:23:14ZA multivalent T-antigen-based vaccine for Group A Streptococcus10.1038/s41598-021-83673-42045-2322https://doaj.org/article/e5c26595d82b49ec87d8e1591a0db6732021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83673-4https://doaj.org/toc/2045-2322Abstract Pili of Group A Streptococcus (GAS) are surface-exposed structures involved in adhesion and colonisation of the host during infection. The major protein component of the GAS pilus is the T-antigen, which multimerises to form the pilus shaft. There are currently no licenced vaccines against GAS infections and the T-antigen represents an attractive target for vaccination. We have generated a multivalent vaccine called TeeVax1, a recombinant protein that consists of a fusion of six T-antigen domains. Vaccination with TeeVax1 produces opsonophagocytic antibodies in rabbits and confers protective efficacy in mice against invasive disease. Two further recombinant proteins, TeeVax2 and TeeVax3 were constructed to cover 12 additional T-antigens. Combining TeeVax1–3 produced a robust antibody response in rabbits that was cross-reactive to a full panel of 21 T-antigens, expected to provide over 95% vaccine coverage. These results demonstrate the potential for a T-antigen-based vaccine to prevent GAS infections.Jacelyn M. S. LohTania Rivera-HernandezReuben McGregorAdrina Hema J. KhemlaniMei Lin TayAmanda J. CorkJeremy M. RaynesNicole J. MorelandMark J. WalkerThomas ProftNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jacelyn M. S. Loh Tania Rivera-Hernandez Reuben McGregor Adrina Hema J. Khemlani Mei Lin Tay Amanda J. Cork Jeremy M. Raynes Nicole J. Moreland Mark J. Walker Thomas Proft A multivalent T-antigen-based vaccine for Group A Streptococcus
description	Abstract Pili of Group A Streptococcus (GAS) are surface-exposed structures involved in adhesion and colonisation of the host during infection. The major protein component of the GAS pilus is the T-antigen, which multimerises to form the pilus shaft. There are currently no licenced vaccines against GAS infections and the T-antigen represents an attractive target for vaccination. We have generated a multivalent vaccine called TeeVax1, a recombinant protein that consists of a fusion of six T-antigen domains. Vaccination with TeeVax1 produces opsonophagocytic antibodies in rabbits and confers protective efficacy in mice against invasive disease. Two further recombinant proteins, TeeVax2 and TeeVax3 were constructed to cover 12 additional T-antigens. Combining TeeVax1–3 produced a robust antibody response in rabbits that was cross-reactive to a full panel of 21 T-antigens, expected to provide over 95% vaccine coverage. These results demonstrate the potential for a T-antigen-based vaccine to prevent GAS infections.
format	article
author	Jacelyn M. S. Loh Tania Rivera-Hernandez Reuben McGregor Adrina Hema J. Khemlani Mei Lin Tay Amanda J. Cork Jeremy M. Raynes Nicole J. Moreland Mark J. Walker Thomas Proft
author_facet	Jacelyn M. S. Loh Tania Rivera-Hernandez Reuben McGregor Adrina Hema J. Khemlani Mei Lin Tay Amanda J. Cork Jeremy M. Raynes Nicole J. Moreland Mark J. Walker Thomas Proft
author_sort	Jacelyn M. S. Loh
title	A multivalent T-antigen-based vaccine for Group A Streptococcus
title_short	A multivalent T-antigen-based vaccine for Group A Streptococcus
title_full	A multivalent T-antigen-based vaccine for Group A Streptococcus
title_fullStr	A multivalent T-antigen-based vaccine for Group A Streptococcus
title_full_unstemmed	A multivalent T-antigen-based vaccine for Group A Streptococcus
title_sort	multivalent t-antigen-based vaccine for group a streptococcus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e5c26595d82b49ec87d8e1591a0db673
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A multivalent T-antigen-based vaccine for Group A Streptococcus

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